Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and ....Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and molecular analytes. By performing research to further understand and develop this tuneable effect, this project aims to build and test a new platform technology to enable highly efficient capture and specific detection of low concentration pathogenic molecules and circulating tumour cells (CTCs).Read moreRead less
Self-assembled phases as effective and selective materials for analysis. This project aims to develop a suite of self-assembled amphiphilic molecules to form distinctive materials for analytical chemistry. The cost-effective, easy to prepare, selective and environmentally benign materials will be for non-volatile bioactive and chiral molecular targets that are commonly encountered every day or are difficult to study. The project will open a new research area and will further uplift the internati ....Self-assembled phases as effective and selective materials for analysis. This project aims to develop a suite of self-assembled amphiphilic molecules to form distinctive materials for analytical chemistry. The cost-effective, easy to prepare, selective and environmentally benign materials will be for non-volatile bioactive and chiral molecular targets that are commonly encountered every day or are difficult to study. The project will open a new research area and will further uplift the international standing of Australia in the field. The project will provide a high level of training and expertise for Australia-based chemists.Read moreRead less
Improving eyewitness identification accuracy using free-report lineups. There is major national and community interest in the successful conduct of criminal investigations. This research addresses the accuracy of eyewitness identification tests. Specifically, we investigate whether developing lineup procedures that separate out witnesses who are unsure of their response will prevent erroneous identifications. Progress on this issue makes an important contribution to decisions about the ideal lin ....Improving eyewitness identification accuracy using free-report lineups. There is major national and community interest in the successful conduct of criminal investigations. This research addresses the accuracy of eyewitness identification tests. Specifically, we investigate whether developing lineup procedures that separate out witnesses who are unsure of their response will prevent erroneous identifications. Progress on this issue makes an important contribution to decisions about the ideal lineup procedure, thereby preventing innocent people from being prosecuted and perpetrators being free to re-offend. Additionally the international collaboration on the project will increase the visibility of Australian social science research and provide crucial development opportunities for young Australian scientists.Read moreRead less
Identifying the bad guy with deadlined confidence judgments. There is major interest in the successful conduct of criminal investigations. Identity tests are commonly used in such investigations, but eyewitness decision accuracy is still unacceptably low. While eyewitness memory research has already contributed significantly to the development of procedures that improve the diagnosticity of identification decisions, our proposal offers radical new alternatives that can significantly improve diag ....Identifying the bad guy with deadlined confidence judgments. There is major interest in the successful conduct of criminal investigations. Identity tests are commonly used in such investigations, but eyewitness decision accuracy is still unacceptably low. While eyewitness memory research has already contributed significantly to the development of procedures that improve the diagnosticity of identification decisions, our proposal offers radical new alternatives that can significantly improve diagnosticity. In refining and evaluating these alternatives we will boost the profile of Australian science research and provide rich international training environments for young Australian and overseas scientists.Read moreRead less
Proteomics of the Influenza Virus for In-field Surveillance. The influenza virus continues to pose a serious health risk to Australians and remains a leading cause of death. The molecular characterisation of emerging strains of the virus lies at the heart of current surveillance procedures vital to vaccine preparation and the development of new anti-viral drugs. This research will advance a world-first proteomics surveillance of the virus developed in this laboratory that will enable it to be ch ....Proteomics of the Influenza Virus for In-field Surveillance. The influenza virus continues to pose a serious health risk to Australians and remains a leading cause of death. The molecular characterisation of emerging strains of the virus lies at the heart of current surveillance procedures vital to vaccine preparation and the development of new anti-viral drugs. This research will advance a world-first proteomics surveillance of the virus developed in this laboratory that will enable it to be characterised in-field at the site(s) of infection outbreaks. This rapid response is vital, particularly in the event of a pandemic or a deliberate release of the virus in a bioterrorist attack.Read moreRead less
