Discovery Early Career Researcher Award - Grant ID: DE240101035
Funder
Australian Research Council
Funding Amount
$450,760.00
Summary
Charting the brain's wiring over the human lifespan. This project aims to produce a large-scale model of brain wiring over the human lifespan by utilising normative modelling approaches on state-of-the-art diffusion magnetic resonance imaging (diffusion MRI) data. This project expects to generate new understanding of how the brain's connections change with age in healthy individuals. Expected outcomes of this project include a reference chart for healthy brain wiring, and major advances in diffu ....Charting the brain's wiring over the human lifespan. This project aims to produce a large-scale model of brain wiring over the human lifespan by utilising normative modelling approaches on state-of-the-art diffusion magnetic resonance imaging (diffusion MRI) data. This project expects to generate new understanding of how the brain's connections change with age in healthy individuals. Expected outcomes of this project include a reference chart for healthy brain wiring, and major advances in diffusion MRI data harmonisation approaches. This should provide significant benefits for the translation of advanced diffusion MRI methods, as normative charts for brain wiring will be made broadly available. This could have broad implications for interpreting individual diffusion MRI scans in future.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101222
Funder
Australian Research Council
Funding Amount
$371,392.00
Summary
The development of novel magnetic resonance imaging methods to investigate brain structure and function. Magnetic resonance imaging (MRI) is a non-invasive method that has revolutionised neuroscience. The goal of this project is to develop state-of-the-art MRI analysis methods that reveal new information about brain structure and function. These novel neuroimaging tools will be instrumental in furthering our understanding of how the brain works.
Advanced magnetic resonance imaging methods for the characterisation of brain structure and function. Magnetic resonance imaging (MRI) is a non-invasive method that has revolutionised the development of neuroscience and neurology. The goal of this project is to develop advanced MRI methods for the study of brain structure and function which will be applied to the investigation of epilepsy and stroke.
Prediction of tissue fate and functional outcome in acute ischemic stroke with advanced imaging analysis - experimental validation and translational studies. Stroke is predominantly a disease of ageing and the commonest cause of adult disability. In Australia, 55,000 people have a stroke each year (>80% are over age 65). The total number of strokes per year worldwide will rise 60% within the next two decades as the proportion of elderly in our population increases. This research will improve bra ....Prediction of tissue fate and functional outcome in acute ischemic stroke with advanced imaging analysis - experimental validation and translational studies. Stroke is predominantly a disease of ageing and the commonest cause of adult disability. In Australia, 55,000 people have a stroke each year (>80% are over age 65). The total number of strokes per year worldwide will rise 60% within the next two decades as the proportion of elderly in our population increases. This research will improve brain imaging selection for acute stroke therapies in clinical trials and practice. Better acute stroke therapies limit the size of brain damage from stroke and reduce long-term disability. Thus, this research will directly translate into allowing our population to 'age well and productively'.Read moreRead less
Visualising Retinal Microglia as a Window into Brain Inflammation. This project aims to use the unique autofluorescence signature of immune cells, microglia, imaged in the retina, as an index of brain inflammation. This project expects to provide the fundamental knowledge to allow us to image microglia non-invasively and identify the presence of brain inflammation without needing to access the brain-proper. Expected outcomes include full characterisation of microglial autofluorescence in the ret ....Visualising Retinal Microglia as a Window into Brain Inflammation. This project aims to use the unique autofluorescence signature of immune cells, microglia, imaged in the retina, as an index of brain inflammation. This project expects to provide the fundamental knowledge to allow us to image microglia non-invasively and identify the presence of brain inflammation without needing to access the brain-proper. Expected outcomes include full characterisation of microglial autofluorescence in the retina and how it relates to brain inflammation. This should provide significant downstream benefits for the detection of inflammatory brain disease well before visible symptoms develop with substantial benefit for livestock, pets, zoo and conservation animals, as well as research knowledge. Read moreRead less
Brain connectome: from synapse, large-scale network to behaviour. This project aims to investigate how behaviour shapes the large-scale network synchrony by determination of task-specific networks using whole-brain resting-state functional Magnetic Resonance Imaging (MRI) and its relationship with synaptic plasticity. Enhanced synaptic connectivity has been suggested as a mechanism of memory but the system-level circuit dynamics in memory process are not clear. The outcome is anticipated to brid ....Brain connectome: from synapse, large-scale network to behaviour. This project aims to investigate how behaviour shapes the large-scale network synchrony by determination of task-specific networks using whole-brain resting-state functional Magnetic Resonance Imaging (MRI) and its relationship with synaptic plasticity. Enhanced synaptic connectivity has been suggested as a mechanism of memory but the system-level circuit dynamics in memory process are not clear. The outcome is anticipated to bridge the knowledge gap between brain and behaviour.Read moreRead less
Decoding the brain network of memory formation. This project aims to uncover how the brain network supports the formation of long-lasting memory using cutting-edge imaging, intervention and computational modelling. The project is anticipated to generate new knowledge of the neural activity and circuitry that facilitate memory formation, and targets for modulating network activity and behaviour. This will have significant benefits for neuroscience, engineering and imaging, as well as future appli ....Decoding the brain network of memory formation. This project aims to uncover how the brain network supports the formation of long-lasting memory using cutting-edge imaging, intervention and computational modelling. The project is anticipated to generate new knowledge of the neural activity and circuitry that facilitate memory formation, and targets for modulating network activity and behaviour. This will have significant benefits for neuroscience, engineering and imaging, as well as future applications in humans with technology for detecting, predicting and modulating cognitive performance.Read moreRead less