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The aim of this project is to develop mathematical models and computer software capable of predicting immune responses to infection and disease. This “artificial immune system” should lead to improved vaccine design and better understanding of what causes the immune system to attack its own body, causing autoimmune disease, or fail to respond, causing immunodeficiency. This enabling science could then lead to improvements in treatment for a range of conditions of clinical importance.
Immune Regulation During Uncomplicated And Severe P. Falciparum And P. Vivax Malaria
Funder
National Health and Medical Research Council
Funding Amount
$292,639.00
Summary
Malaria is a major global disease that kills over 1 million people every year. Immune responses induced during infection help fight the infection but can also cause tissue damage and thereby worsen disease. This study will determine differences in cellular immune responses during uncomplicated and severe malaria. Better understanding of the role of immune cells in response to infection and disease progression will assist the development of novel treatment interventions and vaccine development.
The Role Of Self Reactive T Cells In The Normal TCR Repertoire
Funder
National Health and Medical Research Council
Funding Amount
$363,601.00
Summary
The immune system is highly regulated and sophisticated in order to distinguish foreign invaders from our own body. Once control is lost in this system, mistakes can happen, and autoimmunity, attack of ones self may result. Surprisingly potentially dangerous ‘fighter’ T cells can be readily found in healthy individuals whom are free from autoimmunity. The aim of this project is to understand how we can survive with these potentially harmful T cells around and what may activate them.
The Investigation Of Immune Function In Mice Deficient In RNA-binding Molecules.
Funder
National Health and Medical Research Council
Funding Amount
$419,737.00
Summary
Our immune system is delicately balanced between fighting off bugs and destroying infected cells yet protecting healthy cells within the body. The ways in which the immune system responds to attack is regulated by certain genes within the body. This project is focussing on cutting edge research that describes a newly identified way of fine-tuning the immune system. We are studying RNA-binding molecules that can bind to and block genes involved in immune function.
Novel Methods To Diagnose Clinical Egg Allergy And Predict Prognostic Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Australia has the highest rate of food allergy in the world. Despite ongoing research into the area, there is currently no cure, with patient avoidance the most effective way to prevent food reactions. A food challenge is the gold standard for food allergy diagnosis. Although definitive, it is associated with a risk of anaphylaxis. My research aims to identify the biological differences between having food allergy and not having food allergy to develop novel diagnostic methods.