Discovery Early Career Researcher Award - Grant ID: DE210101031
Funder
Australian Research Council
Funding Amount
$458,120.00
Summary
Defining the structural basis of lipid mediated T cell immunity. This project aims to undertake discovery research to investigate the molecular mechanisms underpinning the role of lipids in T cell immunity: an emerging area of immense biological significance. The anticipated goal is to generate new knowledge in the areas of the life sciences, by using a multidisciplinary approach that includes structural biology, mass spectrometry, biophysics, and cellular immunology, to gain fundamental insight ....Defining the structural basis of lipid mediated T cell immunity. This project aims to undertake discovery research to investigate the molecular mechanisms underpinning the role of lipids in T cell immunity: an emerging area of immense biological significance. The anticipated goal is to generate new knowledge in the areas of the life sciences, by using a multidisciplinary approach that includes structural biology, mass spectrometry, biophysics, and cellular immunology, to gain fundamental insight into molecular determinants that govern lipid mediated immunity. Expected outcomes and benefits of this project include building international and interdisciplinary collaborations to enhance national research capacity, and provide marked advancement of core knowledge in the biological sciences.Read moreRead less
Investigating the atomic structure of an immune cell inhibitory receptor. T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cel ....Investigating the atomic structure of an immune cell inhibitory receptor. T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cells, termed the Lymphocyte activation gene-3 (LAG-3). The proposal utilises a combination of cellular immunology and structural biology to gain insight into the form and function of the LAG-3 molecule. Ultimately this fundamental knowledge can be used by the biotechnology industry.Read moreRead less