Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. This project aims to develop a novel biosensor prototype based on CYBERNOSE® technology to rapidly identify volatile traces of illicit drugs and precursor chemicals in concealed environments. The CYBERNOSE® technology employs sensors using the highly sophisticated and sensitive olfactory receptors of microscopic nematode worms linked to an optoelectronic det ....Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. This project aims to develop a novel biosensor prototype based on CYBERNOSE® technology to rapidly identify volatile traces of illicit drugs and precursor chemicals in concealed environments. The CYBERNOSE® technology employs sensors using the highly sophisticated and sensitive olfactory receptors of microscopic nematode worms linked to an optoelectronic detector. The need for rapid, non-contact screening devices to detect and identify illicit drugs and precursors entering Australia has never been greater. Law enforcement agencies should directly benefit from the capability to more rapidly screen people and cargo, improving efficiency of illicit drug detection and protection of our borders.Read moreRead less
Applications of probiotics in yoghurt, soy yoghurt and Cheddar cheese. The main goal of this study is to develop probiotic yoghurt and Cheddar cheese using selected strains of probiotic bacteria and examine their survival and effects on proteolysis and sensory attributes of these products. Research aimed at enrichment of suitable probiotic adjunct starter in these products provides the potential to markedly improve both the health status and quality of products. Optimum conditions for survival o ....Applications of probiotics in yoghurt, soy yoghurt and Cheddar cheese. The main goal of this study is to develop probiotic yoghurt and Cheddar cheese using selected strains of probiotic bacteria and examine their survival and effects on proteolysis and sensory attributes of these products. Research aimed at enrichment of suitable probiotic adjunct starter in these products provides the potential to markedly improve both the health status and quality of products. Optimum conditions for survival of probiotic bacteria and processing conditions that guarantee high levels of probiotic bacteria for health benefits will be known. The results will provide critical information for improving survival of probiotic bacteria and quality of probiotic yoghurt, and Cheddar cheese.Read moreRead less
Stability of bioactive isoflavone aglycones and probiotic bacteria in soy based food during processing and storage. The aims of this study are to ascertain the optimum conditions for bioconversion of inactive isoflavone glucosides to bioactive isoflavone aglycones by bifidobacteria and assess the stability of bioactive aglycones during processing and storage. Studies have shown that dietary phytoestrogen an important role in prevention of cardiovascular disease, osteoporosis and breast and prost ....Stability of bioactive isoflavone aglycones and probiotic bacteria in soy based food during processing and storage. The aims of this study are to ascertain the optimum conditions for bioconversion of inactive isoflavone glucosides to bioactive isoflavone aglycones by bifidobacteria and assess the stability of bioactive aglycones during processing and storage. Studies have shown that dietary phytoestrogen an important role in prevention of cardiovascular disease, osteoporosis and breast and prostate cancer (Nagata et al., 1998). Optimum conditions for production of bioactive isoflavones and processing conditions that guarantee high levels of bioactive isoflavones for health benefits will be known. The results will provide critical information for creating market potential for a range of health based functional foods.Read moreRead less
Nanopore sensors for multiplexed, ultra-fast gene detection. The aim of this research is to develop the application of protein nanopores for multiplex identification of DNA samples for ultrafast gene detection. This is a type of barcoding of organism DNA that allows for rapid gene identification. This technology aims to address a significant need for rapid, on-the-spot identification of organisms. Applications include rapid identification of pathogenic bacteria in infections and identification o ....Nanopore sensors for multiplexed, ultra-fast gene detection. The aim of this research is to develop the application of protein nanopores for multiplex identification of DNA samples for ultrafast gene detection. This is a type of barcoding of organism DNA that allows for rapid gene identification. This technology aims to address a significant need for rapid, on-the-spot identification of organisms. Applications include rapid identification of pathogenic bacteria in infections and identification of organisms in environmental sampling. Current methods are relative slow, require DNA amplification and specialised laboratories.
