ANTIGEN PRESENTATION IN CEREBRAL MALARIA PATHOGENESIS: A ROLE FOR BRAIN MICROVASCULAR ENDOTHELIUM AND MICROPARTICLES
Funder
National Health and Medical Research Council
Funding Amount
$416,012.00
Summary
We want to better understand how lesions occur in the brain during cerebral malaria. We focus our attention on the cells lining the brain blood vessels, called endothelial cells. The originality of this project is to study endothelial cells as immune cells. We already showed that they carry molecules enabling them to activate T lymphocytes and trigger inflammation. Knowing the fine mechanisms by which small brain vessels become damaged will help design better treatments for neuroinflammation.
Immunotherapeutic Strategies In Anti Myeloperoxidase ANCA Associated Glomerulonephritis
Funder
National Health and Medical Research Council
Funding Amount
$615,998.00
Summary
Kidney disease is the 10th most common cause of death in Australia. Glomerulonephritis (GN) is a major cause of kidney disease. Autoimmunity underpins disease in most patients with the most severe forms. Following the discovery of the peptide that is the target of this autoimmunity promising new biological treatments are possible. This grant will assess the capacity of four emerging therapies to turn off injurious autoimmunity and treat disease.