Diseases caused by the pneumococcus represent the largest cause of vaccine preventable death in the world today, mainly pneumonia and meningitis. In 2011, 16 developing countries will introduce pneumococcal conjugate vaccines, none in east Asia. Lack of research has been a major barrier to their use in the region. We have established an international centre of excellence in the field and we seek support to extend the capacity of this group and to transfer the technology to Vietnam.
Unravelling The Mechanism Of MHC Class-I Associated Drug Hypersensitivities
Funder
National Health and Medical Research Council
Funding Amount
$566,308.00
Summary
Some drugs cause adverse reactions that are life threatening. We think these reactions are mediated by killer T cells as they are genetically controlled by immune response genes that normally guide immunity to microbes. We will study immune reactions to the drug abacavir, used to treat HIV (AIDS); allopurinol used to prevent gout and carbamazepine, used to treat epilepsy. The study may also help devise better treatments for patients who experience severe forms of these reactions.
Impact Of DTP Schedules On The Immunogenicity Of 2 Doses Of 13v-PCV Followed By An Early Booster
Funder
National Health and Medical Research Council
Funding Amount
$2,651,687.00
Summary
This project aims to come up with a vaccination schedule to make pneumococcal vaccines more effective and affordable for Fiji and other developing countries. We will evaluate schedules involving a 2 dose primary series in early infancy with a booster at 9 months of age. We will compare the immune responses to 3 different primary series and 2 booster options. The results of this project will be used to provide advice, at global and country levels, regarding introduction of pneumococcal vaccines.
Optimising disease surveillance to support decision-making. COVID-19 has demonstrated the critical role of epidemic data and analytics in guiding government response to pandemic threats, reducing disease and saving lives. The demand for epidemic analytics for response to threats of national significance will only grow. The goals of this project are to 1) determine the combination(s) of surveillance methods that provide the most useful data for epidemic analysis and 2) translate these findings in ....Optimising disease surveillance to support decision-making. COVID-19 has demonstrated the critical role of epidemic data and analytics in guiding government response to pandemic threats, reducing disease and saving lives. The demand for epidemic analytics for response to threats of national significance will only grow. The goals of this project are to 1) determine the combination(s) of surveillance methods that provide the most useful data for epidemic analysis and 2) translate these findings into the blueprint for a next-generation infectious disease surveillance system for Australia. We will use a simulation-evaluation approach, coupling methods from infectious disease modelling with those from information theory optimal design. Outcomes will enable more tailored and effective pandemic response.Read moreRead less
Food allergies have emerged as a major public health concern affecting 1 in 10 Australian infants. Hospitals waiting times are in excess of 12-months for specialist services. Recent changes in the environment are driving up rates of food allergy but the mechanisms are unclear. Epigenetics is the science of how the environment influences gene behaviour. This fellowship will address the important and urgent question of how modern environments are changing our genes, leading to food allergy.
Integrating Models of Memory for Serial Order. This research aims to compare and integrate computational models of memory for serial order. The applicants have independently developed theoretically novel models, and this collaboration will enable them to combine and strengthen their complementary perspectives.
Much psychologically important processing, for example speech perception and spelling, requires the representation and reproduction of serial order information. Existing models account ....Integrating Models of Memory for Serial Order. This research aims to compare and integrate computational models of memory for serial order. The applicants have independently developed theoretically novel models, and this collaboration will enable them to combine and strengthen their complementary perspectives.
Much psychologically important processing, for example speech perception and spelling, requires the representation and reproduction of serial order information. Existing models account for a wide range of data and collectively represent exciting progress in the understanding of basic mechanisms of memory. Can these models be unified and reconciled? To date, detailed comparisons of models are lacking. This proposal is for the applicants to elaborate and unify their contrasting theoretical approaches.
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The role of time and similarity in short-term memory. The project examines the role of time and similarity in memory for serial order, with the long-term goal to construct a new computational model of short-term memory. The investigators are internationally known for their models, and the collaboration will enable them to combine their complementary perspectives into a unifying theory. Theory construction will be guided by two sets of studies: The first will delineate the circumstances, if any, ....The role of time and similarity in short-term memory. The project examines the role of time and similarity in memory for serial order, with the long-term goal to construct a new computational model of short-term memory. The investigators are internationally known for their models, and the collaboration will enable them to combine their complementary perspectives into a unifying theory. Theory construction will be guided by two sets of studies: The first will delineate the circumstances, if any, under which temporal separation at encoding affects memory. So far, we have shown that temporal distinctiveness has no effect on memory, unless people use temporal gaps to 'chunk' the list. The second set of studies will examine whether phonological similarity determines the strength of encoding.Read moreRead less
Uncovering the processes underlying human category learning. There is a pervasive belief that complex tasks can somehow be learned via a 'smart' implicit or procedural learning mechanism, which operates independently of memory and attention. This idea has important implications for our understanding of cognition. If true, there seems little point in providing explicit instruction in such tasks, and efforts to do so are, at best, wasted time and, at worst, detrimental to the learning process. Th ....Uncovering the processes underlying human category learning. There is a pervasive belief that complex tasks can somehow be learned via a 'smart' implicit or procedural learning mechanism, which operates independently of memory and attention. This idea has important implications for our understanding of cognition. If true, there seems little point in providing explicit instruction in such tasks, and efforts to do so are, at best, wasted time and, at worst, detrimental to the learning process. This project will provide much-needed scrutiny of this idea and will help not only to re-orient our understanding of how we deal with complex information, but will also highlight issues about data interpretation that are fundamental for the research and wider communities.Read moreRead less
Binding in working memory. Cross-modal binding?the integration of verbal and spatial features of events?is central to human cognition. However, it has been neglected in the study of working memory, where the dominant theoretical framework includes separate subsystems for the retention of verbal and spatial information. Using novel paradigms involving the concurrent auditory presentation of verbal and spatial information, the proposed research is directed at discovering (1) the fundamental chara ....Binding in working memory. Cross-modal binding?the integration of verbal and spatial features of events?is central to human cognition. However, it has been neglected in the study of working memory, where the dominant theoretical framework includes separate subsystems for the retention of verbal and spatial information. Using novel paradigms involving the concurrent auditory presentation of verbal and spatial information, the proposed research is directed at discovering (1) the fundamental characteristics of binding, and (2) the extent to which benchmark effects previously identified with a particular modality are ?inherited? by the other modality under conditions conducive to binding. Outcomes of the research will provide important constraints on the development of theories of working memory. In addition, the research will develop paradigms that have potentially important applications to clinical psychology, where diverse forms of psychopathology have been linked to deficits in binding.Read moreRead less
Time and Updating of Memory. What could be simpler than reading a few items, such as the digits in a phone number, and recalling them in the right order a short while later? Notwithstanding its apparent simplicity, this short-term serial recall task underlies sophisticated language abilities such as vocabulary acquisition and utterance production. Similarly, serial retention can be a critical element in mental arithmetic. A better understanding of short-term memory for serial order therefore has ....Time and Updating of Memory. What could be simpler than reading a few items, such as the digits in a phone number, and recalling them in the right order a short while later? Notwithstanding its apparent simplicity, this short-term serial recall task underlies sophisticated language abilities such as vocabulary acquisition and utterance production. Similarly, serial retention can be a critical element in mental arithmetic. A better understanding of short-term memory for serial order therefore has wide implications across many areas of education, in particular in primary school settings. The community benefit of this project arises from the improved teaching methods that can be developed on the basis of these results.Read moreRead less