High-resolution multiscale modelling of pandemics: COVID-19 and beyond. The project aims to develop high-resolution computational models for pandemic mitigation and control, focussing on the novel coronavirus and its emerging variants, and leveraging demographic, genomic and epidemiological data. It expects to rigorously compare multi-scale effects of complex vaccination and social distancing strategies and quantify optimal responses under the COVID-19 induced uncertainty. The intended outcomes ....High-resolution multiscale modelling of pandemics: COVID-19 and beyond. The project aims to develop high-resolution computational models for pandemic mitigation and control, focussing on the novel coronavirus and its emerging variants, and leveraging demographic, genomic and epidemiological data. It expects to rigorously compare multi-scale effects of complex vaccination and social distancing strategies and quantify optimal responses under the COVID-19 induced uncertainty. The intended outcomes include computational models of how the most infectious viral variants emerge and spread in presence of interventions, how to predict the outbreaks, and which are the most vulnerable communities. This should make a significant economic and social impact, improving population health while maintaining a resilient economy.Read moreRead less
Lifespan-dependent molecular shaping of the T cell receptor repertoire. Mammals have an intricate and highly complex immune system, whose function alters throughout life. Why and how this occurs is very unclear however, yet remains a crucial question. This project aims to provide fundamental knowledge on how the human lifespan shapes specific T cell receptors and determine molecular mechanisms underlying gain-of-function and loss-of-function during immunologically distinct phases of life. This p ....Lifespan-dependent molecular shaping of the T cell receptor repertoire. Mammals have an intricate and highly complex immune system, whose function alters throughout life. Why and how this occurs is very unclear however, yet remains a crucial question. This project aims to provide fundamental knowledge on how the human lifespan shapes specific T cell receptors and determine molecular mechanisms underlying gain-of-function and loss-of-function during immunologically distinct phases of life. This project will provide analysis of multi-dimensional, high throughput datasets to identify fundamental links between the transcriptional landscape and TCR signatures across human lifespan, thus will significantly answer key immunological questions in the field.Read moreRead less