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Australian State/Territory : QLD
Research Topic : INTRACELLULAR RECORD
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  • Funded Activity

    Achieving Better Mental Health For Maltreated Children: Translating Population Data Into Policy

    Funder
    National Health and Medical Research Council
    Funding Amount
    $522,706.00
    Summary
    This project uses linked population data to determine (a) the earliest indicators of risk of harm, and (b) mental health outcomes and health-care costs associated with children receiving child protection services, in partnership with the NSW department of Family and Community Services. The findings will ensure timely and effective responses to the most vulnerable children to mitigate adverse mental health and other outcomes associated with early life adversity.
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    Developmental Schizotypy In The General Population: Early Risk Factors And Predictive Utility.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $830,952.00
    Summary
    This study will determine early childhood risk factors for psychosis-proneness in children aged 11 years, and emerging signs and symptoms of mental health disorders of these children, using population data from the NSW Child Development Study. Determining risk for psychosis as early as possible in the life course will enable the provision of preventative interventions to children at critical points in development.
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    Funded Activity

    Fighting Infection: Exploiting Host-pathogen Interactions

    Funder
    National Health and Medical Research Council
    Funding Amount
    $9,550,768.00
    Summary
    This program will investigate the strategies used by pathogenic bacteria to cause human diseases. The research will focus on how bacteria initiate infections, how they invade, cause cell and tissue damage and respond to their human host. It will also examine how the host’s innate immune system interacts with these bacteria. The results will provide new insights into host-pathogen interactions and reveal new targets for the development of novel antibacterial drugs and vaccines.
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    Funded Activity

    Mechanism Of Action Of Sec1p-like Proteins In Membrane Trafficking

    Funder
    National Health and Medical Research Council
    Funding Amount
    $234,936.00
    Summary
    One of the most important evolutionary changes that has occurred is the development of intracellular compartments. All eukaryotic cells possess numerous membrane-encased structures which provide the basis for intracellular specialisation. For example, in order to degrade unwanted components cells have developed degradative enzymes. It is vital for the cell that these enzymes are sequestered away from other cellular components to avoid destruction of valuable molecules. In addition, the cell has .... One of the most important evolutionary changes that has occurred is the development of intracellular compartments. All eukaryotic cells possess numerous membrane-encased structures which provide the basis for intracellular specialisation. For example, in order to degrade unwanted components cells have developed degradative enzymes. It is vital for the cell that these enzymes are sequestered away from other cellular components to avoid destruction of valuable molecules. In addition, the cell has developed a complex assembly line of modifications that are added to proteins in a specific order as they travel to their final destination within the cell. This necessitates the accurate passage of molecules between compartments, a process known as vesicle transport. To orchestrate the complex network of vesicular transport steps between all of the various intracellular compartments it is necessary to employ complex machinery to guide and check that these steps occur with high fidelity. The goal of our research proposal is to define the function of one of the molecules involved in this control process, the so-called Sec1p proteins. The strength of our proposal lies in the diversity of our approach. We intend to explore the molecular advantages of a relatively simple eukaryotic organism, a yeast cell, and apply the findings obtained from this cell to a more complex but highly related vesicular transport process; that of the insulin-regulated movement of a glucose transporter in mammalian fat and muscle cells. While we intend to apply our findings to the treatment of patients with diabetes, it is our ultimate goal to be able to learn more about this fundamental cell biological process so that we can apply our knowledge to understanding many different disease states.
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    Funded Activity

    Discovery Projects - Grant ID: DP0346109

    Funder
    Australian Research Council
    Funding Amount
    $407,000.00
    Summary
    Frank Hurley: The Making of a Modern Cultural Icon. I propose to write a book about Frank Hurley (1885-1962) dealing comprehensively for the first time with his photography, cinematography and writing from the perspective of the new humanities disciplines, and to make an original argument about the significance of his career for modern Australian culture in its international contexts. The book will exemplify a new theory and practice of interdisciplinary research. A second objective is to publis .... Frank Hurley: The Making of a Modern Cultural Icon. I propose to write a book about Frank Hurley (1885-1962) dealing comprehensively for the first time with his photography, cinematography and writing from the perspective of the new humanities disciplines, and to make an original argument about the significance of his career for modern Australian culture in its international contexts. The book will exemplify a new theory and practice of interdisciplinary research. A second objective is to publish an edition of Hurley's diaries. Melbourne University Press have formally expressed interest in both books. The text of the diaries will also be made available on the internet by the Mitchell Library and National Library of Australia.
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    Funded Activity

