Immune Regulation Of Colitis And Associated Cancer
Funder
National Health and Medical Research Council
Funding Amount
$646,995.00
Summary
Inflammatory bowel disease is a debilitating condition that can significantly increase the likelihood of developing colon cancer. There are many different cellular pathways that lead to this inflammation, but we have uncovered a key signal that can prevent it from occurring. Specifically, we have identified how this signal increases a new type of suppressive cell that fights inflammation in the colon and can also stop this leading cancer.
Role For Dipeptidyl Peptidase-IV In The Innate Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$302,123.00
Summary
The innate immune system is the bodyÍs first line of defence in fighting off infections by invading organisms. An inappropriate innate immune response can lead to the development of several inflammatory conditions such as inflammatory bowel disease. A malfunctioning innate immune response has been identified in children with IBD. This project will determine the role of a unique enzyme called DPIV in the development of innate immune responses and its potential as a therapeutic target for IBD.
Regulation Of Immune And Inflammatory Responses By Short Chain Fatty Acids And GPR43
Funder
National Health and Medical Research Council
Funding Amount
$549,092.00
Summary
Innate immune mechanisms provide essential signals that determine the outcome of immune responses. The identity of these innate mechanisms may provide opportunities for manipulating immune responses, or controlling inflammatory responses. This proposal centers around a new and little-studied receptor, GPR43, which binds products of bacterial metabolism. This molecular pathway may explain how diet affect immune responses.
Inhibitors Of Class II HDACs In Inflammatory And Metabolic Disease
Funder
National Health and Medical Research Council
Funding Amount
$615,774.00
Summary
Inflammatory diseases such as arthritis and inflammatory bowel syndrome are major social and economic burdens on Australian communities. Obesity, diabetes and cardiovascular disease are also now widely viewed as inflammatory diseases. New specialised types of anti-inflammatory drugs are urgently needed to treat such diseases. This project proposes to create new classes of anti-inflammatory drugs by altering anti-cancer drugs called histone deacetylase inhibitors.