Generation Of Protective Immunity Against Severe Influenza Disease In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$1,630,970.00
Summary
Hospitalisation and death rates from influenza are high in the Indigenous population, especially when a new virus emerges. There is an urgent need for a vaccine that protects against all influenza strains. T cells recognising conserved viral regions elicit such protection. As T cells are restricted by proteins called HLAs, which vary across ethnicities, we will define T cell regions for HLAs prominent in Indigenous Australians and define how to generate protective immunity against influenza.
Understanding Influenza-specific T Cell Immunity In The Indigenous Population
Funder
National Health and Medical Research Council
Funding Amount
$870,112.00
Summary
Hospitalisation and death rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. T cells recognising conserved viral regions can elicit such protection. As T cells are restricted by proteins called HLAs, variable between different ethnicities, we will define T cell regions and their HLA restrictions in the Indigenous population to propose strategies for universal T cell-based protecti ....Hospitalisation and death rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. T cells recognising conserved viral regions can elicit such protection. As T cells are restricted by proteins called HLAs, variable between different ethnicities, we will define T cell regions and their HLA restrictions in the Indigenous population to propose strategies for universal T cell-based protective immunity and vaccine design against influenza.Read moreRead less
The Burden And Risk Factors Of Depressive Disorders In Indigenous Australians: Implications For Early Detection And Prevention
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This Fellowship addresses the high rates of depression amongst Indigenous Australians. The proposed work will quantify the extent to which two major risk factors contribute to the burden of depression in this population and the burden avertable from interventions to modify these risk factors. Findings would inform resource allocation and health service delivery, and in doing so, present opportunities for improvements in the health of Indigenous Australians.
Improved Businesss Decision-Making via Liquid Process Model Collections. This project aims to develop an innovative approach to create and update as necessary the large collection of business process models that represent a complex organisation, so that this collection captures the actual way in which the organisation performs its business processes. Deploying theoretical, conceptual and empirical research, this project aims to capitalise on the value hidden in large process data, as recorded in ....Improved Businesss Decision-Making via Liquid Process Model Collections. This project aims to develop an innovative approach to create and update as necessary the large collection of business process models that represent a complex organisation, so that this collection captures the actual way in which the organisation performs its business processes. Deploying theoretical, conceptual and empirical research, this project aims to capitalise on the value hidden in large process data, as recorded in event logs. The approach is intended to be implemented in an open-source technology to facilitate advanced investigations and predictions that can ultimately lead to better strategic decision-making. This technology also has the potential to become a research-enabling tool for the large research community in business process management.Read moreRead less
Cost-aware business process management. The project aims to inform business process management (BPM) with the latest insights from the field of management accounting in order to make BPM systems cost-aware. By incorporating the cost dimension, organisations can obtain an accurate and immediate overview of the true cost of their processes and make cost-informed decisions.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561221
Funder
Australian Research Council
Funding Amount
$142,450.00
Summary
Australian Virtual Observatory. The explosion in the rate of data acquisition in disciplines such as Astronomy requires new database structures and management systems. Scientists need fast access and analysis of data from many diverse telescopes, instruments and theoretical modeling packages. In 2005, we will begin the critical process of unifying the different aspects of the Australian Virtual Observatory based on GrangeNet. This program is complementary to and builds on substantial investm ....Australian Virtual Observatory. The explosion in the rate of data acquisition in disciplines such as Astronomy requires new database structures and management systems. Scientists need fast access and analysis of data from many diverse telescopes, instruments and theoretical modeling packages. In 2005, we will begin the critical process of unifying the different aspects of the Australian Virtual Observatory based on GrangeNet. This program is complementary to and builds on substantial investments in Europe, the US and the UK to develop the International Virtual Observatory. The Australian Virtual Observatory will be a key demonstrator for Australia's information infrastructure.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453677
Funder
Australian Research Council
Funding Amount
$308,700.00
Summary
Australian Astronomy Grid. An explosion in the rate of data acquisition in disciplines such as Astronomy will require new database structures and management systems. Scientists need fast access and analysis of data from many diverse telescopes, instruments and theoretical modeling packages. In 2004, we will start building the Australian Astronomy Grid based on GrangeNet,including at least three nodes. This program is complementary to and builds on substantial investments in Europe, the US and ....Australian Astronomy Grid. An explosion in the rate of data acquisition in disciplines such as Astronomy will require new database structures and management systems. Scientists need fast access and analysis of data from many diverse telescopes, instruments and theoretical modeling packages. In 2004, we will start building the Australian Astronomy Grid based on GrangeNet,including at least three nodes. This program is complementary to and builds on substantial investments in Europe, the US and the UK to develop the International Virtual Observatory. The Australian Astronomy Grid will be a key demonstrator for Australia's information infrastructure.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668442
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
The Australian Virtual Observatory. The Australian Virtual Observatory, which is part of the International Virtual Observatory is an ambitious program to consolidate all astronomical data online, in a form which will be accessible to both professional astronomers and also to the wider public. The project will link data, computational resources, high level software and people in an advanced network, which will maximise investment in one of Australia's highest profile scientific programs.
CENTRE OF RESEARCH EXCELLENCE TO REDUCE INEQUALITY IN HEART DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$2,607,253.00
Summary
There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health ....There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health care services.Read moreRead less