Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100229
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
A prototype Scanning Helium Atom Microscope (SHeM) for soft materials. The scanning helium atom microscope (SHeM) has been a tantalising prospect since the birth of quantum physics. The SHeM would have unparalleled resolution and would be completely non-damaging; potentially revolutionising the imaging of soft delicate materials. This project will develop the first SHeM instrument in Australia to study soft matter.
Phonon based condensed matter imaging. This project will exploit observations of phonon-based chemical contrast in the SHeM to determine the physics that underpins the imaging mechanism and use them to probe vibrational processes in condensed matter imaging. Imaging is an essential tool for the discovery, application and fabrication of new materials, structures and devices. However, many delicate structures are irrevocably degraded and changed when imaged using conventional microscopy. This team ....Phonon based condensed matter imaging. This project will exploit observations of phonon-based chemical contrast in the SHeM to determine the physics that underpins the imaging mechanism and use them to probe vibrational processes in condensed matter imaging. Imaging is an essential tool for the discovery, application and fabrication of new materials, structures and devices. However, many delicate structures are irrevocably degraded and changed when imaged using conventional microscopy. This team recently invented the scanning helium atom microscope (SHeM), which can image surfaces non-destructively with nanoscale resolution. They will use the SHeM to determine the new fundamental physics that underpins the imaging mechanism. Outcomes include turning SHeM into a tool that materials and biological scientists can use in laboratories worldwide.Read moreRead less
3D integrated crystalline UV optical lens-fiber couplers for astronomy. This project aims to create micro-optics for astronomical and bio medical applications by 3D sculpturing them out of crystals by ultra-short pulse lasers. This project will introduce a new 3D fabrication approach of optical probes which have self-aligned micro-optical elements and optical fibres for a wide spectral range and with high quality optical surfaces. Expected outcomes of this project include building new capabiliti ....3D integrated crystalline UV optical lens-fiber couplers for astronomy. This project aims to create micro-optics for astronomical and bio medical applications by 3D sculpturing them out of crystals by ultra-short pulse lasers. This project will introduce a new 3D fabrication approach of optical probes which have self-aligned micro-optical elements and optical fibres for a wide spectral range and with high quality optical surfaces. Expected outcomes of this project include building new capabilities in micro-optical probes for industrial environments, establishing new solutions for international astronomy partners, and developing new techniques to image through optical fibres. This should provide significant benefits by improving astronomical instrumentation and also lead to less invasive endoscopy.Read moreRead less
Chemical mapping of materials at the atomic scale. This project will develop a method for measuring the chemical composition of technologically important nanomaterials. This capability will provide Australian scientists with an advanced method for the characterisation of materials and will help them to develop new and better materials for future applications.
Microfluidic Separation Science: Innovative Technology for Characterising Complex Chemical Systems. At present there is a need for fast and detailed chemical analysis of complex samples, such as those important to biomedical diagnostics and forensic science. Innovative technology will be developed here in order to reduce analysis time whilst maintaining the integrity of the chemical information contained within the sample. This step change in separation science will directly aid biomedical diagn ....Microfluidic Separation Science: Innovative Technology for Characterising Complex Chemical Systems. At present there is a need for fast and detailed chemical analysis of complex samples, such as those important to biomedical diagnostics and forensic science. Innovative technology will be developed here in order to reduce analysis time whilst maintaining the integrity of the chemical information contained within the sample. This step change in separation science will directly aid biomedical diagnostics, forensic sample determination and industrial process monitoring through decreased analysis time with an increase in the chemical information gained. By performing chemical separations on a microfluidic scale a reduction in both the cost of analysis and impact of solvent waste on the environment will be achieved.Read moreRead less
