The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
In autoimmune diseases the immune system attacks the body’s own tissues. Although we know that both genetic and environmental factors contribute to the risk of disease, identifying these genes and the environmental factors involved is very difficult. Furthermore, we have almost no idea how these factors interact with each other, something we need to understand in order to predict the risk of disease and reliably identify possible therapies. These are the aims of this fellowship.
Understanding Determinant Selection In Autoimmune Diseases
Funder
National Health and Medical Research Council
Funding Amount
$686,656.00
Summary
Understanding what the immune system perceives during infection or in autoimmunity is key to the development of improved vaccines and therapies for a variety of human diseases. This proposal builds on leading research into the definition of targets of immunity in autoimmune diseases using cutting edge proteomic technologies. The proposal focuses on type 1 diabetes, multiple sclerosis, lupus and rheumatoid arthritis and will delineate candidate therapeutic molecules.
My research is directed to the prevention of type 1 diabetes, based on understanding immune-inflammatory mechanisms that contribute to dysfunction of insulin-secreting beta cells and tissue resistance to the action of insulin. I study these mechanisms in rodent models and in humans with the aim of manipulating them for therapeutic benefit. I am particularly interested in understanding environment-gene interactions mediated by epigenetic modifications.
Dissecting Human B-cell Function: From Primary Immunodeficiencies To Chronic Inflammatory Disease
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
Despite knowing a lot about immunity in a mice, functional analysis of the human immune system has been a major challenge. I will study defects of immune cells in humans with gene mutations that cause an antibody deficiency. With new insights from these unique clinical samples, I will functionally dissect human immune responses, directly translate these to chronic inflammatory disease, and provide implications for future vaccine development and cancer treatment.
Immunological Diseases: Understanding Their Cause And Improving Their Treatment By Human Genome Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$788,486.00
Summary
Prof Goodnow will develop a collaborative consortium of specialist physicians, laboratory researchers and bioinformaticians. This team will apply the new tools of large scale DNA sequencing to reveal the root cause of immune system diseases including: autoimmune diseases, congenital immune deficiency diseases, allergic disorders, and cancer. It aims to accelerate, simplify and unify the diagnosis of these diseases, and guide targeted, earlier and more effective treatment.
As a molecular geneticist, I am interested in how and why genetic mutations occur, how these changes cause disease or disease predisposition, and ways of better treating and monitoring genetic disease. The ‘model diseases’ I am most interested in are blood cell diseases such as autoimmunity (e.g. arthritis) and leukaemias.
Control Of Pathogenic Antibody Responses In Humans
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
Deficient or inappropriate antibody responses are at the core of many autoimmune diseases, allergies, food intolerances, and often explain the failure of vaccination strategies. Specialised follicular T cells control the quality of antibodies produced by B cells. This fellowship will combine basic studies investigating B cell helper or regulatory follicular T cells in humans with genetic studies identifying the causes of autoantibody-driven diseases. The results will uncover targeted therapies.
My goal is to develop substantial Australian capacity and international leadership in research on Health Impacts of Environment and Climate Change. Climate change poses diverse health risks, both direct (heatwaves, weather disasters, drought, urban air quality) and indirect (infectious disease patterns, food yields, economic loss, environmental refugee flows). My research group, with my own international connections and our strong cross-campus and external collaborative links, is ideally placed ....My goal is to develop substantial Australian capacity and international leadership in research on Health Impacts of Environment and Climate Change. Climate change poses diverse health risks, both direct (heatwaves, weather disasters, drought, urban air quality) and indirect (infectious disease patterns, food yields, economic loss, environmental refugee flows). My research group, with my own international connections and our strong cross-campus and external collaborative links, is ideally placed to do this research. Major outcomes will be: (i) enhanced understanding of the health risks from climate change and other human-induced environmental changes (including studies of their influences on patterns of infectious diseases); (ii) a broader evidence base for developing preventive-adaptive strategies to lessen health risks – and further development of my Centre’s high-level skills in translating research to social policy. My four specific aims are to: 1. Extend our research on the health impacts of climate change and other environmental changes. This will include strengthening further our international collaboration, developing new methods, and: (a) research on the health impacts of long-term drought in rural Australia; (b) elucidating the interplay of environmental, climatic, social and economic influences on infectious disease emergence and spread in the Australia-Asia region (to enhance ecological understanding, facilitate prevention-control strategies, and advance the biosecurity research agenda – including via ANU’s new Centre for Biosecurity). 2. Develop further our research on environmental and genetic influences on immune system function and autoimmune diseases, including studying the role of vitamin D. Answers to these research questions will be generalisable to the prevention and management of immune disorders. 3. Provide strong leadership in fostering international research activities, capacity and collaboration on the health impacts of global environmental-climatic changes (GEC). I have special opportunity and responsibility as co-chair of the International Council of Science project: ‘GEC and Human Health’. 4. Develop Australia’s population health research capacity with emphasis on training early-mid-career researchers. This fellowship research program would be greatly strengthened by retention of several high-performing and committed Team Investigators already working in the topic area. My central objective is to consolidate national research capacity and long-term momentum in the above areas, with high international engagement and profile. Under my directorship NCEPH has attained high visibility in: (i) climate change and health research; (ii) modeling infectious disease transmission and control; (iii) studying the environmental aetiology of immune disorders; and (iv) social-cultural epidemiological research into influences on health-reRead moreRead less