Investigating the atomic structure of an immune cell inhibitory receptor. T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cel ....Investigating the atomic structure of an immune cell inhibitory receptor. T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cells, termed the Lymphocyte activation gene-3 (LAG-3). The proposal utilises a combination of cellular immunology and structural biology to gain insight into the form and function of the LAG-3 molecule. Ultimately this fundamental knowledge can be used by the biotechnology industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less
New guardians of the mucosa: Molecular characterisation of M cell biology. We aim to completely define the cellular and molecular biology of gut and lung M cells for the first time. We will elucidate how they develop, are regulated and function at a molecular level, and how M cells maintain normal gut and lung tissues and induce immune responses to protect against microbial challenges. In the future, the new insights will be essential pre-requisites for the development of mucosal-based intervent ....New guardians of the mucosa: Molecular characterisation of M cell biology. We aim to completely define the cellular and molecular biology of gut and lung M cells for the first time. We will elucidate how they develop, are regulated and function at a molecular level, and how M cells maintain normal gut and lung tissues and induce immune responses to protect against microbial challenges. In the future, the new insights will be essential pre-requisites for the development of mucosal-based interventions and vaccines that protect the gut and lung from infectious and inflammatory issues. The harnessing of effective immune responses to control such challenges, are of enormous fundamental and long-standing biological interest, and are amongst the most important areas of current scientific research.Read moreRead less
Lifespan-dependent molecular shaping of the T cell receptor repertoire. Mammals have an intricate and highly complex immune system, whose function alters throughout life. Why and how this occurs is very unclear however, yet remains a crucial question. This project aims to provide fundamental knowledge on how the human lifespan shapes specific T cell receptors and determine molecular mechanisms underlying gain-of-function and loss-of-function during immunologically distinct phases of life. This p ....Lifespan-dependent molecular shaping of the T cell receptor repertoire. Mammals have an intricate and highly complex immune system, whose function alters throughout life. Why and how this occurs is very unclear however, yet remains a crucial question. This project aims to provide fundamental knowledge on how the human lifespan shapes specific T cell receptors and determine molecular mechanisms underlying gain-of-function and loss-of-function during immunologically distinct phases of life. This project will provide analysis of multi-dimensional, high throughput datasets to identify fundamental links between the transcriptional landscape and TCR signatures across human lifespan, thus will significantly answer key immunological questions in the field.Read moreRead less
DeepHoney: Automatic Honey Data Generation for Active Cyber Defence . This project aims to enhance the security of networks and information systems by empowering them with intelligent deception techniques to achieve proactive attack detection and defence. In recent times, the fictitious environment – honeypot designed by human experience becomes popular to attract attackers and capture their interactions. However, rules-based construction of honeypots fails in preserving the privacy, boosting th ....DeepHoney: Automatic Honey Data Generation for Active Cyber Defence . This project aims to enhance the security of networks and information systems by empowering them with intelligent deception techniques to achieve proactive attack detection and defence. In recent times, the fictitious environment – honeypot designed by human experience becomes popular to attract attackers and capture their interactions. However, rules-based construction of honeypots fails in preserving the privacy, boosting the attractiveness and evolving the system. The project expects to advance deep learning and yield novel DeepHoney technologies with associated publications and open-source software. This should benefit science, society, and the economy by building the next generation of active cyber defence systems. Read moreRead less
Privacy-Preserving Fog Info System in Infrastructure-Deficient Environments. Due to Australia’s unique geographical distribution and population density, many regional or remote areas lack infrastructural support and development, including telecommunications and electricity supply. It is important to provide information and communication services in such infrastructure-deficient environments. In this project, we will develop a first-ever commercially ready Fog information system, or FogIS in shor ....Privacy-Preserving Fog Info System in Infrastructure-Deficient Environments. Due to Australia’s unique geographical distribution and population density, many regional or remote areas lack infrastructural support and development, including telecommunications and electricity supply. It is important to provide information and communication services in such infrastructure-deficient environments. In this project, we will develop a first-ever commercially ready Fog information system, or FogIS in short, to enable localised information and communication services, while preserving users' privacy, in infrastructure-deficient environments. The deployment of this system will bring great benefits to Australia’s economic growth, the quality of life, cybersecurity, and environment control in rural and regional Australia. Read moreRead less
Tuning parallel applications on software-defined supercomputers. Supercomputers are used by many Australian industries and laboratories to make better products and perform critical predictions, and it is essential that codes operate efficiently. This project aims to assist programmers in identifying performance bottlenecks in their code quickly and easily. The project expects to supersede the current methods, which are often complex and time-consuming, by developing innovative software tools and ....Tuning parallel applications on software-defined supercomputers. Supercomputers are used by many Australian industries and laboratories to make better products and perform critical predictions, and it is essential that codes operate efficiently. This project aims to assist programmers in identifying performance bottlenecks in their code quickly and easily. The project expects to supersede the current methods, which are often complex and time-consuming, by developing innovative software tools and techniques. The expected outcomes include novel software, verified by industry partners in real world case studies, ranging from life sciences to hypersonic transport. This should provide significant benefits, including the capacity for Australian industries to access world-class supercomputing technology.Read moreRead less
Privacy-preserving data processing on the cloud. This project aims to address the current lack of privacy of user data processed by common cloud computing web servers, including email, business data, and confidential files. This project aims to develop new techniques in cryptography. The anticipated outcome is a suite of practical tools enabling common cloud computing processing operations such as search, statistical analysis, and multi-user access control, to be performed efficiently while pres ....Privacy-preserving data processing on the cloud. This project aims to address the current lack of privacy of user data processed by common cloud computing web servers, including email, business data, and confidential files. This project aims to develop new techniques in cryptography. The anticipated outcome is a suite of practical tools enabling common cloud computing processing operations such as search, statistical analysis, and multi-user access control, to be performed efficiently while preserving the data privacy. These tools should provide significant benefits to the privacy of cloud users, as well as financial and reputation benefits to the IT industry, by significantly reducing the likelihood of massive user data privacy breaches in the event of a cyber-hacking attack on the cloud server.Read moreRead less
Intelligent Incident Management for Software-Intensive Systems. This project aims to develop intelligent incident management methods for software-intensive systems. Incidents are unplanned system interruptions or outages that could affect the normal operations of an organization and cause huge economic loss. This project expects to develop innovative, Artificial Intelligence (AI) based methods for automated incident management, including incident detection, incident identification, and incident ....Intelligent Incident Management for Software-Intensive Systems. This project aims to develop intelligent incident management methods for software-intensive systems. Incidents are unplanned system interruptions or outages that could affect the normal operations of an organization and cause huge economic loss. This project expects to develop innovative, Artificial Intelligence (AI) based methods for automated incident management, including incident detection, incident identification, and incident triage. Expected outcomes of the project include a set of novel methods and tools that can facilitate incident diagnosis and resolution. This project will provide significant benefits, such as improving the availability of software-intensive systems and reducing the economic loss caused by the incidents. Read moreRead less