The Role Of Novel G-Protein Coupled Receptors In Immunity And Inflammatory Diseases
Funder
National Health and Medical Research Council
Funding Amount
$69,684.00
Summary
Recent advances in molecular biology techniques have resulted in the identification of many novel GPCRs. Novel GPCRs expressed selectively on immune cells display a potential target for novel therapies for inflammatory diseases such as Asthma and Rheumatoid arthritis. This project aims to define the activity and significance of a novel group of GPCRs, the GPR40 family. Outcomes of this project will be further understanding of immune cell development and inflammatory disease development.
The Interplay Between Viperin, Peroxisomes And The Cellular Innate Antiviral Response
Funder
National Health and Medical Research Council
Funding Amount
$556,127.00
Summary
Infection with a virus initiates a cellular antiviral response that attempts to limit viral replication, however how this response is regulated is not well understood. In this proposal we will investigate a cellular protein (viperin) that can regulate this process by interaction with peroxisomes to amplify the antiviral response. This work will provide possible targets for therapeutic manipulation of the innate immune response that will be applicable to a wide range of viral infections.
Fragmentation of rocks upon impact. The project aims to create a new understanding of how rocks fragment upon impact to allow more realistic predictions of rockfall hazards. Rockfall results in loss of human life, damage to infrastructure and economic loss; each year in Australia, millions of dollars are spent on rockfall protection. To mitigate rockfall risk, it is important to understand and predict how blocks break as they fall down a slope. Unfortunately, there is limited data and knowledge ....Fragmentation of rocks upon impact. The project aims to create a new understanding of how rocks fragment upon impact to allow more realistic predictions of rockfall hazards. Rockfall results in loss of human life, damage to infrastructure and economic loss; each year in Australia, millions of dollars are spent on rockfall protection. To mitigate rockfall risk, it is important to understand and predict how blocks break as they fall down a slope. Unfortunately, there is limited data and knowledge on this phenomenon. This project aims to produce a comprehensive, high-quality database of fragmentation events and develop an innovative fragmentation model that can be included in existing rockfall codes. This project is expected to lead to optimised and cost-effective rockfall barrier protection measures.Read moreRead less
Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to im ....Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to improve models of future seismic hazard in Australia and globally. This will lead to improved predictions of future earthquake impacts in urban and natural environments and development of new paleoseismic techniques.Read moreRead less
An Australian storm wave damage and beach erosion early warning system. This project aims to develop a new coastal hazard early-warning system capability for Australia, to alert coastal communities, emergency managers and coastal engineers to impending storm wave damage and coastal erosion. Emergency preparedness informed by early warning is expected to significantly benefit vulnerable communities and infrastructure along Australia’s coasts.
Fish Jenga: metapopulation management for coastal river fish. This project aims to address the escalating threats to coastal freshwater fish from drought, fire, and other disturbances. The project expects to generate new knowledge on contemporary distributions of NSW coastal freshwater fishes, and will develop models of population dynamics to explore the consequences of alternative water management and disturbance scenarios. The expected outcome of the project is to revolutionise management by r ....Fish Jenga: metapopulation management for coastal river fish. This project aims to address the escalating threats to coastal freshwater fish from drought, fire, and other disturbances. The project expects to generate new knowledge on contemporary distributions of NSW coastal freshwater fishes, and will develop models of population dynamics to explore the consequences of alternative water management and disturbance scenarios. The expected outcome of the project is to revolutionise management by replacing the current practice of managing river basins separately, with a framework that accounts for among-basin linkages that are essential for the long-term persistence of fish populations. Significant benefits include more efficient use of water resources and improved conservation outcomes for native fish.Read moreRead less
The effective strength of oceanic plate bounding faults. This project will address the anomalously weak behaviour of the seismically active faults on the boundary of the Australian plate, in three key geodynamic areas. This will constrain the mechanisms which weaken such faults, and produce a model for their effective strength and evolution over geological timescales.
Investigation of atypical bushfire spread driven by the interaction of wind, terrain and fire. Large bushfires continue to pose a significant risk to communities in south-eastern Australia. Despite this, there is still very little known about the processes driving the development of large bushfires. This project aims to improve understanding of extreme fire processes and thus improve mitigation planning, community safety and environmental outcomes.
Shaping a sunburnt country: fire, climate and the Australian landscape. Fire shapes Australia’s landscape, biodiversity and resources. This project aims to quantify the recent history of fire intensity and severity using several novel proxies in the fire-prone landscapes of south-eastern Australia. Calibration of these new proxies to recent wildfires will be used for a better characterisation of fire regimes. This research will be applied to sedimentary archives to investigate how fire regimes h ....Shaping a sunburnt country: fire, climate and the Australian landscape. Fire shapes Australia’s landscape, biodiversity and resources. This project aims to quantify the recent history of fire intensity and severity using several novel proxies in the fire-prone landscapes of south-eastern Australia. Calibration of these new proxies to recent wildfires will be used for a better characterisation of fire regimes. This research will be applied to sedimentary archives to investigate how fire regimes have evolved over the past 100 years. The outcomes will inform debates about the relationship between climatic variability and fire severity, and this will contribute to increase the preparedness of natural resource management to potential future climate and land-use scenarios.Read moreRead less