Surface tension-confined microfluidics: moving towards a flexible platform for diagnostics. The point-of-care industry is poised to fulfil the international need for effective and mobile diagnostics tools; however current strategies are restricting this from becoming a reality. Surface tension-confined microfluidics provide an opportunity to meet the requirements necessary for flexible platform for point-of-care devices.
Engineering functional nerves using microtailored culture systems. The aim of this work is to develop new culture systems for developing and growing nerves outside of the body. The project will generate knowledge and engineering technology for production of neural implants suitable for medical applications. The availability of engineered nerve grafts to repair neural injuries will improve patient health outcomes.
Elliptical nozzles: the shape of silence? This project aims to leverage the aeroacoustic properties of elliptical nozzle geometries to significantly reduce installed jet noise. This project expects to generate new knowledge regarding methods to reduce installed jet noise, a serious problem for the aerospace industry. Regulatory constraints inhibit the implementation of efficiency-increasing configurations but still fail to eliminate public health impacts. Expected outcomes include a set of tools ....Elliptical nozzles: the shape of silence? This project aims to leverage the aeroacoustic properties of elliptical nozzle geometries to significantly reduce installed jet noise. This project expects to generate new knowledge regarding methods to reduce installed jet noise, a serious problem for the aerospace industry. Regulatory constraints inhibit the implementation of efficiency-increasing configurations but still fail to eliminate public health impacts. Expected outcomes include a set of tools for optimizing nozzle designs capable of significantly reducing installed jet noise. This will provide significant benefits, as jet noise is a serious health issue for the Australian public. This project represents an opportunity to reduce its impact while improving fuel efficiency.Read moreRead less
New generation microfluidic devices using light responsive hydrogels. This project aims to develop a new way of fabricating microfluidic devices using light-degradable hydrogels as its core element. This approach would allow researchers to rapidly construct and modify microfluidic devices within their own laboratories, without the need for specialised clean rooms or expensive equipment. The versatility of the microfluidic device is designed to be demonstrated by the manufacture of mature T cells ....New generation microfluidic devices using light responsive hydrogels. This project aims to develop a new way of fabricating microfluidic devices using light-degradable hydrogels as its core element. This approach would allow researchers to rapidly construct and modify microfluidic devices within their own laboratories, without the need for specialised clean rooms or expensive equipment. The versatility of the microfluidic device is designed to be demonstrated by the manufacture of mature T cells, which continues to be a major challenge in stem cell science and which could have fundamental biological and commercial significance.Read moreRead less
Design of Microstructures for Materials and Composites with Desired Functional Properties. The creation of new and advanced materials and composites will underpin the growth in many industrial and economic activities in Australia. This project will meet the substantial scientific and technological challenges in exploring and finding optimal microstructures for materials and composites with desired functional properties. The proposed research will significantly extend a topological optimization t ....Design of Microstructures for Materials and Composites with Desired Functional Properties. The creation of new and advanced materials and composites will underpin the growth in many industrial and economic activities in Australia. This project will meet the substantial scientific and technological challenges in exploring and finding optimal microstructures for materials and composites with desired functional properties. The proposed research will significantly extend a topological optimization technique known as ESO/BESO - an Australian initiative that has earned a widespread international recognition. Its further development and applications will enable the Australian researchers and engineers to maintain and enhance the national capacity to exploit a niche market in the design of novel materials and composites.Read moreRead less
Biodegradable immuno-therapeutic nanoparticles. The national benefit relates directly to Promoting and Maintaining Good Health through preventative healthcare as this project will develop a new vaccine delivery platform that will contribute to preventing a host of diseases such as viral infections and malaria. The health benefits of better vaccines directly enhance a Healthy Start to Life and Ageing Well. This area of nanoparticle therapies is a global 'hot spot' and this multi-disciplinary team ....Biodegradable immuno-therapeutic nanoparticles. The national benefit relates directly to Promoting and Maintaining Good Health through preventative healthcare as this project will develop a new vaccine delivery platform that will contribute to preventing a host of diseases such as viral infections and malaria. The health benefits of better vaccines directly enhance a Healthy Start to Life and Ageing Well. This area of nanoparticle therapies is a global 'hot spot' and this multi-disciplinary team could make huge and rapid progressions in this area of therapeutics. New intellectual property in the area of therapeutic particle production is the cornerstone of this project and could deliver lasting economic benefits through the creation of new health products and patents.Read moreRead less
