An Integrated Study Of Acyclic Nucleoside Phosphonates As Antimalarial Drugs
Funder
National Health and Medical Research Council
Funding Amount
$500,544.00
Summary
Malaria is one of the most serious infectious diseases today. Because of increasing resistance to existing medicines, new drugs are now needed. The therapeutic agents we will develop target the principal species responsible for human malaria are Plasmodium falciparum and vivax. Specifically, the compounds will prevent the parasite from replicating and are related in structure to those compounds in use to treat viral infections including AIDS.
Design And Delivery Of Peptide-based Anti-cancer Grb7 Inhibitors
Funder
National Health and Medical Research Council
Funding Amount
$603,126.00
Summary
The Grb7 protein is overproduced in many types of cancer cells and plays a role in cancer cell growth and spread. The current proposal builds upon the discovery of a peptide-based Grb7 inhibitor that has anti-cancer activity. This proposal is to prepare more potent inhibitor molecules that can efficiently reach the target cancer cells. Such molecules will be used for the study of Grb7 and for the development of a new Grb7-based anti-cancer drug therapy.
LMO2-containing Complexes In Leukemia And Blood Cell Development
Funder
National Health and Medical Research Council
Funding Amount
$803,652.00
Summary
Childhood T-cell leukemias have a poor prognosis for recovery. We are determining, with atomic level precision, how the proteins Lmo2 (also linked to prostate and other cancers) and Tal1, and their binding partners contribute to both normal blood cell development and T-cell leukemia. With this information we are developing reagents that can be used to disrupt disease-causing complexes, and which will lead towards the development of new, specific, therapeutics for leukemias and other cancers.
Molecular And Structural Basis Of Signalling By TIR Domain-containing Adaptors In TLR Pathways
Funder
National Health and Medical Research Council
Funding Amount
$666,417.00
Summary
Humans first detect the presence of pathogens and respond to them through specific pathways termed innate immune pathways. The proposed research will study proteins that participate in these pathways, in particular their three-dimensional structures and how they interact with each other, to understand how they work together to mount an immune response, and to find ways to modulate this response in infectious diseases as well as chronic inflammatory diseases.