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Remaking practices: learning to meet the challenge of practice change in primary health care. The improvement of primary health care delivery is an urgent national priority. This research will address the current lack of understanding of the new kinds of professional practices that are required to reshape primary health care in Australia. By focusing on the active role of learning and technology in the new practices, this research will provide theoretical and practical resources that will contri ....Remaking practices: learning to meet the challenge of practice change in primary health care. The improvement of primary health care delivery is an urgent national priority. This research will address the current lack of understanding of the new kinds of professional practices that are required to reshape primary health care in Australia. By focusing on the active role of learning and technology in the new practices, this research will provide theoretical and practical resources that will contribute to the achievement of professional practices that are multidisciplinary, integrated and patient-responsive. The outcomes of this research will benefit health service providers, health practitioners, patients and communities as well as policy makers engaged in the redesign of healthcare service delivery and health systems.Read moreRead less
Advancing understanding of health professionals' work and communication patterns and the effectiveness of work reform initiatives. Health systems internationally need to improve productivity and the way hospital staff work together. Yet we have surprisingly poor data about these and few measurement techniques. This project will deliver new methods, information and theoretical advances to support the design and evaluation of future workforce reform initiatives.
Implementing and evaluating the impact of the Carer Support Needs Assessment Tool (CSNAT) in community palliative care. The support needs of family caregivers at end of life will be assessed using a comprehensive tool and addressed by service providers to improve carers' psychological and physical wellbeing, carer burden, bereavement outcomes and the likelihood of the patient achieving their preferred place of death.
A prospective evaluation of the impact of the nurse practitioner role on emergency department service and outcomes. The local hospital emergency department (ED) is a prominent and highly utilised service in Australian communities but demand on EDs is increasing, resulting in significant service delays. This project will study the composition of ED clinical teams around Australia and their impact on improving the timeliness and quality of emergency clinical care.
Improved models to understand the genomic architecture of complex traits. This project aims to improve modelling of the genetics underlying complex traits. The project will develop and test models for using genome-wide genetic data to investigate how much heritability (genetic effect) underlies traits of interest, where it lies in the genome, and how much of it is shared across traits. The new models will be implemented in statistical algorithms in a freely-available software package. This proj ....Improved models to understand the genomic architecture of complex traits. This project aims to improve modelling of the genetics underlying complex traits. The project will develop and test models for using genome-wide genetic data to investigate how much heritability (genetic effect) underlies traits of interest, where it lies in the genome, and how much of it is shared across traits. The new models will be implemented in statistical algorithms in a freely-available software package. This project expects to increase understanding of biological mechanisms, the efficiency of genetic association analyses and the accuracy of genomic prediction, including the effects of interventions. The project will adapt human models to a wider range of organisms, in particular bacteria.Read moreRead less
Origami with triblock copolymers. This project aims to develop new nanoparticles structures with optimised shapes for biological applications. Most nanoparticles developed for drug delivery are spherical. However, these are not always the most efficacious as they often encounter problems penetrating the living cell. Viruses which have evolved to highly effectively invade living cells are often elongated. The project aims to mimic these structures by using the self-assembly of polymers. Expected ....Origami with triblock copolymers. This project aims to develop new nanoparticles structures with optimised shapes for biological applications. Most nanoparticles developed for drug delivery are spherical. However, these are not always the most efficacious as they often encounter problems penetrating the living cell. Viruses which have evolved to highly effectively invade living cells are often elongated. The project aims to mimic these structures by using the self-assembly of polymers. Expected outcomes include a better understanding how various sizes, shapes and surface groups of the prepared nanoparticles interact with cells. The knowledge could assist in the creation of better drug carriers for more efficient disease treatment.Read moreRead less
Battle of the sexes: can surroundings differentially affect male and female mammalian preimplantation embryos. Equality between the sexes is an issue even at conception. The environment surrounding the embryo can bias the development of one sex over another. This project will assist in the understanding of how male and female embryos differ and will improve assisted reproductive technologies for domestic animal breeding programs, endangered animal conservation and human infertility treatment.
Chemically re-engineering bioactive natural products using fragment based drug design. Current drug and agrichemical discovery technologies are under immense pressure to meet the future pharmaceutical and agriculture demand created by population growth. This project will develop a novel technology concept that re-engineers the chemical features of bioactive natural products optimising medicine and agrichemical discovery.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100011
Funder
Australian Research Council
Funding Amount
$346,439.00
Summary
Spinning disk confocal microscope with dual stages. Spinning disk confocal microscope with dual stages: This custom-built spinning disk confocal microscope with rotational stages will constitute an internationally unique platform. The system has the capability of rapidly monitoring cells in growing biological specimens under changing environments. It offers an integrated platform for multiple imaging strategies, including confocal and Total Internal Reflection Fluorescence (TIRF) microscopy. The ....Spinning disk confocal microscope with dual stages. Spinning disk confocal microscope with dual stages: This custom-built spinning disk confocal microscope with rotational stages will constitute an internationally unique platform. The system has the capability of rapidly monitoring cells in growing biological specimens under changing environments. It offers an integrated platform for multiple imaging strategies, including confocal and Total Internal Reflection Fluorescence (TIRF) microscopy. The system will reside in core facilities with open access to a broad research community. The system may be used to monitor a wide variety of cells and molecules, and will offer capabilities that are of importance to understand cell trafficking, disease and signalling, plant biomass production, and climate change.Read moreRead less
Improving plant productivity and human health using next generation biotechnology approaches. Both medical and plant sciences face similar technological problems in harnessing the power of modern DNA sequencing for accelerating the pace of beneficial gene function discovery. Plant and animal researchers will collaborate in this program to meet this common challenge. The research outcomes envisaged in this proposal will benefit human health by enabling more rapid discovery of genes related to obe ....Improving plant productivity and human health using next generation biotechnology approaches. Both medical and plant sciences face similar technological problems in harnessing the power of modern DNA sequencing for accelerating the pace of beneficial gene function discovery. Plant and animal researchers will collaborate in this program to meet this common challenge. The research outcomes envisaged in this proposal will benefit human health by enabling more rapid discovery of genes related to obesity, immunity, fertility, neurological function and cancer. In the plant sphere, the outcomes will shed new light on plant functions related to plant energy metabolism, vitamin biosynthesis drought tolerance and water use by crops. The research will benefit both human health and agricultural food production and quality.Read moreRead less