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Revealing the beneficial effects of acoustic stimulation on the human brain. This project aims to provide greater understanding of the neural mechanisms by which initiation of motor responses can be improved by unexpected auditory stimulation. Initiating motor actions appears natural and effortless, but is underpinned by complex neural mechanisms that are not well understood. Using novel brain stimulation techniques, the project aims to assess the potential for properly timed strong sensory stim ....Revealing the beneficial effects of acoustic stimulation on the human brain. This project aims to provide greater understanding of the neural mechanisms by which initiation of motor responses can be improved by unexpected auditory stimulation. Initiating motor actions appears natural and effortless, but is underpinned by complex neural mechanisms that are not well understood. Using novel brain stimulation techniques, the project aims to assess the potential for properly timed strong sensory stimulation during movement preparation to induce neural plasticity and motor learning. This knowledge would have important implications across a number of fields, including neuroscience, sports science, and applied ergonomics.Read moreRead less
The secret of tiny hand movements to feel and manipulate objects. This study aims to reveal some of the fundamental sensory mechanisms underlying the uniquely human ability to manipulate objects and use tools. Signals from touch receptors are crucial for controlling grip forces so that delicate objects are held without slipping, or being crushed by excessive force. Yet we know little about how such sensory information is obtained and how it is used for the motor control. By analysing hand moveme ....The secret of tiny hand movements to feel and manipulate objects. This study aims to reveal some of the fundamental sensory mechanisms underlying the uniquely human ability to manipulate objects and use tools. Signals from touch receptors are crucial for controlling grip forces so that delicate objects are held without slipping, or being crushed by excessive force. Yet we know little about how such sensory information is obtained and how it is used for the motor control. By analysing hand movements during object manipulation and recording sensory signals from single human nerve fibres we will investigate how certain types of movement shape richness of available sensory information. This knowledge will facilitate the development of next generation sensory-controlled prosthetics and robotic manipulators.Read moreRead less
Determining the neural mechanisms of visual stimuli and motor responses. This project aims to determine how we select actions to visual cues rapidly, unconsciously and automatically. Learning associations between visual stimuli and motor responses is part of normal development and continues throughout life. Rapid deployment of these actions is often critical for safety yet we have limited knowledge of how the human brain does this. This project will use neuroimaging tools to characterise the spa ....Determining the neural mechanisms of visual stimuli and motor responses. This project aims to determine how we select actions to visual cues rapidly, unconsciously and automatically. Learning associations between visual stimuli and motor responses is part of normal development and continues throughout life. Rapid deployment of these actions is often critical for safety yet we have limited knowledge of how the human brain does this. This project will use neuroimaging tools to characterise the spatial and temporal neural architecture underlying these processes and determine how the dorsal and ventral streams of visual processing, specialised for motor control and recognition respectively, interact in vision-based actions as these actions become learned.Outcomes will provide new frameworks for driving improvement in any domain in which goal-directed actions depend on the rapid processing of visual information, including human-machine interfaces for defence, economic development, education, health, science and technology.Read moreRead less
Structural and neural determinants of stress and strain in human muscle. This project aims to further our understanding of the biomechanical stress and strains experienced by contracting human muscles. Using innovative imaging techniques such as microendoscopy and supersonic shear imaging, we expect to generate new significant evidence on the structural and neural factors that lead to areas of high stress in human muscles. Outcomes of this project include not only a new understanding of muscle d ....Structural and neural determinants of stress and strain in human muscle. This project aims to further our understanding of the biomechanical stress and strains experienced by contracting human muscles. Using innovative imaging techniques such as microendoscopy and supersonic shear imaging, we expect to generate new significant evidence on the structural and neural factors that lead to areas of high stress in human muscles. Outcomes of this project include not only a new understanding of muscle design on multi-scale level, but also of muscle function and adaptation. This should provide significant benefits in better predicting muscle injury and prescribing safe exercise, knowledge that would benefit biomechanical engineers and sport and exercise professionals.Read moreRead less
