The epigenetic blueprint for T cell differentiation: a genomic view. A cardinal feature of adaptive immune cell activation is the initiation of a program of differentiation that results in acquisition and long term maintenance of lineage-speci?c effector function. This proposal aims to map and dissect genome wide molecular changes that occur at different stages of immune cell differentiation and identify key factors that regulating these changes. It is expected that distinct genomic signatures, ....The epigenetic blueprint for T cell differentiation: a genomic view. A cardinal feature of adaptive immune cell activation is the initiation of a program of differentiation that results in acquisition and long term maintenance of lineage-speci?c effector function. This proposal aims to map and dissect genome wide molecular changes that occur at different stages of immune cell differentiation and identify key factors that regulating these changes. It is expected that distinct genomic signatures, and the mechanisms indicative of effective immune cell differentiation will be identified. This proposal will provide insights into key mechanisms that result in reprogramming of immune cell function and memory and have implications for understanding general cellular differentiation.Read moreRead less
How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, ....How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, this project expects to provide insights into non-coding regulatory element reprogramming and control of immune cell function and memory with implications for understanding general cellular differentiation.Read moreRead less
Auger, Quantum Electro-Dynamics, Axions and New Technology. New technology developed by Australia, Sweden and the United States will be applied to major questions about the application of relativistic quantum mechanics to atomic structure and dynamics and spectroscopy, especially including critical issues in quantum electro-dynamics for atomic physics and applications. Discrepancies in quantum electro-dynamics have dominated international debate for decades, with claimed explanations annually fa ....Auger, Quantum Electro-Dynamics, Axions and New Technology. New technology developed by Australia, Sweden and the United States will be applied to major questions about the application of relativistic quantum mechanics to atomic structure and dynamics and spectroscopy, especially including critical issues in quantum electro-dynamics for atomic physics and applications. Discrepancies in quantum electro-dynamics have dominated international debate for decades, with claimed explanations annually failing to reveal the cause. Also a pattern of discrepancies has been seen at X-ray energies in first row metal atoms, with a similar sign and magnitude. A combined experimental an theoretical investigation will aim to reveal new light on these anomalies and serve to develop our understanding of the universe.Read moreRead less
microRNAs and the control of T lymphocyte differentiation, function and malignant transformation. The molecular mechanism of the immune system is not completely understood. This project will investigate how transcription factors and microRNAs, two major types of regulatory molecules work together to control immune responses. The results from this research will assist in the design of better vaccination strategies and treat certain lymphomas.
Dynamic tomography: high-resolution, four-dimensional imaging of processes. This project will develop imaging technology that allows us to collect detailed, three dimensional movies of complex, microscopic processes in a laboratory. This technology will have applications in soil science, biology, oil extraction, and carbon sequestration.