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Immunomodulatory Vaccines In The Treatment Of Peanut Allergy
Funder
National Health and Medical Research Council
Funding Amount
$678,899.00
Summary
Peanut allergy is the most common cause of food-induced anaphylactic reactions in Australia and is a major burden to our healthcare system. Current clinical practice advice dietary avoidance to prevent fatal anaphylactic responses. We propose the use of an immunomodulatory vaccine to re-write the immune response to peanut antigens, from an allergic to a tolerant phenotype. This study will provide novel insights into rational approaches for manipulating immune memory to food allergens.
Establishing a next generation framework to determine the influence of intelligent water metering on householder attitudes and behaviours. This project will test competing theories on how householders respond to interactive water consumption data from smart meters. The outcome is a novel framework for intelligent water management; underpinned by innovative research into causal mechanisms linking data communication to knowledge, and the impact of knowledge on attitudes and behaviours.
Investigating Post-transcriptional Gene Regulation In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
In this program, I will enhance our understanding of cancer gene regulation and provide novel avenues for the treatment of aggressive tumours. Using own data and that from collaborators, I will determine patterns of gene regulation in blood cancers and identify markers that predict disease outcome. I aim to understand how gene regulation can transform healthy cells into tumour cells and whether personalised treatment can kill tumour cells more effectively and prevent relapse and metastasis.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100027
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Australian National Facility for Noble-Gas Radio-Isotope Measurements. Australian national facility for noble-gas radio-isotope measurements:
This facility is designed to provide researchers with the ability to accurately date water and ice cores using the natural radio-isotopes in the sample. Radiocarbon dating has been a revolutionary tool in providing answers to a range of questions in anthropology, archaeology and the earth sciences. However, radiocarbon dating has a strong limitation in th ....Australian National Facility for Noble-Gas Radio-Isotope Measurements. Australian national facility for noble-gas radio-isotope measurements:
This facility is designed to provide researchers with the ability to accurately date water and ice cores using the natural radio-isotopes in the sample. Radiocarbon dating has been a revolutionary tool in providing answers to a range of questions in anthropology, archaeology and the earth sciences. However, radiocarbon dating has a strong limitation in that it can only date periods from 1000–50 000 years: the use of radioactive noble-gas isotopes can extend this range out to 1 year to 1 million years. This capability in the new facility is expected to support new understanding of processes in artesian reservoirs, ocean currents and geology that may affect questions of water availability, climate and environmental change.Read moreRead less
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Developing a truly intelligent water meter through advanced data analytics. Developing a truly intelligent water meter through advanced data analytics. This project aims to develop intelligent pattern recognition algorithms using international data sets to autonomously categorise household water consumption data into end-uses (e.g. showers, leaks). Despite intelligent meters, big data chokes rather than enables decision making for customers and utilities. This project will resolve information sy ....Developing a truly intelligent water meter through advanced data analytics. Developing a truly intelligent water meter through advanced data analytics. This project aims to develop intelligent pattern recognition algorithms using international data sets to autonomously categorise household water consumption data into end-uses (e.g. showers, leaks). Despite intelligent meters, big data chokes rather than enables decision making for customers and utilities. This project will resolve information synthesis concerns using a combination of non-linear blind source separation techniques adapted from the pattern recognition, signal processing and decision science fields. Expected outcomes are that utilities will be leaders of sustainable water use in the information age, and that customers can use phones to access real-time data of water consumption.Read moreRead less
The Functional Roles Of ADAMs In The Regulation Of Embryo Implantation.
Funder
National Health and Medical Research Council
Funding Amount
$211,527.00
Summary
The initiation of pregnancy in humans and rodents hinges upon the ability of the embryo to attach to the wall of the uterus and invade into the uterine tissue. This process of embryo implantation is tightly regulated and depends on the secretion of enzymes and regulators of these enzymes. A newly identified family of enzymes which might be important in this process is the ADAMs family. These enzymes have the potential to facilitate both cell attachment and cell invasion and also to activate othe ....The initiation of pregnancy in humans and rodents hinges upon the ability of the embryo to attach to the wall of the uterus and invade into the uterine tissue. This process of embryo implantation is tightly regulated and depends on the secretion of enzymes and regulators of these enzymes. A newly identified family of enzymes which might be important in this process is the ADAMs family. These enzymes have the potential to facilitate both cell attachment and cell invasion and also to activate other enzymes and growth factors. Recent studies in our laboratory have shown the ADAMs to be expressed both at the most invasive time of implantation and when invasion is being down-regulated. This project will examine the role of the ADAMs in embryo implantation facilitating attachment and invasion into the uterus by acting enzymatically on the uterine tissue and by activating other enzymes. It will also determine the role of ADAMs in down-regulating invasion potentially by activating a growth factor, TNF-alpha. Knowledge of this process and particularly its regulation is important for the treatment of pregnancy associated diseases that arise from improper implantation. These include infertility, placenta accreta, choriocarcinoma, miscarriage and pre-eclampsia. Furthermore, an understanding of the regulation of implantation will contribute to the treatment of other conditions associated with cell invasion such as cancer metastasis.Read moreRead less
Reducing the deleterious impacts of clay particle interactions with valuable minerals in copper and gold processing. This project seeks to understand the rheological behaviour of clay minerals and the effect of the viscosity caused by clay minerals on gas dispersion, the transport of network structures and the locking of the structures in the froth in mineral flotation. Novel methods will be developed to improve flotation separation by reducing the viscosity.
Molecular and immunological approaches to managing Australia's seafood allergy epidemic. Seafood is an increasingly important cause of food allergy. Novel insight into the functions of why and how proteins from seafood develop to potent allergens will lead to the development of better diagnostics and therapeutics. This will assist patients to better manage their serious food allergy.