This proposal aims to fine tune the properties of the large nanopore, polyC9, with respect to size and charge, as well as to identify and characterise novel large nanopores. Read moreRead less
Renewable energy from carbon dioxide: Process engineering to obtain bio-oil from algae. The Stern Report (2007)[1] has called for a CO2 REDUCTION BY MORE THAN 80% in 10-20 years to prevent profound changes in the climate over coming centuries. The proposed project will capture CO2 using algae then off-set the capital investment and on-going expenses of the CO2 capture technology by creating high value products from algae (i.e. bio-diesel, livestock feed and purified water). This process aims to ....Renewable energy from carbon dioxide: Process engineering to obtain bio-oil from algae. The Stern Report (2007)[1] has called for a CO2 REDUCTION BY MORE THAN 80% in 10-20 years to prevent profound changes in the climate over coming centuries. The proposed project will capture CO2 using algae then off-set the capital investment and on-going expenses of the CO2 capture technology by creating high value products from algae (i.e. bio-diesel, livestock feed and purified water). This process aims to be independently profitable regarless of future carbon taxes or carbon trading systems. This project also investigates water purification methods and new livestock feed additives which can help reduce the effects of drought on food producers in rural and regional areas. Read moreRead less
Miniaturised biosensors with high selectivity . This project aims to develop a technological platform for the fabrication of miniaturised and flexible sensors that enable the quantitative detection of important bioactive compounds such as fatty acids and biogenic amines. By utilising multi-enzymatic reactions in solid phase and engineering task-specific inks, chemiresistive sensors will be printed seamlessly as a whole. The sensors will respond to complex target biomolecules via a series of enzy ....Miniaturised biosensors with high selectivity . This project aims to develop a technological platform for the fabrication of miniaturised and flexible sensors that enable the quantitative detection of important bioactive compounds such as fatty acids and biogenic amines. By utilising multi-enzymatic reactions in solid phase and engineering task-specific inks, chemiresistive sensors will be printed seamlessly as a whole. The sensors will respond to complex target biomolecules via a series of enzymatic reactions through which the analyte will convert to much simpler, reactive and hence measurable molecules. This project will enable to design miniaturised sensors for point-of-care detection of biomolecules that cannot be yet evaluated by the end users.Read moreRead less
An Integrated Biotechnological Process for Production of Lactic Acid from Carbohydrate-Waste Streams by Rhizopus sp. Lactic acid is the most widely occurring multifunctional organic acid. It has enormous applications in food and food-related industries, and great potential use for production of biodegradable and biocompatible polylactate polymers. The aim of this research is to develop an innovative biotechnological process, incorporating simultaneous saccharification and fermentation, which int ....An Integrated Biotechnological Process for Production of Lactic Acid from Carbohydrate-Waste Streams by Rhizopus sp. Lactic acid is the most widely occurring multifunctional organic acid. It has enormous applications in food and food-related industries, and great potential use for production of biodegradable and biocompatible polylactate polymers. The aim of this research is to develop an innovative biotechnological process, incorporating simultaneous saccharification and fermentation, which integrates the production of lactic acid with the treatment of high strength food industry ?effluent? streams - carbohydrate waste streams. The proposed SSF process will cultivate an identified fungal Rhizopus sp strain on the waste streams, as production substrates, leading to an environmentally friendly and economically sustainable new technology for the food industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453935
Funder
Australian Research Council
Funding Amount
$220,106.00
Summary
Multi-Scale Fermentation Facility for Beverage Research. Australia's largest concentration of beverage fermentation research effort and infrastructure is arguably represented by the University of Adelaide and partners at the Waite Campus, particularly The Australian Wine Research Institute and Provisor Pty Ltd. This cluster seeks to establish an integrated, jointly managed, Multi-Scale Fermentation Facility for Beverage Research. This Facility will address critical shortages in fermentation capa ....Multi-Scale Fermentation Facility for Beverage Research. Australia's largest concentration of beverage fermentation research effort and infrastructure is arguably represented by the University of Adelaide and partners at the Waite Campus, particularly The Australian Wine Research Institute and Provisor Pty Ltd. This cluster seeks to establish an integrated, jointly managed, Multi-Scale Fermentation Facility for Beverage Research. This Facility will address critical shortages in fermentation capacity for research (volumes between 1 ml and 1000 L), offer a vertically integrated system to facilitate step-wise scale-up, allow more accurate modelling of industrial fermentations, enable greater adoption of high-throughput formats and technologies, and achieve enhanced productivity through increased system automation.Read moreRead less
Ex vivo production of neutrophils. Relentless infections frequently occur in patients receiving intensive chemotherapy treatment. Chemotherapy is toxic to the bone marrow where blood cells are produced. A low white blood cell count and in particular a low neutrophil count is linked with infection in these patients. Unlike red cells and platelets, neutrophils are difficult to collect from blood donors and hence are not routinely available. In this project, we will develop a practical, cost effic ....Ex vivo production of neutrophils. Relentless infections frequently occur in patients receiving intensive chemotherapy treatment. Chemotherapy is toxic to the bone marrow where blood cells are produced. A low white blood cell count and in particular a low neutrophil count is linked with infection in these patients. Unlike red cells and platelets, neutrophils are difficult to collect from blood donors and hence are not routinely available. In this project, we will develop a practical, cost efficient process for the production of neutrophils from cord blood. Transfusion of these neutrophils should reduce the chance of patients suffering serious infection, allow them to recover faster from their chemotherapy, and reduce the need for admission to intensive care.Read moreRead less
EX VIVO PRODUCTION OF MATURE RED BLOOD CELLS FOR TRANSFUSION. This project aims to establish a practical, cost efficient biotechnology platform for the expansion and maturation of blood stem cells to produce blood transfusion products. Red blood cell production will be used as the prototype model. It is envisaged that blood bioreactors will initially supplement and ultimately replace the current blood donor based process, thus overcoming the on-going donor recruitment, retention and safety issue ....EX VIVO PRODUCTION OF MATURE RED BLOOD CELLS FOR TRANSFUSION. This project aims to establish a practical, cost efficient biotechnology platform for the expansion and maturation of blood stem cells to produce blood transfusion products. Red blood cell production will be used as the prototype model. It is envisaged that blood bioreactors will initially supplement and ultimately replace the current blood donor based process, thus overcoming the on-going donor recruitment, retention and safety issues associated with collection of single units of blood. This project is focused on providing solutions to two key technical and economical challenges: (a) achieving full maturation of red blood cells and (b) achieving at least a 100-fold intensification of the expansion and maturation process through perfusion.Read moreRead less