Creating a non-invasive window into the mind. This project aims to create better tools to study the human mind. This project expects to generate new knowledge that can be used to non-invasively image neuronal activity. Expected outcomes include the development of unique new Magnetic Resonance Imaging (MRI) instruments to study neuronal activity in both highly controlled laboratory conditions and in humans, with the spatial and temporal resolution needed to study the neuronal circuitry that drive ....Creating a non-invasive window into the mind. This project aims to create better tools to study the human mind. This project expects to generate new knowledge that can be used to non-invasively image neuronal activity. Expected outcomes include the development of unique new Magnetic Resonance Imaging (MRI) instruments to study neuronal activity in both highly controlled laboratory conditions and in humans, with the spatial and temporal resolution needed to study the neuronal circuitry that drives low and high-level brain functions, i.e., creating a window into the mind. In the future, outcomes from this study could improve our understanding of mental disorders, advance computer brain interface technology, and inspire the next paradigm shift in artificial intelligence.Read moreRead less
X-ray Ghost Imaging and Tomography. This project aims to achieve safer, faster, and cheaper 3D X-ray imaging through a technique known as ghost imaging. X-ray imaging provides valuable information about internal structures, however, X-rays are carcinogenic and exposure (or dose) should be limited. Ghost imaging is an unconventional technique developed with visible light that has many potential benefits over conventional imaging. This research group are world leaders in ghost imaging and expect t ....X-ray Ghost Imaging and Tomography. This project aims to achieve safer, faster, and cheaper 3D X-ray imaging through a technique known as ghost imaging. X-ray imaging provides valuable information about internal structures, however, X-rays are carcinogenic and exposure (or dose) should be limited. Ghost imaging is an unconventional technique developed with visible light that has many potential benefits over conventional imaging. This research group are world leaders in ghost imaging and expect to develop software and hardware techniques to realise its potential and extend it to ghost tomography. The focus of this project is on reducing cancer risk in medical imaging, and allowing real-time quality control for 3D printing in safety-critical industries such as aerospace.Read moreRead less
A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of ....A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of interest to capture the miRNA. Application of a magnetic field allows the levels of miRNA to be detected electrochemically. The expected outcome is a commercialisable biosensor for miRNA both as a diagnostic early detection device and a prognostic device for a range of miRNA biomarkers.Read moreRead less
Precision tests of fundamental physics at the electroweak unification scale. The project aims to advance novel precision frequency generation and measurement techniques beyond the present state of the art, through the implementation of sapphire and quartz bulk acoustic wave resonator and related technology at low temperature. The project plans to apply this technological advancement to extremely sensitive tests of General Relativity able to probe suppressed effects emanating from the Planck scal ....Precision tests of fundamental physics at the electroweak unification scale. The project aims to advance novel precision frequency generation and measurement techniques beyond the present state of the art, through the implementation of sapphire and quartz bulk acoustic wave resonator and related technology at low temperature. The project plans to apply this technological advancement to extremely sensitive tests of General Relativity able to probe suppressed effects emanating from the Planck scale. Such tests include new tests of Lorentz invariance violations of photons and phonons, tests of fundamental constant invariance and other tests of fundamental physics. Results could lead to the discovery of the correct theory of quantum gravity, a major unsolved problem in contemporary physics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100074
Funder
Australian Research Council
Funding Amount
$418,210.00
Summary
Nanoscale laser cooling in physiological environment. By developing fluorescence pattern-based 3D motion-detection technology in optical tweezers, this project aims to reveal how to achieve nanoscale laser cooling in physiological media. It plans to discover new mechanisms of cooling associated with surface phonons and energy looping in optically trapped lanthanide-doped nanoparticles. Key expected outcomes are technology and a toolset to create interaction between cooled nanoscale objects and b ....Nanoscale laser cooling in physiological environment. By developing fluorescence pattern-based 3D motion-detection technology in optical tweezers, this project aims to reveal how to achieve nanoscale laser cooling in physiological media. It plans to discover new mechanisms of cooling associated with surface phonons and energy looping in optically trapped lanthanide-doped nanoparticles. Key expected outcomes are technology and a toolset to create interaction between cooled nanoscale objects and biological samples. These are expected to create a research area of biological laser refrigeration, enabling intracellular organelles cooling, nanoscale membrane disruption and high sensitivity force-sensing for integrin study for use in single-molecule biophysics and multimodality subcellular sensing.Read moreRead less