Noncanonical epitope recognition by CD8+ T lymphocytes. This proposed research program will provide significant fundamental insight in the areas of immunology and vaccine design. Vaccines for many diseases remain elusive, and this project aims to improve our understanding of the precise regions within pathogens that are the targets for the killer T cells of the immune system. These regions, called epitopes, are likely to be key ingredients in many future vaccines. Although immunologists have gat ....Noncanonical epitope recognition by CD8+ T lymphocytes. This proposed research program will provide significant fundamental insight in the areas of immunology and vaccine design. Vaccines for many diseases remain elusive, and this project aims to improve our understanding of the precise regions within pathogens that are the targets for the killer T cells of the immune system. These regions, called epitopes, are likely to be key ingredients in many future vaccines. Although immunologists have gathered much information about such epitopes, recent studies have shown that some unexpected regions of pathogens are targets for killer T cells. This project will break new ground by utilising unbiased procedures to assess the relative contribution of these noncanonical epitopes to immunity.Read moreRead less
'As-if thinking': an experimental analysis of human reasoning and decision-making. The failure to respond adequately to the havoc wreaked by Hurricane Katrina in 2005 highlighted the difficulty of sequential decision-making. Responses to such emergencies require detailed contingency plans, necessitating a consideration of all possible outcomes of a situation regardless of their objective probability. This project takes an innovative approach to the experimental analysis of human reasoning and de ....'As-if thinking': an experimental analysis of human reasoning and decision-making. The failure to respond adequately to the havoc wreaked by Hurricane Katrina in 2005 highlighted the difficulty of sequential decision-making. Responses to such emergencies require detailed contingency plans, necessitating a consideration of all possible outcomes of a situation regardless of their objective probability. This project takes an innovative approach to the experimental analysis of human reasoning and decision-making, with the aim of identifying the mechanisms, factors, and boundary conditions affecting inferences and decisions about uncertain alternatives. The research will inform planning for Australia's readiness to respond to unpredictable events with uncertain outcomes and enhance the reputation of Australian science.Read moreRead less
Associability processes in propositional learning. A novel attentional model of learning is evaluated in this project. In this model, learning is seen not as a consequence of a low-level, evolutionarily old system shared with our ancestors, but as a product of our capacity to apply rules and engage in reasoning. Understanding the role of attention in learning will allow a better understanding of the attentional biases seen in clinical disorders such as addiction and a new way to think about the ....Associability processes in propositional learning. A novel attentional model of learning is evaluated in this project. In this model, learning is seen not as a consequence of a low-level, evolutionarily old system shared with our ancestors, but as a product of our capacity to apply rules and engage in reasoning. Understanding the role of attention in learning will allow a better understanding of the attentional biases seen in clinical disorders such as addiction and a new way to think about the neuroscience of attention. These benefits may further suggest new lines of research in the development of drugs to combat attentional disorders.Read moreRead less
A new theory of visual word recognition and reading aloud. The results of this research will lead to an improvement in the theory of reading, which will in turn improve the quality of advice to speech pathologists, teachers, parents and the broader community about children’s reading difficulties and their treatment.
The Control of Memory Access. The topic of control processes in memory access is central to most of the big questions about human memory such as; why we forget, what produces spectacular and tragic memory failures (e.g.,lighting a match to check the level of petrol in a tank) and the role of context in familiarity and recollection. Because of the centrality of the problems addressed there will be many applications for the results. The long term results will include better models for human ope ....The Control of Memory Access. The topic of control processes in memory access is central to most of the big questions about human memory such as; why we forget, what produces spectacular and tragic memory failures (e.g.,lighting a match to check the level of petrol in a tank) and the role of context in familiarity and recollection. Because of the centrality of the problems addressed there will be many applications for the results. The long term results will include better models for human operators which can be used in both civilian (e.g., air traffic control) and military applications. Other areas of application will include how we measure memory impairment, why we make errors in industrial settings, and the nature of memory deficits as we age. Read moreRead less