Dissecting The Great Ophthalmic Masquerade: The Global Giant Cell Arteritis Genomics Consortium.
Funder
National Health and Medical Research Council
Funding Amount
$583,269.00
Summary
Giant cell arteritis (GCA) is the most common form of vasculitis in people over 50 years of age. If untreated it can cause catastrophic complications including blindness, though this can be prevented if treated early. Although there is clear evidence for a role of genetic factors in GCA, these have been little studied. We have established an Australian-led International consortium, with clinical, basic science and statistical expertise to thoroughly investigate this devastating disease.
The Control of Memory Access. The topic of control processes in memory access is central to most of the big questions about human memory such as; why we forget, what produces spectacular and tragic memory failures (e.g.,lighting a match to check the level of petrol in a tank) and the role of context in familiarity and recollection. Because of the centrality of the problems addressed there will be many applications for the results. The long term results will include better models for human ope ....The Control of Memory Access. The topic of control processes in memory access is central to most of the big questions about human memory such as; why we forget, what produces spectacular and tragic memory failures (e.g.,lighting a match to check the level of petrol in a tank) and the role of context in familiarity and recollection. Because of the centrality of the problems addressed there will be many applications for the results. The long term results will include better models for human operators which can be used in both civilian (e.g., air traffic control) and military applications. Other areas of application will include how we measure memory impairment, why we make errors in industrial settings, and the nature of memory deficits as we age. Read moreRead less
Using Converging Methodologies to Understand Episodic and Semantic Memory. The use of four converging methodologies and a new objective measure of implicit/explicit memory will produce a more fundamental understanding of the relationship between pre-existing and episodic memories. The results will be relevant to the current debate over repressed and false memories. The research will also provide more stringent tests of techniques and methods that are having a large impact in applied research ....Using Converging Methodologies to Understand Episodic and Semantic Memory. The use of four converging methodologies and a new objective measure of implicit/explicit memory will produce a more fundamental understanding of the relationship between pre-existing and episodic memories. The results will be relevant to the current debate over repressed and false memories. The research will also provide more stringent tests of techniques and methods that are having a large impact in applied research on aging, drug states etc.Read moreRead less
The Tasmanian Healthy Brain Project: A Longitudinal Intervention Study To Reduce The Risk Of Ageing-related Cognitive Decline And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$878,792.00
Summary
It has been proposed that engagement in purposeful complex mental stimulation provides protection against dementia. The Tasmanian Healthy Brain Project (THBP) is a unique, large-scale prospective trial that examines whether university-level study in older adult population reduces ageing-related cognitive decline and risk of dementia. This project will also examine how an individual’s genetic profile may influence the potential benefits of complex mental stimulation as well as risk of dementia.
Immunomodulatory Vaccines In The Treatment Of Peanut Allergy
Funder
National Health and Medical Research Council
Funding Amount
$678,899.00
Summary
Peanut allergy is the most common cause of food-induced anaphylactic reactions in Australia and is a major burden to our healthcare system. Current clinical practice advice dietary avoidance to prevent fatal anaphylactic responses. We propose the use of an immunomodulatory vaccine to re-write the immune response to peanut antigens, from an allergic to a tolerant phenotype. This study will provide novel insights into rational approaches for manipulating immune memory to food allergens.
A new approach to reversing and preventing immune-mediated diseases. Chronic inflammatory diseases affect up to 20 per cent of Australians. These diseases reduce wellbeing and life potential and shorten lifespan. This project addresses the urgent need for effective therapies and focuses on developing strategies for disease cure and prevention.
The many faces of threat: An investigation of animal, interpersonal and intergroup threat. Threat to personal safety can take a number of guises, a snake in the grass, an angry neighbour or, increasingly often in our modern world, a stranger who looks different. The present project will investigate the manner in which we respond to these threats, whether these responses can be modulated and what determines the threatening nature of an event. A better understanding of how we react to real or p ....The many faces of threat: An investigation of animal, interpersonal and intergroup threat. Threat to personal safety can take a number of guises, a snake in the grass, an angry neighbour or, increasingly often in our modern world, a stranger who looks different. The present project will investigate the manner in which we respond to these threats, whether these responses can be modulated and what determines the threatening nature of an event. A better understanding of how we react to real or perceived threats, in particular those involving other humans, will aid our understanding of human behaviour in an ever faster changing environment, both in our region and more broadly. Read moreRead less
The recognition of human body shape in infancy. Newborn infants have expectations about human faces and it is hypothesised that this early knowledge allows them to identify and begin to engage with other humans. While faces are central to identification of and communication with others, human bodies are also highly informative and expressive, yet to date there is almost no research on infants? expectations about human bodies. This proposal details six studies that will systematically explore a ....The recognition of human body shape in infancy. Newborn infants have expectations about human faces and it is hypothesised that this early knowledge allows them to identify and begin to engage with other humans. While faces are central to identification of and communication with others, human bodies are also highly informative and expressive, yet to date there is almost no research on infants? expectations about human bodies. This proposal details six studies that will systematically explore and document the development of infants? expectations about human bodies, and will further test the theory that infants? earliest social interactions are dependent upon representations of the human face and body.Read moreRead less
Maternal input and theory of mind development in infancy and early childhood. When parents talk to their children, they influence their development both by what they say and how they say it. Building on previous ARC-funded work, this project will examine how and to what extent parents converse about mental states with their children, as well as investigating the influence of such parental talk on the child's socio-cognitive understanding of others' minds and emotions. Results promise to supply ....Maternal input and theory of mind development in infancy and early childhood. When parents talk to their children, they influence their development both by what they say and how they say it. Building on previous ARC-funded work, this project will examine how and to what extent parents converse about mental states with their children, as well as investigating the influence of such parental talk on the child's socio-cognitive understanding of others' minds and emotions. Results promise to supply important insights into the complex interaction of biology and socialisation in normal development, and will also serve as a foundation for future interventions to help children who are at risk for social problems.Read moreRead less
Social Influences on Five Key Steps in Understanding Mind for Children with Autism, Deafness or Typical Development. Via new knowledge on five crucial steps in the growth of social understanding, our findings will serve the ARC's Research Priority #2 to promote good health and a healthy start in life. We will discover what kinds of parenting, social interaction and conversation foster optimal progress through the steps for typical children, and how the delays discovered in our earlier research ....Social Influences on Five Key Steps in Understanding Mind for Children with Autism, Deafness or Typical Development. Via new knowledge on five crucial steps in the growth of social understanding, our findings will serve the ARC's Research Priority #2 to promote good health and a healthy start in life. We will discover what kinds of parenting, social interaction and conversation foster optimal progress through the steps for typical children, and how the delays discovered in our earlier research among those with autism or deafness can be offset or overcome. Also, Australia's position as a world leader in scientific studies of child social cognition will be further strengthened by our methodological and theoretical contributions.
Read moreRead less