Discovery Early Career Researcher Award - Grant ID: DE160100742
Funder
Australian Research Council
Funding Amount
$315,000.00
Summary
Biofilms in two-dimensional turbulent flows:effects on Lagrangian transport. This project aims to investigate how surface biofilms affect flows at the ocean surface. Great stretches of the ocean surface are covered by an organic microlayer called biofilm. Flows at the ocean surface are a crucial part of climate machinery, and biofilms have profound, largely unexplored effects on these flows. There is no fundamental understanding of how biofilms affect fluid motion. This project aims to use labor ....Biofilms in two-dimensional turbulent flows:effects on Lagrangian transport. This project aims to investigate how surface biofilms affect flows at the ocean surface. Great stretches of the ocean surface are covered by an organic microlayer called biofilm. Flows at the ocean surface are a crucial part of climate machinery, and biofilms have profound, largely unexplored effects on these flows. There is no fundamental understanding of how biofilms affect fluid motion. This project aims to use laboratory models and new measurement techniques to study and quantify the impact of biofilms on turbulent transport. Understanding these effects is important in a time of climate change and this knowledge may also help address environmental issues related to spreading of pollutants and flow control at the ocean surface.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101201
Funder
Australian Research Council
Funding Amount
$366,404.00
Summary
Planar Brownian motion and complex analysis. This project will study a number of related problems concerning both Brownian motion and complex analysis. These include questions about Brownian exit time, conformally invariant processes such as Stochastic Loewner Evolution, and the fundamentals of complex analysis. Many of these questions are at the forefront of modern probability theory. The outcomes of this project will bring the questions considered into a position of prominence in the fields of ....Planar Brownian motion and complex analysis. This project will study a number of related problems concerning both Brownian motion and complex analysis. These include questions about Brownian exit time, conformally invariant processes such as Stochastic Loewner Evolution, and the fundamentals of complex analysis. Many of these questions are at the forefront of modern probability theory. The outcomes of this project will bring the questions considered into a position of prominence in the fields of probability and analysis, and bring international attention to Australia as a hub of important research.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100364
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Understanding winds: energy transfer in rotating turbulent fluids. The Earth's rotation affects how large atmospheric winds and cyclones interact with each other and with the surface of our planet. This controls how the wind energy is distributed in the global atmosphere. By studying rotating turbulence in laboratory experiments, we can improve our understanding of atmospheric dynamics and make better predictions in meteorology, and atmospheric physics.
Discovery Early Career Researcher Award - Grant ID: DE140100620
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Inference, control and protection of interdependent spatial networked structures. Networked structures are everywhere and modern societies largely depend on their proper functioning. Some of these networks are spatial with each node having a geographical tag. Examples include power grids, the internet and transportation networks. These networks are often interdependent where their functioning depends on each other. This project will establish a mathematical framework to efficiently observe and c ....Inference, control and protection of interdependent spatial networked structures. Networked structures are everywhere and modern societies largely depend on their proper functioning. Some of these networks are spatial with each node having a geographical tag. Examples include power grids, the internet and transportation networks. These networks are often interdependent where their functioning depends on each other. This project will establish a mathematical framework to efficiently observe and control interdependent spatial networks and develop design strategies in order to maximise residency of spatial networks against catastrophic failures in their components. The outcomes of the project will protect the Australian power grid and transportation networks against random and intentional failures. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100432
Funder
Australian Research Council
Funding Amount
$394,308.00
Summary
Defining the mechanisms of tissue-resident memory T cell development. We have recently identified a subset of T cells that reside at points of pathogen entry where they can effectively control infection. The ability of these T cells to offer local immunity has caused a paradigm shift in our view of how T cells protect against infection, drastically changing the way we think about designing T cell vaccines. This project aims to characterise this novel T cell subset, defining the fundamental requi ....Defining the mechanisms of tissue-resident memory T cell development. We have recently identified a subset of T cells that reside at points of pathogen entry where they can effectively control infection. The ability of these T cells to offer local immunity has caused a paradigm shift in our view of how T cells protect against infection, drastically changing the way we think about designing T cell vaccines. This project aims to characterise this novel T cell subset, defining the fundamental requirements for their formation and maintenance. This will lead to a greater understanding of their biology, which will be of significance for the development of novel vaccination strategies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101340
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Subversion of innate immune responses by pathogenic Escherichia coli. This project will determine how bacteria that cause diarrhoeal diseases prevent the immune system from signalling efficiently. It will provide important information not only about how the bacteria establish disease, but also provide insight into the host response in the early stages of infection.
