Designing new generation adjuvants for allergy and parasite vaccines. Allergy vaccines have the potential to provide a permanent cure against many allergic diseases, currently affecting 20-30 per cent of people in developed countries. This project will study how allergy vaccines work and how we can improve their effectiveness and safety.
Does phonological awareness help children learn to read? An almost universally-accepted view in the field of reading acquisition is that phonological awareness, or the ability to perceive and manipulate speech sounds, causes a child to be good at learning to read. We argue that, despite the voluminous literature on this issue, it has not been conclusively established that such a causal link exists. To do so requires a project, proposed here, in which completely pre-literate children are selec ....Does phonological awareness help children learn to read? An almost universally-accepted view in the field of reading acquisition is that phonological awareness, or the ability to perceive and manipulate speech sounds, causes a child to be good at learning to read. We argue that, despite the voluminous literature on this issue, it has not been conclusively established that such a causal link exists. To do so requires a project, proposed here, in which completely pre-literate children are selected, their phonological awareness measured, and its relationship with subsequent literacy acquisition followed. Settling this issue will have significant consequences for both theory and practice in reading acquisition and dyslexia.Read moreRead less
Dissecting the Parameters for the Generation of Cytotoxic T Lymphocyte Immunity. This project aims to identify mechanisms by which antigen-presenting cells, such as dendritic cells, prime CD8+ T cells to generate effector and memory populations at the molecular level. The specific intention is to identify reagents capable of licensing dendritic cells, and examine the down-stream gene products/pathways generated by these signals using microarray analyses. Such knowledge will provide new insight i ....Dissecting the Parameters for the Generation of Cytotoxic T Lymphocyte Immunity. This project aims to identify mechanisms by which antigen-presenting cells, such as dendritic cells, prime CD8+ T cells to generate effector and memory populations at the molecular level. The specific intention is to identify reagents capable of licensing dendritic cells, and examine the down-stream gene products/pathways generated by these signals using microarray analyses. Such knowledge will provide new insight into CTL generation by providing greater understanding of how multicellular systems function both at the cellular and molecular level.Read moreRead less
Imaging of immune responses to pathogens in vivo. This proposal represents an excellent opportunity for Australian science to participate in state-of-the-art research into the immune system and to be internationally competitive with the best researchers in the field. By combining advanced microscopy techniques with well developed biological models used by researchers at the University of Melbourne, this project will greatly improve our understanding of the dynamic interactions that occur betwee ....Imaging of immune responses to pathogens in vivo. This proposal represents an excellent opportunity for Australian science to participate in state-of-the-art research into the immune system and to be internationally competitive with the best researchers in the field. By combining advanced microscopy techniques with well developed biological models used by researchers at the University of Melbourne, this project will greatly improve our understanding of the dynamic interactions that occur between cells of the immune system during infectious diseases. The insight provided by this project will facilitate the design of better vaccines for protection against diseases, including influenza.Read moreRead less
Determinants of Audio-Visual effects in degraded and non-degraded speech. Seeing a speaker's face can affect the perception of their speech in a number of ways. This project proposes a detailed comparison of factors that affect Audio-Visual (AV) facilitation of degraded speech detection and identification. Detection-based tasks should be more sensitive to signal based correlations whereas identification-based effects more sensitive to complementary information. The significance of the current pr ....Determinants of Audio-Visual effects in degraded and non-degraded speech. Seeing a speaker's face can affect the perception of their speech in a number of ways. This project proposes a detailed comparison of factors that affect Audio-Visual (AV) facilitation of degraded speech detection and identification. Detection-based tasks should be more sensitive to signal based correlations whereas identification-based effects more sensitive to complementary information. The significance of the current proposal is that it offers both a strategy and a connected series of experiments for determining key behavioural constraints on AV speech integration. Understanding AV interactions will build links between neurophysiological processes and coherent perception and have important implications for AV application.Read moreRead less
Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encodi ....Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encoding and retrieval processes, the model can assess how changes in different sources of interference modulate performance through the trajectory of early development. Hierarchical Bayesian estimation aims to enable a simultaneous account of multiple tasks and support future deployment in applied contexts.Read moreRead less
CD1C-LIPID-REACTIVE T CELLS. The immune system patrols our body examining molecules such as proteins and lipids that signal whether or not everything is ok. While protein recognition by the immune system is well understood, our knowledge of the fundamental features of lipid detection is poor. This project will investigate the detection of lipid molecules that are presented to the immune system in association with a molecule known as CD1c. The aims are to understand: 1. The cells that respond to ....CD1C-LIPID-REACTIVE T CELLS. The immune system patrols our body examining molecules such as proteins and lipids that signal whether or not everything is ok. While protein recognition by the immune system is well understood, our knowledge of the fundamental features of lipid detection is poor. This project will investigate the detection of lipid molecules that are presented to the immune system in association with a molecule known as CD1c. The aims are to understand: 1. The cells that respond to these lipids; 2. The cellular receptors that bind to these lipids; 3. The types of lipids involved in this process. This work is essential for us to understand lipid-based immunology which is critical if we ultimately wish to harness this to improve human health.Read moreRead less
Stochastic, Neurally-Plausible Models for Selective Attention and Decision Making. An understanding of the basic cognitive processes involved in attention and decision making is the goal of international research effort in a number of disciplines. The benefits expected from such understanding include improvements in the diagnosis and treatment of a variety of cognitive deficits and improved occupational safety and efficiency in settings involving interaction with complex systems, such air traffi ....Stochastic, Neurally-Plausible Models for Selective Attention and Decision Making. An understanding of the basic cognitive processes involved in attention and decision making is the goal of international research effort in a number of disciplines. The benefits expected from such understanding include improvements in the diagnosis and treatment of a variety of cognitive deficits and improved occupational safety and efficiency in settings involving interaction with complex systems, such air traffic control, airline cockpits, motor vehicles, and process management. By developing mathematical models of these processes and the neural mechanisms that underlie them, this project will contribute to this understanding. It will also provide international postdoctoral opportunties for Australian-trained Ph.D. graduates.Read moreRead less
Understanding the relationship between child maltreatment and language competence: An evidential interviewing perspective. This research aims to develop the first comprehensive and controlled examination of the oral language profiles of maltreated children and how these impact performance in an investigative interview paradigm. This examination is essential for developing strategies for improving the elicitation of evidence from child abuse witnesses. By improving child witness evidence, this re ....Understanding the relationship between child maltreatment and language competence: An evidential interviewing perspective. This research aims to develop the first comprehensive and controlled examination of the oral language profiles of maltreated children and how these impact performance in an investigative interview paradigm. This examination is essential for developing strategies for improving the elicitation of evidence from child abuse witnesses. By improving child witness evidence, this research will improve the prosecution and conviction rates of child abuse offences, which will have a deterrent effect on potential offenders. Finally, this research will reduce the stress of witnesses involved in the legal process and provide better screening of children in need of specialised language intervention.Read moreRead less
An Integrated Theory of Attention and Decision Making. Biologically, the fundamental computational task carried out by the human brain is the translation of perception into action. To perform this translation, attentional processes select relevant stimuli from the environment and decision processes then identify the selected stimuli. This project develops an integrated theory of attention and decision making in simple visual tasks, which will help us understand how these tasks are carried out i ....An Integrated Theory of Attention and Decision Making. Biologically, the fundamental computational task carried out by the human brain is the translation of perception into action. To perform this translation, attentional processes select relevant stimuli from the environment and decision processes then identify the selected stimuli. This project develops an integrated theory of attention and decision making in simple visual tasks, which will help us understand how these tasks are carried out in the brain. Understanding how these tasks are performed biologically will aid in the design of autonomous information-gathering and decision-making agents whose actions simulate human behaviour. Read moreRead less