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Role Of Integrin Signalling In Breast And Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$411,931.00
Summary
Integrins have an essential role in the control of mammary gland development and cell function. During tumour progression, integrins enable cancer cells to detach, proliferate, migrate and survive during metastasis. To test whether integrins regulate breast and prostate tumour progression, mice with mammary or prostate specific integrin deletion will be crossed with mice engineered to develop cancer. The effects of integrin loss on tumour growth and metastasis will be determined.