Discovery Early Career Researcher Award - Grant ID: DE140101375
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
The forest and the trees: How global brain rhythms facilitate local information processing. One of the greatest challenges in understanding the brain is the enormous range of scales it operates on, from single neurons a few microns across to entire hemispheres on the scale of tens of centimetres. This project will investigate how large-scale brain rhythms influence and facilitate information processing, particularly motor control, among small networks of individual neurons. The research question ....The forest and the trees: How global brain rhythms facilitate local information processing. One of the greatest challenges in understanding the brain is the enormous range of scales it operates on, from single neurons a few microns across to entire hemispheres on the scale of tens of centimetres. This project will investigate how large-scale brain rhythms influence and facilitate information processing, particularly motor control, among small networks of individual neurons. The research questions will be addressed by combining detailed computer simulations with data-driven analyses of empirical human and monkey brain dynamics. The outcomes of this project will provide a richer understanding of how our brains encode and process information, leading to practical benefits such as improved control of artificial limbs.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100223
Funder
Australian Research Council
Funding Amount
$385,735.00
Summary
Diophantine approximation, transcendence, and related structures. Sequences produced by low-complexity structures are objects of importance to mathematics, linguistics and theoretical computer science. In the 1960s, Chomsky and Schützenberger formalised and popularised a hierarchy of such objects. In the 1920s, Mahler provided a corresponding analytic framework, which has proven extremely useful for analysing the algebraic character of low-complexity real numbers. This project will further devel ....Diophantine approximation, transcendence, and related structures. Sequences produced by low-complexity structures are objects of importance to mathematics, linguistics and theoretical computer science. In the 1960s, Chomsky and Schützenberger formalised and popularised a hierarchy of such objects. In the 1920s, Mahler provided a corresponding analytic framework, which has proven extremely useful for analysing the algebraic character of low-complexity real numbers. This project will further develop Mahler's method in order to investigate the connection between the algebraic and arithmetic properties of real numbers and the various Chomskian complexity measures of those numbers. The results of this proposal will advance our knowledge of the nature of "randomness" in low-complexity arithmetic sequences.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100292
Funder
Australian Research Council
Funding Amount
$426,018.00
Summary
Defining the basis of unconventional immune cell development. This project aims to undertake discovery research to characterise the transcriptional programs that underpin the development of unconventional immune cells. This project expects to generate new knowledge in the area of developmental immunology by using cutting-edge molecular and cellular techniques to examine the seeding of immune cells. It is expected that this project will advance our understanding of immune cell biology and the pro ....Defining the basis of unconventional immune cell development. This project aims to undertake discovery research to characterise the transcriptional programs that underpin the development of unconventional immune cells. This project expects to generate new knowledge in the area of developmental immunology by using cutting-edge molecular and cellular techniques to examine the seeding of immune cells. It is expected that this project will advance our understanding of immune cell biology and the programs that control them. Significantly strengthening national excellence in unconventional immune cell research and providing innovative methodology. This should provide significant benefits, such as a comprehensive open-access transcriptional map of developing unconventional immune cells.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100165
Funder
Australian Research Council
Funding Amount
$451,900.00
Summary
Engineering T cells to promote peripheral immunity. Tissue-resident memory T cells (TRM) are key for immune protection against infections and cancer. This has led to much interest in understanding how these immune cells develop, although elucidation of molecules that regulate TRM are still scarce. This project aims to (i) identify genetic drivers of TRM in peripheral organs and (ii) modulate TRM generation utilising state-of-the-art genetic engineering techniques. Expected outcomes include gener ....Engineering T cells to promote peripheral immunity. Tissue-resident memory T cells (TRM) are key for immune protection against infections and cancer. This has led to much interest in understanding how these immune cells develop, although elucidation of molecules that regulate TRM are still scarce. This project aims to (i) identify genetic drivers of TRM in peripheral organs and (ii) modulate TRM generation utilising state-of-the-art genetic engineering techniques. Expected outcomes include generating new knowledge that will contribute to the development of novel therapeutics against infectious disease and cancer, together with the benefit of promoting national and international collaboration with the ultimate goal of improving health.Read moreRead less