The structure of turbulent boundary layers. This research has an enormous impact in many fields of engineering - for example, in aeronautical, mechanical, chemical, meteorological and biomedical engineering. The resulting energy and economic savings and the reduction in atmospheric pollution and greenhouse gasses will ultimately impact on areas such as global climatic change and the energy sustainability of our urban environment, thus influencing the well-being of all people living on this plan ....The structure of turbulent boundary layers. This research has an enormous impact in many fields of engineering - for example, in aeronautical, mechanical, chemical, meteorological and biomedical engineering. The resulting energy and economic savings and the reduction in atmospheric pollution and greenhouse gasses will ultimately impact on areas such as global climatic change and the energy sustainability of our urban environment, thus influencing the well-being of all people living on this planet. This research project will result in technological advancement and provide important training for future generations of researchers. This will entrench the Australian engineering and scientific community as world leaders in this area of scientific research.Read moreRead less
The structure of turbulence at high Reynolds numbers. The aim of this project is to gain a physical understanding of the process of turbulence in fluid motion, focusing on boundary layers adjacent to the surface of bodies, such as submarines and turbines. As turbulence is of fundamental importance in many engineering tasks, developing our understanding of the mechanisms involved will lead to progress in many areas. For example, accurate prediction of drag on vehicles, aircraft and ships, result ....The structure of turbulence at high Reynolds numbers. The aim of this project is to gain a physical understanding of the process of turbulence in fluid motion, focusing on boundary layers adjacent to the surface of bodies, such as submarines and turbines. As turbulence is of fundamental importance in many engineering tasks, developing our understanding of the mechanisms involved will lead to progress in many areas. For example, accurate prediction of drag on vehicles, aircraft and ships, resulting in reductions in fuel consumption. The wind tunnel used in this project is the largest of its type in the world, enabling pioneering experiments to be undertaken which will extend our understanding of the physics of turbulence for applied flows.
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Genesis and evolution of coherent structures in wall-bounded turbulence. This project aims to capture conditions responsible for the generation of the coherent structures that are formed in wall-bounded turbulent flows, through the use of variational data assimilation and adjoint-based optimisation techniques. The project is expected to provide knowledge and intellectual property that is essential for the accurate modelling and prediction of the interaction between the ground-level activities li ....Genesis and evolution of coherent structures in wall-bounded turbulence. This project aims to capture conditions responsible for the generation of the coherent structures that are formed in wall-bounded turbulent flows, through the use of variational data assimilation and adjoint-based optimisation techniques. The project is expected to provide knowledge and intellectual property that is essential for the accurate modelling and prediction of the interaction between the ground-level activities like pollutant emissions and the atmosphere and the flow over vehicles through pipes, turbines and compressors. This project will provide benefits such as reducing the risk in environmental and commercial design and decision making and will facilitate new opportunities for the commercial development of devices to reduce drag and enhance mixing and heat transfer via the direct manipulation of coherent structures.Read moreRead less
Understanding turbulent heat transfer with practical surface conditions. Heat transfer dictates the efficiency of energy and transport systems such as gas turbines, high-speed generators and turbochargers. These are among many applications where heat transfer involves turbulent fluid flow over solid surfaces, but where poor understanding of surface conditions leads to dubious models, suboptimal designs and cost penalties. This project therefore aims to advance our fundamental understanding of he ....Understanding turbulent heat transfer with practical surface conditions. Heat transfer dictates the efficiency of energy and transport systems such as gas turbines, high-speed generators and turbochargers. These are among many applications where heat transfer involves turbulent fluid flow over solid surfaces, but where poor understanding of surface conditions leads to dubious models, suboptimal designs and cost penalties. This project therefore aims to advance our fundamental understanding of heat transfer accounting for the practical surface conditions of roughness, solid-fluid pairing and uneven heating. Building on capabilities that now place systematic data within reach, this project will deliver physics-based models that can robustly predict heat transfer, leading to reduced costs of energy and transport.Read moreRead less