    Discovery Projects - Grant ID: DP0451875

    Funder
    Australian Research Council
    Funding Amount
    $87,000.00
    Summary
    Mujaku Dochu (1653-1744) and the hidden foundations of modern Zen scholarship. Mujaku Dochu (1653-1744), a polymath Japanese monk of the Rinzai Zen Buddhist school was the major, but unacknowledged, founder of modern Zen scholarship. He established many critical editions, compiled dictionaries of colloquial Chinese terminology used in Zen, and wrote numerous commentaries or glosses to key Zen texts. He wrote the monastic regulations still used in Rinzai monasteries, and advised Hakuin (1685-17 .... Mujaku Dochu (1653-1744) and the hidden foundations of modern Zen scholarship. Mujaku Dochu (1653-1744), a polymath Japanese monk of the Rinzai Zen Buddhist school was the major, but unacknowledged, founder of modern Zen scholarship. He established many critical editions, compiled dictionaries of colloquial Chinese terminology used in Zen, and wrote numerous commentaries or glosses to key Zen texts. He wrote the monastic regulations still used in Rinzai monasteries, and advised Hakuin (1685-1768), the restorer of all modern Rinzai. This study will investigate Dochu's methodologies, his scholarly predecessors, and his influences on contemporaries and on modern Zen scholarship by examining his analyses of Chinese vocabulary, his lexicography and text criticism.
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    Funded Activity

    Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347049

    Funder
    Australian Research Council
    Funding Amount
    $403,000.00
    Summary
    Building Australian Literary Knowledge Infrastructure. The primary goal of AustLit: the Australian Literature Gateway is to facilitate and encourage research in, and teaching of, the nation's creative and critical literature. AustLit's innovative world class resource discovery service utilises best practice techniques in information management and knowledge sharing. In 2003, AustLit will develop new technical services and important new content to meet the defined needs of a wide range of educati .... Building Australian Literary Knowledge Infrastructure. The primary goal of AustLit: the Australian Literature Gateway is to facilitate and encourage research in, and teaching of, the nation's creative and critical literature. AustLit's innovative world class resource discovery service utilises best practice techniques in information management and knowledge sharing. In 2003, AustLit will develop new technical services and important new content to meet the defined needs of a wide range of education and information consumers in the area. AustLit provides the foundation for a subject specific digital library that will retain and expand its usefulness into the future.
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    Funded Activity

    Discovery Projects - Grant ID: DP0771376

    Funder
    Australian Research Council
    Funding Amount
    $256,138.00
    Summary
    America Publishes Australia: Australian Books and American Publishers, 1890-2005. Research into the commercial and cultural links between American publishers and Australian writers will reveal a new dimension of the nation's relationship to its most important cultural trading partner. By focusing on a neglected area of Australian publishing history, the project will also contribute significantly to our understanding of the changing circumstances within which Australian writers and publishers hav .... America Publishes Australia: Australian Books and American Publishers, 1890-2005. Research into the commercial and cultural links between American publishers and Australian writers will reveal a new dimension of the nation's relationship to its most important cultural trading partner. By focusing on a neglected area of Australian publishing history, the project will also contribute significantly to our understanding of the changing circumstances within which Australian writers and publishers have worked. Publishing remains under-researched compared to other cultural industries in Australia, despite its significance both culturally and economically.
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    Funded Activity

    Reliability Of An Online Geriatric Assessment Procedure

    Funder
    National Health and Medical Research Council
    Funding Amount
    $343,822.00
    Summary
    This study will examine the reliability, safety and cost of a novel new method of providing geriatrician assessment to older people in hospital. Nurses consult with the patient and enter their findings on a web-based software system that enables the geriatrician to review, report and make recommendations over the internet.
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    Funded Activity

    Special Research Initiatives - Grant ID: SR0354701

    Funder
    Australian Research Council
    Funding Amount
    $10,000.00
    Summary
    The Print Cultures Network: Print Culture and National Culture in a Globalised Economy. This Network will bring together researchers from a range of disciplinary/professional backgrounds and specialists in the deployment of frontier technologies in information management. Building on expertise in literary history, publishing, editing and bibliographical studies the Network will establish collaborations between researchers in the emerging interdisciplinary fields of book history, print culture, p .... The Print Cultures Network: Print Culture and National Culture in a Globalised Economy. This Network will bring together researchers from a range of disciplinary/professional backgrounds and specialists in the deployment of frontier technologies in information management. Building on expertise in literary history, publishing, editing and bibliographical studies the Network will establish collaborations between researchers in the emerging interdisciplinary fields of book history, print culture, publishing studies and new generation information management. Its connective thematic will be the dynamics between print culture/the print economy, national cultures and global structures of production and consumption. Its unique feature will be its generative interaction with the multi-institutional collaboration already existing in the AustLit Gateway - (www.austlit.edu.au).
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