How do past actions and rewards bias goal directed movement? This project aims to identify how different aspects of our past experience affect the accuracy of movements, and study the underlying brain mechanisms. This project will use timing methods and brain recordings to test how the history of movements we have executed in the past, and the rewards associated with those movements, interact to affect subsequent movement execution. The project should advance basic understanding of how the human ....How do past actions and rewards bias goal directed movement? This project aims to identify how different aspects of our past experience affect the accuracy of movements, and study the underlying brain mechanisms. This project will use timing methods and brain recordings to test how the history of movements we have executed in the past, and the rewards associated with those movements, interact to affect subsequent movement execution. The project should advance basic understanding of how the human brain controls movement, and provide theoretical foundations needed to improve the design of human-machine interfaces, and training approaches in industry, rehabilitation and sport.Read moreRead less
A common sub-cortical system for human eye and limb control. This project aims to discover how the human brain controls reaching movements via structures and control mechanisms used for rapid eye movements, and for prey capture by lower vertebrates such as fish. Fast and accurate visually-guided movement was crucial for survival long before animals evolved a cerebral cortex, suggesting that basic control systems may be conserved across species. The notion that primitive sub-cortical systems can ....A common sub-cortical system for human eye and limb control. This project aims to discover how the human brain controls reaching movements via structures and control mechanisms used for rapid eye movements, and for prey capture by lower vertebrates such as fish. Fast and accurate visually-guided movement was crucial for survival long before animals evolved a cerebral cortex, suggesting that basic control systems may be conserved across species. The notion that primitive sub-cortical systems can control complex, human limb movements challenges conventional thinking about movement-related brain activity, and has important implications for the design of human-machine interfaces and training protocols in rehabilitation, industry and sport.Read moreRead less
Molecular switches and genetic consequences of grain retention in cereals. Grain retention at maturity was key for crop domestication and laid the basis for farming. Wheat and barley have evolved a novel mechanism for ensuring grain retention and, although the genes are known, the mechanisms for action are not. Grain dispersal in the wild relatives involves highly targeted changes in the walls of a small number of cells. This project will explore how the two identified genes control this proces ....Molecular switches and genetic consequences of grain retention in cereals. Grain retention at maturity was key for crop domestication and laid the basis for farming. Wheat and barley have evolved a novel mechanism for ensuring grain retention and, although the genes are known, the mechanisms for action are not. Grain dispersal in the wild relatives involves highly targeted changes in the walls of a small number of cells. This project will explore how the two identified genes control this process and clarify their mode of action. The genes ensuring grain retention have been so critical for domestication that the region surrounding them has become genetically fixed. The project will assess the implication of fixation on genetic diversity and develop options to bring novel variation into breeding programs.Read moreRead less
How brain oscillations influence our behaviour. This project aims to reveal how sudden, intense stimuli impair or facilitate concurrent actions. Startling sounds can disrupt the execution of movements and distract attention from vital events in the environment, with potential disastrous consequences when handling complex equipment such as airplanes, cars and trucks, or surgical instruments. This project will combine classic experimental and novel neuro-modulatory techniques with the measurement ....How brain oscillations influence our behaviour. This project aims to reveal how sudden, intense stimuli impair or facilitate concurrent actions. Startling sounds can disrupt the execution of movements and distract attention from vital events in the environment, with potential disastrous consequences when handling complex equipment such as airplanes, cars and trucks, or surgical instruments. This project will combine classic experimental and novel neuro-modulatory techniques with the measurement of oscillatory brain activity. Expect outcomes will inform theories of cognitive function and the design of interventions to reduce the negative effects of sudden, distracting events.Read moreRead less
Learning control and computational models of human motor systems. With the aim of understanding how humans learn their body movements, this project addresses fundamental cross-disciplinary issues of learning control, robotics and computational models of human motor systems. The results will lead to improvements in smart industrial automation and the development of more effective rehabilitation stategies.
Subcortical control of human reaching? This project will test a radical new hypothesis about how the human brain generates visually guided behaviour. Conventional thinking assumes that visuomotor control of limb movements occurs exclusively within the cerebral cortex. However, the project team’s recent observations of extremely rapid visually guided muscle activity strongly imply that the human brain controls reaching movements via more primitive midbrain and brainstem structures. The project’s ....Subcortical control of human reaching? This project will test a radical new hypothesis about how the human brain generates visually guided behaviour. Conventional thinking assumes that visuomotor control of limb movements occurs exclusively within the cerebral cortex. However, the project team’s recent observations of extremely rapid visually guided muscle activity strongly imply that the human brain controls reaching movements via more primitive midbrain and brainstem structures. The project’s hypotheses challenge long-standing ideas about the functional organisation of the human brain and may have wide-ranging implications for the design of human-machine interfaces as well as training protocols in rehabilitation, industry, and sport.Read moreRead less