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Micromechanical analysis of size segregation and its prediction in granular free-surface flows. Industries often suffer from size segregation in the handling and processing of granular materials, leading to significant economic consequences. This project aims to develop a fundamental understanding of size segregation and prediction models, enabling industries to eliminate, minimise, or manage the effects to an acceptable level.
Optical tweezers as a micro-rheological probe of soft surfaces. Biomembranes are more than soft containers - their dynamic flexibility plays an important role in cell function, but measurements of mechanical properties of soft surfaces are non-existent. This project develops and applies a new optical tweezers method to measure the flexibility of membranes and its effects upon the friction of nearby particles.
Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour ....Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour requirement, higher production rate and better quality control than conventional production methods. The new process will combine benefits from both supercritical fluid technology (green process) and microfluidics (high mass & heat transfer).Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100082
Funder
Australian Research Council
Funding Amount
$408,000.00
Summary
Nanostructures derived from metal-organic frameworks for sodium-ion batteries. This project aims to overcome poor reaction kinetics and the lack of effective anode materials owing to the large size of sodium-ions in high performance sodium-ion batteries. The project will explore a series of functional nanomaterials with unique nanostructures and complex compositions, enabled by metal-organic framework assisted synthetic methods. High performance sodium ion batteries are demonstrating great poten ....Nanostructures derived from metal-organic frameworks for sodium-ion batteries. This project aims to overcome poor reaction kinetics and the lack of effective anode materials owing to the large size of sodium-ions in high performance sodium-ion batteries. The project will explore a series of functional nanomaterials with unique nanostructures and complex compositions, enabled by metal-organic framework assisted synthetic methods. High performance sodium ion batteries are demonstrating great potential to meet the future demand for large-scale and low-cost stationary energy storage. However, their practical implementation is still hindered by their poor reaction kinetics and the lack of effective anode materials owing to the large size of sodium-ions. The project outcomes will promote the commercialisation of sodium ion batteries and power Australia’s sustainable economy in the long run.Read moreRead less
Engineering defect-intensive ozonation catalysts to degrade micropollutants. This project aims to engineer unique particles containing defect-intensive surfaces which are designed to accelerate the catalytic ozonation of waters contaminated with pharmaceuticals and other recalcitrant pollutants. This will enable timely treatment of industrial waste water as well as sewerage treatment plant effluents using simple and cheap catalyst materials. Wet- and flame-based particle fabrication technologies ....Engineering defect-intensive ozonation catalysts to degrade micropollutants. This project aims to engineer unique particles containing defect-intensive surfaces which are designed to accelerate the catalytic ozonation of waters contaminated with pharmaceuticals and other recalcitrant pollutants. This will enable timely treatment of industrial waste water as well as sewerage treatment plant effluents using simple and cheap catalyst materials. Wet- and flame-based particle fabrication technologies paired with unique post-synthesis treatment strategies, including either a coupled hydrogenation-illumination approach or plasma exposure, will be implemented for defect manipulation so as to produce new cheaper, stable, and higher-performing catalysts for activating ozone to treat water containing pharmaceutical and endocrine disrupting micro-pollutants under different process conditions.Read moreRead less
Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Unravelling the mechanics of particle deposition at the micro-scale. This project aims to discover the mechanisms responsible for the interactions between aerosol particles and surfaces in a range of air flow conditions. The project expects to transform our understanding of particle deposition through a combination of novel laser-based diagnostic techniques, optical coherence tomography, and state of the art particle formulation methodologies. Expected outcomes of the project include delivery of ....Unravelling the mechanics of particle deposition at the micro-scale. This project aims to discover the mechanisms responsible for the interactions between aerosol particles and surfaces in a range of air flow conditions. The project expects to transform our understanding of particle deposition through a combination of novel laser-based diagnostic techniques, optical coherence tomography, and state of the art particle formulation methodologies. Expected outcomes of the project include delivery of new methods to optimise particle deposition, development of tunable powder formulations, as well as definition of particle-surface interaction mechanisms in flows. The project should provide significant benefits to particle systems for applications ranging from additive manufacturing to aerosol delivery.Read moreRead less
Next generation core-shell materials based on biomolecular dual-templating. This project aims to discover and develop new methods and knowledge for the precision engineering of next-generation core-shell materials using sustainable biomolecular dual-templating processes. This research builds on a recent breakthrough - emulsion and biomimetic dual-templating technology for facile preparation of silica capsules, and is expected to revolutionise current approaches for making core-shell materials. S ....Next generation core-shell materials based on biomolecular dual-templating. This project aims to discover and develop new methods and knowledge for the precision engineering of next-generation core-shell materials using sustainable biomolecular dual-templating processes. This research builds on a recent breakthrough - emulsion and biomimetic dual-templating technology for facile preparation of silica capsules, and is expected to revolutionise current approaches for making core-shell materials. Significant outcomes are expected to be achieved through building fundamental understanding around this breakthrough, including new concepts for hierarchical nanomaterials based on biomolecular design, new molecular and engineering design rules for core-shell materials, and novel materials for applications in sustained release and delivery systems.Read moreRead less
High value micron-sized particles from a novel antisolvent vapour spray drying system. Convective antisolvent precipitation is a novel route in producing particles from spray drying by adding an anti-solvent to the drying medium. This project will allow conventional spray dryers to produce more sophisticated ultrafine and encapsulated particles for use in food, pharmaceuticals and other high value applications.
Use of Gas Expanded Liquids to Facilitate Process Intensification. The aim of this research is the utilisation of gas expanded liquids (GXLs) in technology platforms based on the principles of process intensification (PI). In order to facilitate the attainment of project objectives a comprehensive investigation of the fundamental properties of GXLs, and their interactions is proposed. A significant component of the programme is expected to be to use the knowledge obtained to facilitate the devel ....Use of Gas Expanded Liquids to Facilitate Process Intensification. The aim of this research is the utilisation of gas expanded liquids (GXLs) in technology platforms based on the principles of process intensification (PI). In order to facilitate the attainment of project objectives a comprehensive investigation of the fundamental properties of GXLs, and their interactions is proposed. A significant component of the programme is expected to be to use the knowledge obtained to facilitate the development of scale-up protocol for PI based methodologies, with particular emphasis on the production of biomaterials. GXLs technology is frontier technology with regard to the biomaterials sector.Read moreRead less