Development Of A New Surgical-guidance Tool For Intra-operative Tumour Margin Assessment In Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$557,982.00
Summary
One third of breast cancer patients undergoing breast conserving surgery have insufficient tissue removed, resulting in an increased risk of recurrence. We have developed a high resolution optical imaging probe with the potential to detect small areas of cancer. It could be used to help guide the surgeon to remove all cancerous tissue from the patient. This grant will allow us to develop the probe to a stage that it can be used during surgery, and perform the world’s first clinical scans.
Development Of Microscope-in-a-needle Devices For Improved Clinical Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$327,746.00
Summary
We have developed a new high-resolution optical imaging technology. The unique aspect of our research has been to redesign the imaging probe, miniaturising it to a few hundred microns in diameter, and encase it in a hypodermic needle – a ‘microscope-in-a-needle’. We are developing specific imaging probes to aid in the assessment of lung disease; the diagnosis of liver disease; and integrated into a brain biopsy needle to enable safer brain biopsies.
Advances in positron emission tomography now allow specific pathological features of many brain diseases such as Alzheimer's disease to be measured with a brain scan during life. This Fellowship will assist Professor Rowe and his team in their world leading work on new PET scanning techniques to improve diagnosis and assist the development of treatment for Alzheimer's and other degenerative diseases of the brain.
Improving Human FMRI Through Modeling And Imaging Microvascular Dynamics
Funder
National Health and Medical Research Council
Funding Amount
$486,144.00
Summary
In this project we aim to establish a reliable vascular baseline to improve mapping of both small-scale functional architecture and large-scale brain networks in functional human brain mapping using MRI. By mapping the grey matter vasculature with high detail in both humans and animals, and by computing and matching of these atlases across species we will be able to validate this approach in vivo to confirm the better spatial specificity of the newly developed approach.
Non-invasive Near-infrared Optical Imaging Of Neurodegeneration
Funder
National Health and Medical Research Council
Funding Amount
$312,033.00
Summary
Dementia currently affects over 240,000 Australians with an increasing health cost. A common cause of dementia occurs when proteins in the brain form deposits and brain cells degenerate and die. This project will develop a novel medical imaging method that will facilitate the detection of dying brain cells. This will enable a better understanding of the causes of cell death and the opportunity to identify the best time for meaningful therapeutic intervention.
Single Shot X-ray Tomography For Real-Time Functional X-ray Imaging
Funder
National Health and Medical Research Council
Funding Amount
$322,641.00
Summary
Computed Tomography (CT) scanners produce three-dimensional images of vital organs that cannot be obtained by conventional two-dimensional (single projection) x-ray radiographs. However, the radiation exposure is hundreds of times higher than conventional radiography. We will develop the world’s first CT scanner that uses no more radiation than a single conventional x-ray image that will provide four-dimensional reconstructions of a patient’s moving internal organs.
Micro-elastography - A New Tool For Microscopic Intraoperative Tumour Margin Assessment In Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$195,956.00
Summary
In breast cancer surgery, it is vital to completely remove the entire tumour. Unfortunately, in 30% of breast-conserving surgeries, re-excision is required because microscopic analysis after the surgery indicated some tumour had been missed. This has traumatic consequences for the patient and places a huge economic burden on the healthcare system. Using micro-elastography, we will enable the surgeon to detect small regions of tumour during the initial surgery. This probe may significantly reduce ....In breast cancer surgery, it is vital to completely remove the entire tumour. Unfortunately, in 30% of breast-conserving surgeries, re-excision is required because microscopic analysis after the surgery indicated some tumour had been missed. This has traumatic consequences for the patient and places a huge economic burden on the healthcare system. Using micro-elastography, we will enable the surgeon to detect small regions of tumour during the initial surgery. This probe may significantly reduce the number of additional surgeries required.Read moreRead less
My aim is to use advanced Neuroimaging to further our understanding of the pathophysiology of brain disorders, in particular Epilepsy, but also Sleep disorders, Schizophrenia, the Dementias. In the case of my main research interest (Epilepsy) it is to red
We have previously made the most widely used animal brain atlas in the world. This atlas based on stained histological sections of the rat brain. In recent years, advances in MRI have made it possible to generate images of the rat brain at very high resolution. We have obtained a very high quality MRI image set from colleagues in Duke University in the USA, and we have begun to map these images in great detail, using our histological atlas as a guide.