Investigation Of Molecular And Cellular Determinants Of Immune Related Adverse Events Following Treatment With Immune Checkpoint Inhibitors
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Novel immune-based treatments for advanced, incurable, cancer have significantly improved patient survival. Although these treatments have proven highly effective, they are associated with the unpredictable development of severe and sometimes life-threatening autoimmune disease. We aim to discover ways to predict and potentially prevent these complications by identifying genetic risk factors and markers in blood samples. If successful, this will be a ground breaking advance in cancer care.
Explaining The Selection Of Gluten Peptides Toxic In Coeliac Disease
Funder
National Health and Medical Research Council
Funding Amount
$704,117.00
Summary
Immune response genes shape the molecular specificity of immune responses, and some play a critical role in causing disease. Coeliac disease caused by gluten in food is very tighly linked to such genes. Discovery of the components of gluten in each genetic variant of coeliac disease will allow us to study how the gluten immune reaction in coeliac disease is controlled, and will be the basis of better diagnostic tests and therapies.