Signalling pathways for sexual differentiation of apicomplexan parasites. This project aims to study the sexual development of apicomplexan parasites, which cause major diseases in humans, livestock and wildlife, including malaria. Only sexually differentiated cells can survive in the mosquito vector and hence this development is essential for the parasite's life-cycle. This project will employ a new approach that separates female from male parasites, thus enabling new information to be gleaned ....Signalling pathways for sexual differentiation of apicomplexan parasites. This project aims to study the sexual development of apicomplexan parasites, which cause major diseases in humans, livestock and wildlife, including malaria. Only sexually differentiated cells can survive in the mosquito vector and hence this development is essential for the parasite's life-cycle. This project will employ a new approach that separates female from male parasites, thus enabling new information to be gleaned about the development of these parasites. The expected outcomes are an understanding of the mechanisms of sexual differentiation and a functional characterisation of novel sex-specific molecules. This will provide significant benefits, such as pivotal prerequisites for new approaches to parasite intervention.Read moreRead less
The cellular basis of sex-specific responses to virus infection. This project aims to explore how the sex of cells impacts virus infections in culture. To date, the sex of cells in culture has been overlooked as an important source of biological variability, but may be found to affect basic science through to anti-viral drug discovery. Using a model in which a virus can be adapted to grow better in cells of a single sex, this project expects to generate new knowledge about how sex differences im ....The cellular basis of sex-specific responses to virus infection. This project aims to explore how the sex of cells impacts virus infections in culture. To date, the sex of cells in culture has been overlooked as an important source of biological variability, but may be found to affect basic science through to anti-viral drug discovery. Using a model in which a virus can be adapted to grow better in cells of a single sex, this project expects to generate new knowledge about how sex differences impact virus-host interactions. This project expects to provide new insights into sex-based differences in how cells detect and respond to virus infection, and the extent to which the sex of cells impacts viruses in general.Read moreRead less
Exploring The Occurrence And Potential Associated Risk Factors For Pilchard Orthomyxovirus (POMV) In Tasmanian Farmed Atlantic Salmon
Funder
Fisheries Research and Development Corporation
Funding Amount
$209,295.62
Summary
Following basic epidemiology principles, no infectious disease occurs ‘randomly’ and its occurrence follow logical and predictable patterns. The presence of an infectious agent is unlikely sufficient to explain these patterns and most aquatic diseases result from the complex interaction between the agent, the host and its environment. Therefore, the targeted outcome for a POMV control plan is threefold: 1. Decrease transmission between infected and susceptible fish groups – this requires ide ....Following basic epidemiology principles, no infectious disease occurs ‘randomly’ and its occurrence follow logical and predictable patterns. The presence of an infectious agent is unlikely sufficient to explain these patterns and most aquatic diseases result from the complex interaction between the agent, the host and its environment. Therefore, the targeted outcome for a POMV control plan is threefold: 1. Decrease transmission between infected and susceptible fish groups – this requires identifying risk factors associated with the introduction, spread, and maintenance of the pathogen within the industry; 2. Decrease the number of susceptible fish – this mainly requires identifying risk factors associated with the susceptibility of the host (e.g. husbandry-related stress) and the development of a safe and effective prophylaxis; 3. Decrease the amount of virus in the environment - this requires detecting infected fish cage(s) early to implement timely control strategies. Diagnostic capacity to confirmed POMV outbreak has been developed and is currently used in routine by the industry. A vaccine against POMV is currently under development at the Tasmanian Aquatic Animal Health and Vaccines Centre of Excellence and will be available in the future. However, little is known about risk factors specific to POMV and about its full economic impact. We define as a ‘risk factor’ any attribute of the agent, the host or its environment that increases the risk and intensity of a disease outbreak. Most of the environmental risk factors (including farming practices) facilitate the introduction, transmission, or maintenance of the pathogen; while the host risk factors affect the susceptibility of the host and its capacity to become diseased. Like the closely related ISAv, the magnitude and occurrence of POMV outbreaks appeared to be highly variable. This supports the existence of additional factors other than the POMV infection that contribute to the intensity of an outbreak. It is anticipated that by identifying and intervening on some of the manageable risk factors, the frequency and the severity of POMV outbreaks can be reduced. Objectives: 1. Describe the occurrence of POMV outbreaks in the Tasmanian salmon industry 2. Quantify the direct financial impact of POMV mortality to the Tasmanian salmon industry 3. Identify potential management, environmental and stock risk factors directly or indirectly increasing the risk and intensity of a POMV outbreaks Read moreRead less
