De Novo Mutations And The Pathogenesis Of Childhood-onset Autoimmune Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,406,510.00
Summary
This project aims to reveal the gene abnormalities that cause devastating autoimmune diseases to develop in some children, such as Type 1 diabetes, juvenile arthritis and autoimmune destruction of blood cells. The project will use new technologies to identify alterations in the DNA sequence of a child compared to either of their parents, and to test suspicious DNA alterations in laboratory mice in order to understand the gene effects and evaluate new treatments.
Industrial Transformation Training Centres - Grant ID: IC220100035
Funder
Australian Research Council
Funding Amount
$4,958,927.00
Summary
ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, ....ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, providing the materials and inspiration for young researchers to apply novel hyphenated methods to complex environmental and industrial systems. This Centre will deliver fundamental developments in hyphenated technologies, new analytical capability, and applied outcomes across multiple end-user groups and interests. Read moreRead less
Modifying The Trajectory Of Insidious Late Life Cognitive Decline Using Computerised Cognitive Training
Funder
National Health and Medical Research Council
Funding Amount
$743,152.00
Summary
Supervised, group-based computerised cognitive training (CCT) is a safe and effective intervention to maintain cognition in healthy older adults. This project will examine the extent to which CCT can attenuate or even reverse the rate of decline in older people with previously documented cognitive decline, as well as strategies to maintain CCT effects in the long term.
Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encodi ....Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encoding and retrieval processes, the model can assess how changes in different sources of interference modulate performance through the trajectory of early development. Hierarchical Bayesian estimation aims to enable a simultaneous account of multiple tasks and support future deployment in applied contexts.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100056
Funder
Australian Research Council
Funding Amount
$3,975,864.00
Summary
ARC Training Centre for Next-Gen Technologies in Biomedical Analysis . The Centre for Next-Gen Technologies in Biomedical Analysis will deliver workforce trained in the development of transformative technologies that will rapidly expand the Australian pharmaceutical, diagnostic and defence sector. The university-industry partnership will increase Australia’s manufacturing capability by fast tracking screening, by integrating 3D printing, advanced sensing, big data analytics, machine learning an ....ARC Training Centre for Next-Gen Technologies in Biomedical Analysis . The Centre for Next-Gen Technologies in Biomedical Analysis will deliver workforce trained in the development of transformative technologies that will rapidly expand the Australian pharmaceutical, diagnostic and defence sector. The university-industry partnership will increase Australia’s manufacturing capability by fast tracking screening, by integrating 3D printing, advanced sensing, big data analytics, machine learning and artificial intelligence for the delivery of optimal solutions in diagnosis, treatment and wellbeing. The centre will deliver training in Industry 4.0 skills which will boost early-stage scale-up and accelerate the sector’s supply chain, which is pivotal for the Australian industries to maintain a competitive edge. Read moreRead less
The Psychology of Misinformation—Towards A Theory-driven Understanding. The project aims to develop a psychological theory of misinformation effects. Misinformation influences people’s memory, reasoning and decision-making even after corrections – it thus poses a significant challenge for science and society. Through the combination of systematic experimentation with theory-driven computational modelling, the project will strive to concurrently consider individual-level cognition and the impact ....The Psychology of Misinformation—Towards A Theory-driven Understanding. The project aims to develop a psychological theory of misinformation effects. Misinformation influences people’s memory, reasoning and decision-making even after corrections – it thus poses a significant challenge for science and society. Through the combination of systematic experimentation with theory-driven computational modelling, the project will strive to concurrently consider individual-level cognition and the impact of sociocultural context. It is anticipated that this novel integrative approach will substantially expand our understanding of misinformation effects, and that this theoretical progress will result in the formulation of specific communication strategies to reduce the impact of misinformation on society.Read moreRead less
Special Research Initiatives - Grant ID: SR0354596
