Virus and host genes and the outcome of infection. Viruses cause infection of all animals including people and the outcome of infection is highly variable. This project aims to use genetics to explain why some animals are more susceptible to particular virus infections and some strains of virus cause more severe diseases. The project will also explore whether all cells are similarly susceptible to killing by viruses.
Understanding the mechanisms of ion conduction and drug action in voltage gated sodium channels. Voltage-gated sodium channels initiate electrical impulses in nerve and muscle and are the target of many local anaesthetic, anti-epileptic and anti-arrythmic drugs. The publication of atomic resolution structures of homologous proteins from bacteria in the last 18 months has now made it possible to gain a detailed understanding of how these channels work, and how they are influenced by drugs. This p ....Understanding the mechanisms of ion conduction and drug action in voltage gated sodium channels. Voltage-gated sodium channels initiate electrical impulses in nerve and muscle and are the target of many local anaesthetic, anti-epileptic and anti-arrythmic drugs. The publication of atomic resolution structures of homologous proteins from bacteria in the last 18 months has now made it possible to gain a detailed understanding of how these channels work, and how they are influenced by drugs. This project aims to determine the basis of ion permeation and selectivity in the channels and explain the mechanisms of action for a number of common drugs. This will provide a foundation for future drug development to target specific channels for improved treatment of epilepsy, chronic pain and arrythmias. Read moreRead less
Mosquito-borne viruses - how they cause disease and novel approaches to prevention. In Australia, Ross River virus (RRV) is the most common insect borne virus that affects human health. There were more than 60,000 confirmed cases of RRV between 1993 and 2008. While not fatal, the disease is responsible for significant morbidity that has both social and economic costs for the individual, their family and the community. This project has several national benefits. It will elucidate whether there is ....Mosquito-borne viruses - how they cause disease and novel approaches to prevention. In Australia, Ross River virus (RRV) is the most common insect borne virus that affects human health. There were more than 60,000 confirmed cases of RRV between 1993 and 2008. While not fatal, the disease is responsible for significant morbidity that has both social and economic costs for the individual, their family and the community. This project has several national benefits. It will elucidate whether there is an association between RRV strain and the severity of disease and if there are human factors that affect the seriousness of symptoms. Knowledge of both of these could provide new avenues for the design of prevention and treatment strategies.Read moreRead less
Engineering a technology platform for organoids. Protein delivery technologies hold great potential to improve organoids (miniature organs used as in vitro models), allowing a deep understanding of development. However, current limitations must be overcome - particularly cost, precision, and efficacy. This project will engineer delivery materials to improve the efficacy of organoids, allowing control over the location and timing of protein delivery. Outcomes will include a technology platform o ....Engineering a technology platform for organoids. Protein delivery technologies hold great potential to improve organoids (miniature organs used as in vitro models), allowing a deep understanding of development. However, current limitations must be overcome - particularly cost, precision, and efficacy. This project will engineer delivery materials to improve the efficacy of organoids, allowing control over the location and timing of protein delivery. Outcomes will include a technology platform of immediate use in the agriculture sector and for animal model alternatives. The benefit will be widespread, ensuring the growth and sustainability of our health and agriculture sector. The project will increase public understanding of protein delivery technologies, aiding in technology adoption.Read moreRead less
Understanding grassy woodlands as whole ecosystems. Restoring Australia's once vast grassy woodlands needs a sound understanding of the whole ecosystem and robust scientific evidence to inform conservation action. This project will generate such evidence by establishing a National Outdoor Laboratory to inform the sustainable management of our nation's precious remaining woodlands.
Religion, state and social inclusion: lessons from schools in three countries. Social inclusion is a priority for governments in Australia and overseas. Religious schools can be exclusionary, but can also provide safe havens for religious minorities. This project analyses a range of educational controversies in France, USA and Australia to propose programs and policies that enhance inclusion in religiously diverse societies.
Global Indigenous rights and local effect in Central Australia: tracing relations of power and locating potentialities. This ethnographic study investigates the practice of Indigenous rights in central Australia by exploring the apparently entrenched disjunctures between the declaration of rights and social fact. Working with Aboriginal people, government and non-government organisations will reveal how rights are understood and negotiated, thus locating new pathways for change.
Addressing time scarcity: feasible strategies for a healthy future. Lack of time is the main reason people say they don't exercise, take public transport or eat healthy food, and for many Australians (especially parents who combine working with raising children) time pressure is acute. This program of research will provide ways to reduce time barriers, to make healthy and sustainable living more feasible.
Social relations and social engagement in older adulthood: implications for health, well being and cognition. This project will examine the nature of changes in peoples social networks that occur with age and the effects of these changes on health and well being in later life. The project will use information collected as part of several ongoing Australian studies of ageing and will have implications for social policy.
Strengthening political representation in an era of democratic change. This project aims to understand and strengthen how politicians represent their constituents. As trust in politics declines, there is more pressure on politicians to engage with citizens. Understanding how these demands are reshaping the representative work of politicians is crucial to building trust and legitimacy in modern democracies. By interviewing and observing Australian politicians, this research will build important k ....Strengthening political representation in an era of democratic change. This project aims to understand and strengthen how politicians represent their constituents. As trust in politics declines, there is more pressure on politicians to engage with citizens. Understanding how these demands are reshaping the representative work of politicians is crucial to building trust and legitimacy in modern democracies. By interviewing and observing Australian politicians, this research will build important knowledge about the dynamics, demands and practices of contemporary representation. A national and international audit of novel ways to engage constituents will lead to valuable resources that politicians and citizens can use to assess and improve representative relationships, enabling stronger democratic institutions.
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