How do apicomplexan parasites steal amino acids from their hosts? The single-celled parasites that cause malaria and toxoplasmosis are adept at stealing nutrients from the host animals that they infect. How they do this is, however, poorly understood. This project seeks to identify the processes by which these parasites scavenge amino acids, an essential class of nutrient, from their hosts. Using innovative experimental approaches, the project aims to identify and characterise the parasite prote ....How do apicomplexan parasites steal amino acids from their hosts? The single-celled parasites that cause malaria and toxoplasmosis are adept at stealing nutrients from the host animals that they infect. How they do this is, however, poorly understood. This project seeks to identify the processes by which these parasites scavenge amino acids, an essential class of nutrient, from their hosts. Using innovative experimental approaches, the project aims to identify and characterise the parasite proteins that mediate the uptake of different amino acids into the parasite. The intended outcomes of the project are to provide comprehensive insights into a fundamental aspect of parasite biology, and inform strategies to treat the diseases caused by these parasites by cutting off their nutrient supply.Read moreRead less
Minor Use Permit For Oxytetracycline In Marine And Freshwater Crustaceans
Funder
Fisheries Research and Development Corporation
Funding Amount
$75,000.00
Summary
This project will develop a Minor Use Permit application for oxytetracycline for use in crustacean aquaculture comprising: - a human health assessment focusing on worker exposure to OTC through mixing and administration - an environment assessment comprising use of existing trigger values with estimated release volumes of chemicals to understand environmental safety and to develop environmental release conditions - an efficacy and safety summary based on published information As ....This project will develop a Minor Use Permit application for oxytetracycline for use in crustacean aquaculture comprising: - a human health assessment focusing on worker exposure to OTC through mixing and administration - an environment assessment comprising use of existing trigger values with estimated release volumes of chemicals to understand environmental safety and to develop environmental release conditions - an efficacy and safety summary based on published information Assembly of these and all other relevant data into a Minor Use Permit application and submission to APVMA. Objectives: 1. Obtain a minor use permit for oxytetracycline use in crustacean aquaculture Read moreRead less
The Feasibility Of A Financial Safety-net: Investigating Financial Mechanisms To Protect Oyster Growers From Disease Outbreaks
Funder
Fisheries Research and Development Corporation
Funding Amount
$100,000.00
Summary
The oyster industry have long recognised their exposure to the unpredictable nature of the environment. Considerable time, effort and resources have been invested in risk mitigation activities. Examples such as Selective Breeding Programs, Quality Assurance Programs, Environmental Management Systems and innovations in growing techniques and animal husbandry are all designed to improve the attritubes of stock and to mitigate the likelihood & severity of a disturbance. It has been identified howev ....The oyster industry have long recognised their exposure to the unpredictable nature of the environment. Considerable time, effort and resources have been invested in risk mitigation activities. Examples such as Selective Breeding Programs, Quality Assurance Programs, Environmental Management Systems and innovations in growing techniques and animal husbandry are all designed to improve the attritubes of stock and to mitigate the likelihood & severity of a disturbance. It has been identified however, that there has been minimal investment in last resort options that support growers through worst-case scenarios.
While state & federal disaster arrangements are well established to support primary producers following declared natural disasters, the same mechanisms do not exist for disease outbreaks. Attempts to establish an aquatic deed (officially known as the aquatic EADRA - Emergency Aquatic Disease Response Arangement) have so far failed, and traditional stock insurance (such as that available to cattle producers, or ranched tuna) is not readily available to oyster farmers.
This situation has escalted following the Qx outbreak in Port Stephens, NSW. Despite suffering catastophic losses, oyster farmers in this estuary have received little support, beyond fee waivers and assistance associated with flooding events in the region. In 2019, the estuary hosted ~45 oyster farming businesses with an annual GVP of well-over $10m. Almost all of these businesses are now operating part-time, and even the most productive and profitable of growers have needed to find off-farm work to supplement their income. With considerable infrastructure in the water, farmers are unable to walk away from leases, as tipping fees alone are estimated to exceed $5m.
Understandably growers around the state have been rocked by the outbreak, the associated response and lack of financial support, and as a result have been reassessing their own exposure to risk. One thing that has also become clear, is that industry needs to take charge of their own future and look at measures to support their recovery, reestablishment or dignified exit following disease incursions.
This application seeks funding support for NSW Farmers to drive this process. This will involve the development and administration of a tender and contracting process to deliver an options document exploring the advantages and drawbacks of various financial support mechanisms current available and their appropraiteness for implementation in the oyster industry. This will include the investigation of solutions that are estbalished in other states, and other agricultural sectors. It is anticipated that recommedations put forward will be broadly split into 1) mechanisms that can be implemented at the farm/enterprise level, 2) mechanisms that may be implemented at the state/sector-wide level.
The options paper will provide valuable information which may inform the actions of fishing & aquaculture sectors around the country. Objectives: 1. By October 2024, obtain insights into potential financial support mechanisms, and their suitability for implementation in the NSW oyster industry. Read moreRead less