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Perception and Action in Auditory Scenes (PAAS): Neural, Behavioural, Computational and Mechanical Systems. Auditory scenes are temporal and ephemeral yet pervasively influence human life. How humans negotiate such scenes has not been solved, a fact highlighted by attempts to build machines to respond to speech, warnings etc., in real-world situations with room reverberation, different talkers, and background noise. No one discipline can solve such problems. In this network outstanding researche ....Perception and Action in Auditory Scenes (PAAS): Neural, Behavioural, Computational and Mechanical Systems. Auditory scenes are temporal and ephemeral yet pervasively influence human life. How humans negotiate such scenes has not been solved, a fact highlighted by attempts to build machines to respond to speech, warnings etc., in real-world situations with room reverberation, different talkers, and background noise. No one discipline can solve such problems. In this network outstanding researchers from physical, medical, human, and social sciences with interests in speech, music and audition will provide insights into how humans and machines localize, recognize, interpret and produce auditory events, and advance frontier technologies, e.g., automatic speech recognition, hearing prostheses, auditory monitoring/warning systems.Read moreRead less
Using written language to probe speech recognition models. Speech recognition models fall into two principal classes, with fundamentally different processing architectures. Feedback models (e.g. TRACE, McClelland & Elman, 1986) allow lexical knowledge to exert top-down control over phonemic analysis. Feedforward models (e.g. Merge, Norris, McQueen & Cutler, 2000) assume that information flow is entirely bottom-up. Our project adopts an innovative approach to testing between these model classe ....Using written language to probe speech recognition models. Speech recognition models fall into two principal classes, with fundamentally different processing architectures. Feedback models (e.g. TRACE, McClelland & Elman, 1986) allow lexical knowledge to exert top-down control over phonemic analysis. Feedforward models (e.g. Merge, Norris, McQueen & Cutler, 2000) assume that information flow is entirely bottom-up. Our project adopts an innovative approach to testing between these model classes, by examining the influence of written-word knowledge on speech perception. To distinguish the models, contrasts must test different processing levels and examine strategy effects. TRACE favors broad effects with limited strategic influence; Merge favors lexical effects that are necessarily sensitive to strategic factorsRead moreRead less
Reconciling perceptual and cognitive accounts of dyslexia: The neural rate deficit hypothesis. The proposed research will form part of a co-ordinated program to understand the causes of dyslexia, a disorder that affects a large number of children and often persists into adulthood. It complements parallel efforts to elucidate the genetic basis of dyslexia, the heterogeneity and subtypes of dyslexia, and the developmental precursors to the disorder. This research will inform early intervention and ....Reconciling perceptual and cognitive accounts of dyslexia: The neural rate deficit hypothesis. The proposed research will form part of a co-ordinated program to understand the causes of dyslexia, a disorder that affects a large number of children and often persists into adulthood. It complements parallel efforts to elucidate the genetic basis of dyslexia, the heterogeneity and subtypes of dyslexia, and the developmental precursors to the disorder. This research will inform early intervention and remediation efforts and will also assist in the understanding of the normal process of reading acquisition in children.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882345
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
A 3.0 Tesla MRI system for human cognitive neuroscience research. For the first time scientists are beginning to reveal the complex relationship between human brain function and behaviour. These advances have stemmed almost exclusively from the development of sophisticated brain scanning techniques that provide high-resolution images of physiological changes associated with perceptual, cognitive and motor behaviours. This application seeks support for a state-of-the-art scanner to obtain high-re ....A 3.0 Tesla MRI system for human cognitive neuroscience research. For the first time scientists are beginning to reveal the complex relationship between human brain function and behaviour. These advances have stemmed almost exclusively from the development of sophisticated brain scanning techniques that provide high-resolution images of physiological changes associated with perceptual, cognitive and motor behaviours. This application seeks support for a state-of-the-art scanner to obtain high-resolution images of the brain as healthy adults perceive, think, learn, remember and decide. The facility will enable Australian scientists to understand the complex links between brain and behaviour in health and disease.Read moreRead less