Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Towards a high density silicon phase change memory device. This project builds upon our exciting recent findings that amorphous silicon can be transformed to a conducting crystalline phase following small-scale indentation. Furthermore the process is reversible as re-indentation can induce a transformation back to insulating amorphous silicon. This process appears to occur in extremely small (nanoscale) volumes of silicon. We plan to explore the viability of exploiting this behaviour to develo ....Towards a high density silicon phase change memory device. This project builds upon our exciting recent findings that amorphous silicon can be transformed to a conducting crystalline phase following small-scale indentation. Furthermore the process is reversible as re-indentation can induce a transformation back to insulating amorphous silicon. This process appears to occur in extremely small (nanoscale) volumes of silicon. We plan to explore the viability of exploiting this behaviour to develop an entirely new information storage system: a high-density silicon phase change memory. This project aims to study small-scale transformation behaviour in silicon and to design demonstrator memory devices based on both micro-electromechanical systems and solid state technologies.Read moreRead less
Characterisation of nanobubbles. Surprisingly, nano-sized bubbles have recently been found to exist in aqueous solutions. Classical theory tells us they should rapidly dissolve, yet they are stable for several days, a phenomenon which has only recently been explained. Despite this, nanobubbles are already used in cleaning processes and appear to have significant health benefits. They are being investigated in treatments for asthma and neurodegenerative diseases. In collaboration with a pharmaceu ....Characterisation of nanobubbles. Surprisingly, nano-sized bubbles have recently been found to exist in aqueous solutions. Classical theory tells us they should rapidly dissolve, yet they are stable for several days, a phenomenon which has only recently been explained. Despite this, nanobubbles are already used in cleaning processes and appear to have significant health benefits. They are being investigated in treatments for asthma and neurodegenerative diseases. In collaboration with a pharmaceutical company, the best means to produce and characterise nanobubbles will be investigated, as well as the conditions governing their stability. The project also aims to determine how the nanobubbles interact with surfaces in order to better control their properties and achieve a better understanding of these bubbles.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668421
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
A MEG-based cognitive neuroscience laboratory. At present there is no MEG system in Australia, whereas MEG systems are currently springing up in research institutions in many other countries across the globe. This project will enable Australia to remain at the forefront of research in the cognitive neurosciences, as well as provide training opportunities to Australian doctoral students and postdoctoral fellows in the use of MEG in research. Finally, the MEG laboratory will allow Australian resea ....A MEG-based cognitive neuroscience laboratory. At present there is no MEG system in Australia, whereas MEG systems are currently springing up in research institutions in many other countries across the globe. This project will enable Australia to remain at the forefront of research in the cognitive neurosciences, as well as provide training opportunities to Australian doctoral students and postdoctoral fellows in the use of MEG in research. Finally, the MEG laboratory will allow Australian researchers to fill important gaps in our understanding of several areas of cognitive neuroscience, including basic auditory and visual processing, the study of cognitive processing in schizophrenia and in children with dyslexia and/or specific language impairment.Read moreRead less
Towards efficient real-time generation of detectable musical macrostructure. Efficient generation of detectable large scale musical structure is needed for commercial audiovisual applications, and for creative music making. But computer mediation of music has focused elsewhere: on sound synthesis and sequencing, editing, mixing and notation. I will apply computational processes like the handling of chunks of genetic information in evolution, to generate large scale musical structure. I will con ....Towards efficient real-time generation of detectable musical macrostructure. Efficient generation of detectable large scale musical structure is needed for commercial audiovisual applications, and for creative music making. But computer mediation of music has focused elsewhere: on sound synthesis and sequencing, editing, mixing and notation. I will apply computational processes like the handling of chunks of genetic information in evolution, to generate large scale musical structure. I will control segmentation; framing of internal segments; spatialisation; and the overlaying of separable musical streams. Expert cognitive assessment of the resultant structures will be investigated, and theories of segmentation, streaming and their relationships with expression and affect developed and tested.Read moreRead less
A NOVEL MOUSE MODEL TO INVESTIGATE THE MECHANISMS OF VIRUS-INDUCED ARTHRITIS
Funder
National Health and Medical Research Council
Funding Amount
$336,000.00
Summary
We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators ( ....We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators (cytokines-chemokines) and antibodies is an overwhelming positive aspect of our physiological response to infection by microbes. Protection from disease by these immune compounds can happen naturally, or the body's ability to produce these factors can be exploited to our benefit via the administration of vaccines. However, these factors can also be detrimental to the host contributing to severe disease. For instance, work performed almost 40 years ago showed for the first time that under particular conditions, antibodies against viruses can enhance infection, instead of inhibiting infection as normally seen. In the intervening years work by scientists all over the world has associated antibody-dependent enhancement (ADE) of infection to many types of viruses; ADE is even thought to be a risk factor to serious disease with dengue virus, and has been shown in vitro for the AIDS virus and Ebola virus. We have recently discovered a molecular mechanism which explains how antibody enhances viral infection in vitro. In studies on immune cells infected with Ross River Virus (RRV) we found that infection helped by antibody resulted in the specific disruption to the production of cellular chemicals which are toxic to viruses. Are these mechanisms of antibody-enhanced infection also found in animals? Will such mode of infection cause enhanced disease and tissue pathology (arthritis) in animals?Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100210
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
In-vivo, high-resolution, whole animal imaging . The purchase of state-of-the-art live-animal imaging equipment for use by researchers at The Australian National University and The University of New South Wales. This equipment will aid the study of many aspects of normal biology and disease including cancer, inflammation, autoimmune diseases and blood vessel disorders.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less
A longitudinal study of the interaction of home and school language in three Aboriginal communities. The importance of language skills cannot be underestimated, and contribute to 'a healthy start to life'. In multilingual Indigenous communities, children must negotiate the complexities of different languages used for different purposes. This project will provide detailed insights into how children manage differences between home and school language, the kinds of problems they encounter when the ....A longitudinal study of the interaction of home and school language in three Aboriginal communities. The importance of language skills cannot be underestimated, and contribute to 'a healthy start to life'. In multilingual Indigenous communities, children must negotiate the complexities of different languages used for different purposes. This project will provide detailed insights into how children manage differences between home and school language, the kinds of problems they encounter when they enter the school system, and how their languages develop over the first four crucial years of school which provide the foundation for the children's future education. Their ability to manage the language of school underpins their ability to lead successful and engaged lives as adults. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100078
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Establishment of a comprehensive regional biophysical analysis facility. Interactions between molecules are needed for cells to function correctly. This facility will permit comprehensive molecular characterisation as well as research into the fundamentals of how molecules interact.