Perforin Trafficking And Activation In Killer Lymphocytes
Funder
National Health and Medical Research Council
Funding Amount
$292,639.00
Summary
Perforin (PRF) is a protein essential for the function of cytotoxic lymphocytes during an immune response in humans. Humans deficient in PRF are severely immunosuppressed and fall critically ill if they contract a viral infection. The partial loss of PRF function can also predispose an individual to cancer. We aim to investigate the functional and biochemical properties of PRF. The outcomes of this study will determine how PRF influences the immune system and immune homeostasis in humans.
The Genetics And Mechanisms Of Resistance To The Zoonotic Highly Pathogenic Influenza Virus In Avian Species
Funder
National Health and Medical Research Council
Funding Amount
$337,373.00
Summary
Highly pathogenic avian influenza (HPAI) poses a serious pandemic risk. This project will investigate the genetic basis and mechanisms underlying resistance to HPAI in birds. It will explore the role of immune genes in resistance to HPAI in six bird species which vary in their susceptibility to HPAI. Functional tests of resistance genes will be performed to determine how these genes can provide resistance to HPAI. This study will assist in the development of strategies to mitigate disease risks.
Tracking B Cell And Neutralising Antibody Responses In Hepatitis C Virus Infections
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Hepatitis C virus is one of the most significant human pathogens. There is no vaccine for HCV, and the antiviral treatment is expensive and does not stop reinfection. This project will study how the immune system of people infected with HCV generates antibodies to clear the virus. This will inform research efforts to design successful preventative vaccine to protect against this viral pathogen.
The Consequences Of Innate Anti-viral Effector Responses On Reproductive Outcomes In Placental Mammals
Funder
National Health and Medical Research Council
Funding Amount
$328,060.00
Summary
The mother's immune system can tolerate the growth of an ostensibly foreign fetus during pregnancy. We will investigate whether exposure to viral infections either just before or during pregnancy can result in reduced fertility and whether it may affect fetal growth and development. These results will contribute in designing effective interventions to limit any potential detrimental outcomes.
T Cell Trafficking And Effective Immunotherapy For Cancer
Funder
National Health and Medical Research Council
Funding Amount
$218,807.00
Summary
Cancer is the major cause of death in Australia in 2007. New forms of treatment are needed. The body’s defences against infection can be harnessed to fight some cancers. This project will examine how we can do this better using the signals that tell the body’s killer cells where to go and what to do when they get there.
The Impact Of Reduced Plasmodium Falciparum And Plasmodium Vivax Transmission On The Epidemiology Of Malaria And The Acquisition Of Antigen-specific Recall Responses In Children From Papua New Guinea.
Funder
National Health and Medical Research Council
Funding Amount
$365,166.00
Summary
Malaria represents a significant global health burden in endemic countries. Individuals gradually develop a level of immunity to the clinical symptoms of malaria as a result of continued exposure throughout their lifetime. Efforts to implement effective malaria control strategies are increasing, thereby reducing exposure. This project will investigate how such strategies will impact on the development of immunity to malaria and the amount of clinical disease observed in different age groups.
Changing Patterns Of Immunity Following Large Scale Malaria Control Programs In The South West Pacific
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
People can develop partial immunity to malaria, which requires ongoing exposure to infection to be maintained. If exposure to infections is completely prevented, people can lose the immunity it has taken them years to develop. In the context of significant ongoing malaria bednet control efforts in the South West Pacific, we will investigate loss or maintenance of the malaria-immune state. This is important for vaccine development and to help us define risk of rebound disease.