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Mega spatial-scale, multi time-scale, ensemble assessment of climate change driven coastal change in South Eastern Australia. Climate change driven variations in mean sea level, storm surges, and waves will change the world's coastline. This project will, for the first time, develop innovative modelling methods to quantify the integrated impact of these climate drivers on coastal erosion along Australia's most developed and populated coastline: Sydney to Brisbane.
Intellectual property and climate change: inventing clean technologies. By providing recommendations about intellectual property law, policy and practice to policy-makers and stakeholders, this project will promote research and development of clean technologies in Australia. It will also facilitate the transfer of such technologies in Australia and to developing countries and least developed countries.
New Frontiers in Innate Immunity. This program aims to define how the immune system senses and responds to environmental cues. By combining interdisciplinary approaches with cutting-edge imaging and spatial biology technologies, this program expects to reveal how immune sensor proteins are regulated at the molecular, cellular and tissue level. Outcomes of this program include unparalleled insights into molecular mechanisms that underpin effective functioning of the immune system, training of fut ....New Frontiers in Innate Immunity. This program aims to define how the immune system senses and responds to environmental cues. By combining interdisciplinary approaches with cutting-edge imaging and spatial biology technologies, this program expects to reveal how immune sensor proteins are regulated at the molecular, cellular and tissue level. Outcomes of this program include unparalleled insights into molecular mechanisms that underpin effective functioning of the immune system, training of future scientists, and strengthening international collaborations across academia and industry. This will contribute to a high-quality workforce for research and innovation, and secure Australia’s position at the forefront of immunology research driven by cutting-edge technologies. Read moreRead less
Toll-like receptors in infectious and inflammatory diseases: the double-edged sword of innate immunity. The innate immune system is the first line of defence against invading microorganisms. This project will explore the role of specific innate immune genes in the control of infections and the development of inflammatory diseases.
Inflammasomes: molecular drivers of anti-microbial defence. The innate immune system is the body’s first line of defence against infection, but also drives unhealthy inflammation. Families of innate immune receptors, such as nucleotide-binding oligomerisation domain (NOD-like Receptors), were recently discovered to control both anti-microbial defence and unhealthy inflammation. This project will characterise the basic biology of NOD-like Receptors at the molecular, cellular and organismal levels ....Inflammasomes: molecular drivers of anti-microbial defence. The innate immune system is the body’s first line of defence against infection, but also drives unhealthy inflammation. Families of innate immune receptors, such as nucleotide-binding oligomerisation domain (NOD-like Receptors), were recently discovered to control both anti-microbial defence and unhealthy inflammation. This project will characterise the basic biology of NOD-like Receptors at the molecular, cellular and organismal levels, and will thereby lead to a greater understanding of the fundamental biological pathways controlling inflammation and defence against infection. This may ultimately lead to commercial opportunities for treating infection and chronic inflammation.Read moreRead less
Better water management through more focus on ecological and social sciences. Current water resources management, focusing on gains of economic efficiency in the short term under the assumption of steady-state conditions, has generally failed to respond to both catchment environmental degradation and to the increasing complexity of human–environment interactions. This project will develop a new approach to water resources management by relating management practices based on ecological understand ....Better water management through more focus on ecological and social sciences. Current water resources management, focusing on gains of economic efficiency in the short term under the assumption of steady-state conditions, has generally failed to respond to both catchment environmental degradation and to the increasing complexity of human–environment interactions. This project will develop a new approach to water resources management by relating management practices based on ecological understanding to the social mechanisms behind these practices at water catchments. It will improve the predictability and precision of water resources management and increase our ability to maintain our options for a sustainable future. This will have a profound effect on catchment sustainability, a globally significant problem.Read moreRead less
Towards the sustainable discovery and development of new antibiotics. This project aims to define how to access silent biosynthetic genes within microbial genome to facilitate access to new chemical diversity hidden within microbial genomes. Using interdisciplinary approaches in genome mining and metabolomics technologies, the project expects to inspire and enable the future design of more effective antibiotics. Expected outcomes from this program include define new microbial defence molecules, ....Towards the sustainable discovery and development of new antibiotics. This project aims to define how to access silent biosynthetic genes within microbial genome to facilitate access to new chemical diversity hidden within microbial genomes. Using interdisciplinary approaches in genome mining and metabolomics technologies, the project expects to inspire and enable the future design of more effective antibiotics. Expected outcomes from this program include define new microbial defence molecules, to meet future demands in agrochemical and environmental sciences. It will also train future scientists and develop international collaborations. This should provide significant benefit, including a higher-quality workforce for research and innovation, positioning Australia at the forefront of drug discovery. Read moreRead less
Investigating the role of the innate immune complement system in the abnormal development of the central nervous system. Past research has discovered a surprising link between the immune system, dietary folate deficiency and the development of the embryonic brain. This project will investigate the immune system in the developing brain, in order to understand the causes of developmental defects such as neural tube defects, and the role dietary folate plays in this process.
Integrating the conservation and ecosystem-service value of Australia's catchments. This project addresses the Priority Goal of Sustainable Use of Biodiversity by explicitly linking the intrinsic value of biodiversity and supporting ecosystems with the services they provide to humanity (e.g. carbon storage and nutrient cycling). It will employ a comprehensive, innovative approach to integrating conservation, market and non-market values of land holdings in Australia's catchments using the concep ....Integrating the conservation and ecosystem-service value of Australia's catchments. This project addresses the Priority Goal of Sustainable Use of Biodiversity by explicitly linking the intrinsic value of biodiversity and supporting ecosystems with the services they provide to humanity (e.g. carbon storage and nutrient cycling). It will employ a comprehensive, innovative approach to integrating conservation, market and non-market values of land holdings in Australia's catchments using the concept of nature's services. Through extensive collaboration among leading scientists and land managers, the project will identify sites of high value requiring special attention, yield important theoretical advancements to how we value ecosystems, and provide practical and easily applied guidelines for land managers. Read moreRead less
Impaired innate antiviral immunity predisposes toward virus-associated airway remodelling in childhood asthma. Increased airway smooth muscle (ASM) mass is the major pathological feature of asthma that causes poor lung function. ASM remodelling occurs in early life, is refractory to current treatments and persists into later life. Severe respiratory virus infections in early life are a major risk factor for the development of asthma, yet it remains to be determined whether viruses promote ASM re ....Impaired innate antiviral immunity predisposes toward virus-associated airway remodelling in childhood asthma. Increased airway smooth muscle (ASM) mass is the major pathological feature of asthma that causes poor lung function. ASM remodelling occurs in early life, is refractory to current treatments and persists into later life. Severe respiratory virus infections in early life are a major risk factor for the development of asthma, yet it remains to be determined whether viruses promote ASM remodelling. Previous studies have developed a unique mouse model of childhood asthma and discovered the molecular mechanism by which this tissue tropism develops in response to virus infection. This project will identify new targets for immunomodulation and design new biologics to block ASM remodelling and the deleterious effects of respiratory virus infection in asthmatic subjects. Read moreRead less