Determining Regulators Of ILC3 In Mucosal Barrier Function And Immune Homeostasis
Funder
National Health and Medical Research Council
Funding Amount
$705,209.00
Summary
Innate lymphoid cells (ILCs) are specialized cells that defend the body against invading microorganisms at the body’s surfaces, mediate pathogen clearance and tissue repair but may also drive inflammatory conditions such as allergic asthma and inflammatory bowel disease. We will investigate the molecular switches that regulate this novel cell type and potentially uncover novel molecules or pathways for therapeutic targets.
Colorectal cancer is a leading cause of cancer-related deaths worldwide. Chronic inflammation is recognized as a predisposing factor for the development of colon cancer, but the molecular mechanisms linking inflammation and tumourigenesis have remained elusive. Our work will dissect the cellular and molecular circuitry that leads to tumourigenesis and investigate interventions aimed to significantly slow or prevent tumour formation. This work will have significant implications for treatments of ....Colorectal cancer is a leading cause of cancer-related deaths worldwide. Chronic inflammation is recognized as a predisposing factor for the development of colon cancer, but the molecular mechanisms linking inflammation and tumourigenesis have remained elusive. Our work will dissect the cellular and molecular circuitry that leads to tumourigenesis and investigate interventions aimed to significantly slow or prevent tumour formation. This work will have significant implications for treatments of intestinal inflammation and colon cancer.Read moreRead less
I am an immunologist, working to understand the function of NKT cells, and how these cells can be manipulated as a means of immune therapy for a range of immunologically related diseases.
The Transcriptional Control Of The Dendritic Cell Lineages
Funder
National Health and Medical Research Council
Funding Amount
$669,872.00
Summary
The immune system can discriminate between invading microorganisms and the body's own tissues. Dendritic cells are specialised to alert the immune system in the case of infection. In this project we aim to understand how dendritic cells are generated and how they function to control the immune response. We will achieve this aim by using state of the art genomic technologies to describe the genetic programme of dendritic cells. We hope that this knowledge will enable us to better harness the immu ....The immune system can discriminate between invading microorganisms and the body's own tissues. Dendritic cells are specialised to alert the immune system in the case of infection. In this project we aim to understand how dendritic cells are generated and how they function to control the immune response. We will achieve this aim by using state of the art genomic technologies to describe the genetic programme of dendritic cells. We hope that this knowledge will enable us to better harness the immune response in situations such as vaccination.Read moreRead less
Controlling The Haematopoietic System To Treat Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,163,220.00
Summary
The Murphy laboratory studies how the body makes blood. In people with heart disease too much blood is made that quickens the progression of heart disease. Slowing the production of blood back to normal seems to slow this progression. In this project, they will discover how and why more blood is made and ways to limit this.