The Role Of Novel G-Protein Coupled Receptors In Immunity And Inflammatory Diseases
Funder
National Health and Medical Research Council
Funding Amount
$69,684.00
Summary
Recent advances in molecular biology techniques have resulted in the identification of many novel GPCRs. Novel GPCRs expressed selectively on immune cells display a potential target for novel therapies for inflammatory diseases such as Asthma and Rheumatoid arthritis. This project aims to define the activity and significance of a novel group of GPCRs, the GPR40 family. Outcomes of this project will be further understanding of immune cell development and inflammatory disease development.
The Interplay Between Viperin, Peroxisomes And The Cellular Innate Antiviral Response
Funder
National Health and Medical Research Council
Funding Amount
$556,127.00
Summary
Infection with a virus initiates a cellular antiviral response that attempts to limit viral replication, however how this response is regulated is not well understood. In this proposal we will investigate a cellular protein (viperin) that can regulate this process by interaction with peroxisomes to amplify the antiviral response. This work will provide possible targets for therapeutic manipulation of the innate immune response that will be applicable to a wide range of viral infections.
Fragmentation of rocks upon impact. The project aims to create a new understanding of how rocks fragment upon impact to allow more realistic predictions of rockfall hazards. Rockfall results in loss of human life, damage to infrastructure and economic loss; each year in Australia, millions of dollars are spent on rockfall protection. To mitigate rockfall risk, it is important to understand and predict how blocks break as they fall down a slope. Unfortunately, there is limited data and knowledge ....Fragmentation of rocks upon impact. The project aims to create a new understanding of how rocks fragment upon impact to allow more realistic predictions of rockfall hazards. Rockfall results in loss of human life, damage to infrastructure and economic loss; each year in Australia, millions of dollars are spent on rockfall protection. To mitigate rockfall risk, it is important to understand and predict how blocks break as they fall down a slope. Unfortunately, there is limited data and knowledge on this phenomenon. This project aims to produce a comprehensive, high-quality database of fragmentation events and develop an innovative fragmentation model that can be included in existing rockfall codes. This project is expected to lead to optimised and cost-effective rockfall barrier protection measures.Read moreRead less
Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to im ....Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to improve models of future seismic hazard in Australia and globally. This will lead to improved predictions of future earthquake impacts in urban and natural environments and development of new paleoseismic techniques.Read moreRead less
The effective strength of oceanic plate bounding faults. This project will address the anomalously weak behaviour of the seismically active faults on the boundary of the Australian plate, in three key geodynamic areas. This will constrain the mechanisms which weaken such faults, and produce a model for their effective strength and evolution over geological timescales.
Investigation of atypical bushfire spread driven by the interaction of wind, terrain and fire. Large bushfires continue to pose a significant risk to communities in south-eastern Australia. Despite this, there is still very little known about the processes driving the development of large bushfires. This project aims to improve understanding of extreme fire processes and thus improve mitigation planning, community safety and environmental outcomes.
Discovery Early Career Researcher Award - Grant ID: DE120100694
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Effective systems for managing intractable natural resource use conflict. This project aims to understand the role of the law as an actor in disputes over the exploration and exploitation of natural resources. It will examine how patterns of conflict over natural resources develop, advancing knowledge of dispute resolution approaches that account for the influence of legal structures and dynamics upon conflict.
The next generation rural landscape governance: the Australian dimension. The project team in collaboration with Industry and regional stakeholders will undertake innovative research to develop the next generation of natural resource governance in Australia. This project will focus on the reforms required to improve the sustainability performance of primary industries through reduced transaction costs, co-regulatory structures and stewardship.
Institutional transitions to sustainable agriculture: An inter-disciplinary analysis of a novel common-property resource governance system. Efforts to overcome the severe degradation of land resources supporting agriculture and human communities continue to be constrained by institutions and social norms. The knowledge needed for a transition to sustainable agricultural landscapes through institutional change is inadequate. A collaboration between specialists in economics, politics, sociology, ....Institutional transitions to sustainable agriculture: An inter-disciplinary analysis of a novel common-property resource governance system. Efforts to overcome the severe degradation of land resources supporting agriculture and human communities continue to be constrained by institutions and social norms. The knowledge needed for a transition to sustainable agricultural landscapes through institutional change is inadequate. A collaboration between specialists in economics, politics, sociology, ecology and soil science at the University of New England and graziers in an upper Murray-Darling subcatchment will analyse the transition to a common-property institution on this subcatchment. It will make a distinctively Australian contribution to international efforts to understand such transitions, and serve as a model for progress towards sustainability elsewhere in Australia.
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