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Using past climate extremes to guide infrastructure planning for the future. This project aims to analyse a 2000-year palaeoclimate record of single event and complex climate extremes to provide a long-term context for observed changes in climate extremes over recent decades. This project expects to generate new knowledge about long-term variability in the frequency and magnitude of climate extremes that occur on seasonal - decades time-scales. It also expects to provide information about com ....Using past climate extremes to guide infrastructure planning for the future. This project aims to analyse a 2000-year palaeoclimate record of single event and complex climate extremes to provide a long-term context for observed changes in climate extremes over recent decades. This project expects to generate new knowledge about long-term variability in the frequency and magnitude of climate extremes that occur on seasonal - decades time-scales. It also expects to provide information about complex extremes that involve multiple types of impacts (e.g. drought followed by flood, simultaneous drought and fire). Expected benefits of the project include improved understanding of climate extremes and improved risk estimates for the impacts of climate extremes on Australian government and industry infrastructure.Read moreRead less
The role of immuno-exosomes in innate immunity. This project aims to determine the role of exosomes (EV) in innate immunity. Exosomes are extracellular vesicles secreted by mammalian cells that have an important biological function in intercellular communication by transferring biologically active proteins, lipids, and RNAs to neighbouring or distant cells. Following exposure to a foreign organism, cells dynamically change the protein composition of the EV they secrete. While this data supports ....The role of immuno-exosomes in innate immunity. This project aims to determine the role of exosomes (EV) in innate immunity. Exosomes are extracellular vesicles secreted by mammalian cells that have an important biological function in intercellular communication by transferring biologically active proteins, lipids, and RNAs to neighbouring or distant cells. Following exposure to a foreign organism, cells dynamically change the protein composition of the EV they secrete. While this data supports a role for EV as key players in innate immunity, a full understanding of the biological relevance of these vesicles and how they serve as a cellular defence mechanism is lacking. This project will provide significant benefits such as addressing key questions in EV biology and providing new fundamental insights into a novel and poorly understood component of the innate immune response.Read moreRead less
Mega spatial-scale, multi time-scale, ensemble assessment of climate change driven coastal change in South Eastern Australia. Climate change driven variations in mean sea level, storm surges, and waves will change the world's coastline. This project will, for the first time, develop innovative modelling methods to quantify the integrated impact of these climate drivers on coastal erosion along Australia's most developed and populated coastline: Sydney to Brisbane.
Using natural products to inspire discoveries in synthesis and biosynthesis. This project aims to understand the organic chemistry that occurs in the biosynthesis of unusual antibiotic natural products by marine microorganisms. In an interdisciplinary approach, proposed biosynthetic intermediates will be synthesised and screened against newly isolated enzymes from the microorganisms of interest. This will allow the elucidation of biosynthetic pathways, and aid the discovery of new chemoenzymatic ....Using natural products to inspire discoveries in synthesis and biosynthesis. This project aims to understand the organic chemistry that occurs in the biosynthesis of unusual antibiotic natural products by marine microorganisms. In an interdisciplinary approach, proposed biosynthetic intermediates will be synthesised and screened against newly isolated enzymes from the microorganisms of interest. This will allow the elucidation of biosynthetic pathways, and aid the discovery of new chemoenzymatic reactivity that may be broadly useful in organic synthesis. Non-enzymatic, predisposed organic reactions will also be uncovered during the project. The benefit of this project will be an improvement in our ability to synthesise potential antibiotics using a combined synthetic organic and chemoenzymatic approach. This could lead to useful new antibiotics in the future.Read moreRead less
Extending the frontiers of organocatalysis: new reactions involving nucleophilic carbenes. High technology solutions to the problems of today and tomorrow require new materials designed for specific activities. This project will deliver new technologies for the rapid and efficient assembly of materials designed for function.
Strength and resistance along oceanic megathrust faults: implications for subduction initiation. Hjorta Trench, south of Macquarie Island, is a seismically active boundary of the Australian plate and a unique natural laboratory for study of the initiation of the processes which are currently driving Australia north at 7 millimetres per year. Sophisticated computer models will be used to understand the evolution of this oceanic megathrust system.
Intellectual property and climate change: inventing clean technologies. By providing recommendations about intellectual property law, policy and practice to policy-makers and stakeholders, this project will promote research and development of clean technologies in Australia. It will also facilitate the transfer of such technologies in Australia and to developing countries and least developed countries.
The Cenozoic tectonic evolution of East and Southeast Asia: interplay between the India-Eurasia collision and the Pacific and Sunda subduction zones. This project investigates how the Indo-Australian and Pacific tectonic plates have interacted with the Eurasian plate to form the largest continental deformation zone on Earth in East Asia, stretching from the Himalayas to Indonesia and eastern Siberia. This is important for understanding how mountain ranges form and how continents are torn apart.
Molecular Mechanisms of NOD signalling. Alterations in NOD1 and NOD2 (nucleotide-binding oligomerization domain containing 1 and 2) signalling have been implicated in various human inflammatory diseases. Therefore, a clear understanding of the molecular signalling pathways is important to gain further insights into potential drug targets for the treatment of these diseases. Using novel experimental approaches, this project aims to identify new members of the NOD signalling pathway. It will test ....Molecular Mechanisms of NOD signalling. Alterations in NOD1 and NOD2 (nucleotide-binding oligomerization domain containing 1 and 2) signalling have been implicated in various human inflammatory diseases. Therefore, a clear understanding of the molecular signalling pathways is important to gain further insights into potential drug targets for the treatment of these diseases. Using novel experimental approaches, this project aims to identify new members of the NOD signalling pathway. It will test the effect of pharmacological inhibition of established molecules such as RIPK2 or IAPs in NOD dependent models for human diseases. Outcomes of this study will be of the utmost interest for the treatment of NOD driven diseases such as Crohn's disease, Blau syndrome or asthma.Read moreRead less
New Frontiers in Innate Immunity. This program aims to define how the immune system senses and responds to environmental cues. By combining interdisciplinary approaches with cutting-edge imaging and spatial biology technologies, this program expects to reveal how immune sensor proteins are regulated at the molecular, cellular and tissue level. Outcomes of this program include unparalleled insights into molecular mechanisms that underpin effective functioning of the immune system, training of fut ....New Frontiers in Innate Immunity. This program aims to define how the immune system senses and responds to environmental cues. By combining interdisciplinary approaches with cutting-edge imaging and spatial biology technologies, this program expects to reveal how immune sensor proteins are regulated at the molecular, cellular and tissue level. Outcomes of this program include unparalleled insights into molecular mechanisms that underpin effective functioning of the immune system, training of future scientists, and strengthening international collaborations across academia and industry. This will contribute to a high-quality workforce for research and innovation, and secure Australia’s position at the forefront of immunology research driven by cutting-edge technologies. Read moreRead less