Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
Mega spatial-scale, multi time-scale, ensemble assessment of climate change driven coastal change in South Eastern Australia. Climate change driven variations in mean sea level, storm surges, and waves will change the world's coastline. This project will, for the first time, develop innovative modelling methods to quantify the integrated impact of these climate drivers on coastal erosion along Australia's most developed and populated coastline: Sydney to Brisbane.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Special Research Initiatives - Grant ID: SR0354516
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Interdisciplinary Research Network on Property Rights in Natural Resource Management. Property rights are increasingly important in resource management, for titleholders and for the long-term viability of ecological resources. Property rights are historically and traditionally embedded in cultural practices and attitudes influencing the access, use and management of natural resources, ecosystem services and cultural assets. Understanding the history and future of property systems across social-e ....Interdisciplinary Research Network on Property Rights in Natural Resource Management. Property rights are increasingly important in resource management, for titleholders and for the long-term viability of ecological resources. Property rights are historically and traditionally embedded in cultural practices and attitudes influencing the access, use and management of natural resources, ecosystem services and cultural assets. Understanding the history and future of property systems across social-ecological landscapes is fragmented across disciplines, including natural sciences, social sciences and humanities. The interdisciplinary network on property rights in resource management will draw together researchers, building new synergies, novel research agendas and solutions for end users including property owners, resource managers, policy makers, planners and valuers.Read moreRead less
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
The big flood: will it happen again? If we could better predict the frequency of extreme flood events, would we be better prepared to safeguard human lives and settlements? This project provides a time-line of flood activity in the south east Queensland region extending back thousands of years using state-of-the-art dating techniques and seeks to identifiy those settlements most at risk.
Quantifying the El Niño-Indian Ocean Dipole system using high-resolution coral palaeoclimate archives. The ocean surrounding Indonesia is the warmest on Earth and a major source of energy for global atmospheric circulation. Understanding the role of the Warm Pool in future climate change is of key importance, but highly controversial because the potential extent of its variability is largely unknown. To address this issue, this project will provide the first major geochemical investigation of ....Quantifying the El Niño-Indian Ocean Dipole system using high-resolution coral palaeoclimate archives. The ocean surrounding Indonesia is the warmest on Earth and a major source of energy for global atmospheric circulation. Understanding the role of the Warm Pool in future climate change is of key importance, but highly controversial because the potential extent of its variability is largely unknown. To address this issue, this project will provide the first major geochemical investigation of recently discovered ancient corals in Indonesia using state-of-the-art microanalytical techniques. Outcomes from these palaeoclimate records will advance our understanding of global climate change, rainfall variability related to the El Nino - Indian Ocean Dipole system, and Australian drought.Read moreRead less
Inhibition Of Interferon-?/? Induction By Ross River Virus
Funder
National Health and Medical Research Council
Funding Amount
$589,664.00
Summary
Ross River virus is a mosquito-borne virus that causes arthritis in the joints of many people infected. This project will look at the early interactions of a virulent virus with the mammalian host that appear to enable the virus to replicate and spread in the host and thereby cause disease. These interactions are with the host interferon protein which the virus has developed the ability to inhibit. The effect of the invading virus on the host's interferon system, part of the immune system, will ....Ross River virus is a mosquito-borne virus that causes arthritis in the joints of many people infected. This project will look at the early interactions of a virulent virus with the mammalian host that appear to enable the virus to replicate and spread in the host and thereby cause disease. These interactions are with the host interferon protein which the virus has developed the ability to inhibit. The effect of the invading virus on the host's interferon system, part of the immune system, will be examined.Read moreRead less
Intellectual property and climate change: inventing clean technologies. By providing recommendations about intellectual property law, policy and practice to policy-makers and stakeholders, this project will promote research and development of clean technologies in Australia. It will also facilitate the transfer of such technologies in Australia and to developing countries and least developed countries.
Special Research Initiatives - Grant ID: SR0354575
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Earth and Ocean Informatics and Technology Network (EON-ITnet). Sustainable resource exploration and mining onshore, as well as marine planning, exploration, and defence depend on effective cross-disciplinary investigation, sharing of expertise and technologies for integration and computational analysis of multidimensional data spaces. EON-ITNET will cross-fertilise the use of artificial intelligence, advanced computing and smart information sharing for management, analysis, visualisation and me ....Earth and Ocean Informatics and Technology Network (EON-ITnet). Sustainable resource exploration and mining onshore, as well as marine planning, exploration, and defence depend on effective cross-disciplinary investigation, sharing of expertise and technologies for integration and computational analysis of multidimensional data spaces. EON-ITNET will cross-fertilise the use of artificial intelligence, advanced computing and smart information sharing for management, analysis, visualisation and metadata modelling between these traditionally separate research groups, with the outcome of improving research efficiency and lowering costs. EON-ITNET will form an alliance with the Caltech-based GeoFramework, which is advancing a novel object-oriented data analysis environment, binding community software for Earth visualisation and simulation to 4D data bases.Read moreRead less