Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to im ....Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to improve models of future seismic hazard in Australia and globally. This will lead to improved predictions of future earthquake impacts in urban and natural environments and development of new paleoseismic techniques.Read moreRead less
A unified approach for estimating coastal flood risk. The project aims to develop a unified approach to quantifying flood risk. Because flooding is caused by multiple mechanisms such as extreme rainfall, storm surge and astronomical tide, accurately estimating flood levels in the Australian coastal zone is challenging. By quantifying flood risk in terms of these mechanisms, the project is expected to provide reliable flood risk estimates for both historical settings and future climate scenarios. ....A unified approach for estimating coastal flood risk. The project aims to develop a unified approach to quantifying flood risk. Because flooding is caused by multiple mechanisms such as extreme rainfall, storm surge and astronomical tide, accurately estimating flood levels in the Australian coastal zone is challenging. By quantifying flood risk in terms of these mechanisms, the project is expected to provide reliable flood risk estimates for both historical settings and future climate scenarios. The improved estimation should enable Australian water agencies and policy-makers to effectively design defence infrastructure (e.g. drainage systems) and urban planning policies to adapt to future flood risk.Read moreRead less
The Impact Of The Neonatal Gut Microbiome On Specific And Nonspecific Vaccine Responses.
Funder
National Health and Medical Research Council
Funding Amount
$661,496.00
Summary
Humans are colonised by a large and diverse group of microorganisms, collectively known as the microbiome. The gut microbiome, in particular, hosts an enormous abundance and diversity of bacteria, which perform a range of essential beneficial functions. Our study will investigate whether disruption of the gut microbiome in newborns, for example through antibiotic usage or maternal diet, leads to an impairment of subsequent immune responses to childhood immunisations.
The development of vaccines and better treatments for HIV-AIDS and Hepatitis C are urgent global health priorities. This Program will undertake studies to better understand effective immunity against HIV and hepatitis C, allowing the rational design and testing of novel vaccines and treatments. The Program brings together a team of researchers with skills in basic virology and immunology with those providing expertise in translating findings in the laboratory into human clinical trials.
Contemporary stress and tectonics of Australia. This project will conduct a detailed examination of the state and controls on present-day tectonic stress in Australia. Tectonic stresses are a primary control on deformation in the Earth and this project has direct applications for earthquake hazard assessment, mine stability, production of petroleum and geothermal energy, and carbon dioxide sequestration.
Using natural products to inspire discoveries in synthesis and biosynthesis. This project aims to understand the organic chemistry that occurs in the biosynthesis of unusual antibiotic natural products by marine microorganisms. In an interdisciplinary approach, proposed biosynthetic intermediates will be synthesised and screened against newly isolated enzymes from the microorganisms of interest. This will allow the elucidation of biosynthetic pathways, and aid the discovery of new chemoenzymatic ....Using natural products to inspire discoveries in synthesis and biosynthesis. This project aims to understand the organic chemistry that occurs in the biosynthesis of unusual antibiotic natural products by marine microorganisms. In an interdisciplinary approach, proposed biosynthetic intermediates will be synthesised and screened against newly isolated enzymes from the microorganisms of interest. This will allow the elucidation of biosynthetic pathways, and aid the discovery of new chemoenzymatic reactivity that may be broadly useful in organic synthesis. Non-enzymatic, predisposed organic reactions will also be uncovered during the project. The benefit of this project will be an improvement in our ability to synthesise potential antibiotics using a combined synthetic organic and chemoenzymatic approach. This could lead to useful new antibiotics in the future.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100689
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Applying nature's chemistry to the synthesis of complex bioactive natural products. Organic molecules come in all shapes and sizes, and the synthesis of them is crucial to industries as diverse as pharmaceuticals, electronics, cosmetics and agrochemicals. This project aims to develop new ways of making unusual and potentially useful naturally occurring organic molecules using chemistry that mimics how they are formed in nature.
Predisposed organic synthesis inspired by the simplicty of nature. The aim of this project is to use the simplicity and efficiency of biosynthesis to inspire the development of new strategies for the synthesis of whole families of related natural products with known antibiotic activity. Natural products with potent antibiotic properties are produced by microorganisms as a means of chemical defence. These complex molecules are biosynthesised from a limited set of simple biosynthetic building bloc ....Predisposed organic synthesis inspired by the simplicty of nature. The aim of this project is to use the simplicity and efficiency of biosynthesis to inspire the development of new strategies for the synthesis of whole families of related natural products with known antibiotic activity. Natural products with potent antibiotic properties are produced by microorganisms as a means of chemical defence. These complex molecules are biosynthesised from a limited set of simple biosynthetic building blocks via predisposed, complexity generating cascade reactions. The project aims to generate new lead compounds for the advancement of next-generation antibiotics. The synthesis of proposed biosynthetic intermediates would also allow enzymatic studies to help confirm the novel biosynthetic proposals.Read moreRead less
I am a molecular virologist researching the host response to hepatitis C virus (HCV) infection with the aim of understanding how the liver clears HCV infection. An understanding of this process will hopefully lead to novel antiviral strategies to combat not only HCV but a broad range of other viral infections.