Electrical properties of human dendrites. This project aims to determine the electrical properties of dendrites in human neurons. Dendrites are the primary site of synaptic input to neurons and their electrical properties play a key role in information processing in the brain. While we know much about the electrical properties of dendrites in other species, primarily rodents, little is known about the electrical properties of human dendrites. This project aims to address this gap in knowledge fo ....Electrical properties of human dendrites. This project aims to determine the electrical properties of dendrites in human neurons. Dendrites are the primary site of synaptic input to neurons and their electrical properties play a key role in information processing in the brain. While we know much about the electrical properties of dendrites in other species, primarily rodents, little is known about the electrical properties of human dendrites. This project aims to address this gap in knowledge for the first time. The results obtained will shed light on the mechanisms the brain uses to process information, and therefore will bring us a step closer to truly understanding ourselves.Read moreRead less
Role of the superior colliculus in sensory processing. The ability of an organism to attend to, and orient towards, stimuli in the environment is critical for survival. In the mammalian brain, the principal brain region performing this function is the superior colliculus. Despite its importance, little is known about the role the superior colliculus plays in sensory perception. This project addresses this issue by leveraging revolutionary new recording techniques to determine how the superior co ....Role of the superior colliculus in sensory processing. The ability of an organism to attend to, and orient towards, stimuli in the environment is critical for survival. In the mammalian brain, the principal brain region performing this function is the superior colliculus. Despite its importance, little is known about the role the superior colliculus plays in sensory perception. This project addresses this issue by leveraging revolutionary new recording techniques to determine how the superior colliculus codes sensory information and ultimately drives behaviour. The outcomes will be of immediate benefit to scientists studying sensory processing and perceptual decision making, and will help keep Australia at the forefront of brain-inspired engineering and the neuroscience-based knowledge economy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less
Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovativ ....Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovative and broadly-applicable neuroscience methods and an understanding of receptors involved in plant growth and defense. Benefits of this project include an enhanced capacity to generate knowledge, multidisciplinary training opportunities and patentable synthetic biology technologies.Read moreRead less