History in their bones: A diachronic, bioarchaeological study of diet, mobility and social organisation from Cambodian skeletal assemblages. Australia will further enhance its role as an innovator in the archaeology of SE Asia through this cross-disciplinary, international collaboration on the mobility, health, age and diet in ancient Cambodia. Local collaborations will be expanded and academic and cultural relations with Cambodia will be reinforced and strengthened. This research will expand ....History in their bones: A diachronic, bioarchaeological study of diet, mobility and social organisation from Cambodian skeletal assemblages. Australia will further enhance its role as an innovator in the archaeology of SE Asia through this cross-disciplinary, international collaboration on the mobility, health, age and diet in ancient Cambodia. Local collaborations will be expanded and academic and cultural relations with Cambodia will be reinforced and strengthened. This research will expand understanding of Cambodian history and underscore its pivotal role in mainland SE Asian archaeology. Australia's advancement of knowledge about Cambodia's rich cultural antiquity will be recognized worldwide by a global community acutely mindful of the losses to culture and heritage endured by Cambodia in the recent past.Read moreRead less
Intelligent pattern recognition of water end uses enabling recommendations. This project aims to develop a hybrid machine learning method for autonomously disaggregating high- and low-resolution water flow data received from smart meters into discrete end-use events, and a customised recommender system for efficient resource demand management. Project novelty and significance relates to this coupling and autonomous disaggregation of datasets from advanced sensors, enabling more efficient utility ....Intelligent pattern recognition of water end uses enabling recommendations. This project aims to develop a hybrid machine learning method for autonomously disaggregating high- and low-resolution water flow data received from smart meters into discrete end-use events, and a customised recommender system for efficient resource demand management. Project novelty and significance relates to this coupling and autonomous disaggregation of datasets from advanced sensors, enabling more efficient utility services delivery and lower customer utility bills. Project benefits include enabling utilities to better manage and plan resources in the information age, while empowering customers with real-time water end-use data and behaviour changing consumption recommendations.Read moreRead less
Functional magnetic resonance imaging: Decoding the palimpsest. This project aims to model the dynamics of functional magnetic resonance imaging (fMRI) to image new physiology and attain higher resolution. This will enable new aspects of brain dynamics to be imaged, achieving higher resolution and improving interpretation. This project is expected to improve the use and power of fMRI, unlock new avenues for probing brain function and save experimental costs. This will have many uses in neuroscie ....Functional magnetic resonance imaging: Decoding the palimpsest. This project aims to model the dynamics of functional magnetic resonance imaging (fMRI) to image new physiology and attain higher resolution. This will enable new aspects of brain dynamics to be imaged, achieving higher resolution and improving interpretation. This project is expected to improve the use and power of fMRI, unlock new avenues for probing brain function and save experimental costs. This will have many uses in neuroscience, brain imaging technology and fMRI analysis software.Read moreRead less
Structure and function of human zinc transporter membrane proteins. The aim of this project is to create fundamental new knowledge on how important mammalian membrane proteins operate. Membrane proteins are key drug targets and are significantly under-represented in structural databases. The project plans to combine innovative membrane protein screening technology with gene expression, structural biology, biophysics and cell biology. The project outcomes may elucidate specific molecular mechanis ....Structure and function of human zinc transporter membrane proteins. The aim of this project is to create fundamental new knowledge on how important mammalian membrane proteins operate. Membrane proteins are key drug targets and are significantly under-represented in structural databases. The project plans to combine innovative membrane protein screening technology with gene expression, structural biology, biophysics and cell biology. The project outcomes may elucidate specific molecular mechanisms underpinning the essential biological process of zinc homeostasis.Read moreRead less
New guardians of the mucosa: Molecular characterisation of M cell biology. We aim to completely define the cellular and molecular biology of gut and lung M cells for the first time. We will elucidate how they develop, are regulated and function at a molecular level, and how M cells maintain normal gut and lung tissues and induce immune responses to protect against microbial challenges. In the future, the new insights will be essential pre-requisites for the development of mucosal-based intervent ....New guardians of the mucosa: Molecular characterisation of M cell biology. We aim to completely define the cellular and molecular biology of gut and lung M cells for the first time. We will elucidate how they develop, are regulated and function at a molecular level, and how M cells maintain normal gut and lung tissues and induce immune responses to protect against microbial challenges. In the future, the new insights will be essential pre-requisites for the development of mucosal-based interventions and vaccines that protect the gut and lung from infectious and inflammatory issues. The harnessing of effective immune responses to control such challenges, are of enormous fundamental and long-standing biological interest, and are amongst the most important areas of current scientific research.Read moreRead less