The Centre will enhance Australian clinical immunisation research and training, focussing upon clinical questions with translatable outcomes not easily addressed by industry. Optimal immunisation and interventions to maximise uptake of existing and new vaccines in high risk patient groups, such as children with cancer, immigrants, children with chronic diseases and adolescents will be studied. New vaccine trials, innovative use of existing vaccines, systematic collection of vaccine failure data, ....The Centre will enhance Australian clinical immunisation research and training, focussing upon clinical questions with translatable outcomes not easily addressed by industry. Optimal immunisation and interventions to maximise uptake of existing and new vaccines in high risk patient groups, such as children with cancer, immigrants, children with chronic diseases and adolescents will be studied. New vaccine trials, innovative use of existing vaccines, systematic collection of vaccine failure data, and targeted epidemiology and disease modelling vaccine preventable disease will also allow a broad program of research, enabling training and mentoring of young clinical nurse and physician researchers. Collaborations with existing national immunisation, infectious diseases and research institutions will allow maximal effectiveness of clinical studies.Read moreRead less
Reducing Vaccine Preventable Diseases In Children: Using National Active Hospital-based Surveillance To Evaluate And Improve Immunisation Program Performance
Funder
National Health and Medical Research Council
Funding Amount
$1,049,916.00
Summary
This proposal aims to evaluate and improve upon immunisation policy and programs for the prevention of severe childhood influenza and pertussis. Using our successful Paediatric Active Enhanced Disease Surveillance (PAEDS) network in 6 major children's hospitals across Australia, we will identify gaps in the evidence base needed to better control influenza and pertussis and in particular to ensure programs are delivered in such a way so as to address health inequalities.
Immunisation Practice And Policy Development In Australia: Urgent Priorities In Prevention Of Infectious Diseases In Children, Adolescents And Pregnant Women
Funder
National Health and Medical Research Council
Funding Amount
$473,477.00
Summary
Our research aims to optimise protection for infants and children against serious infectious diseases causing death and disability, such as whooping cough, influenza and meningococcal disease. We will establish the safety and effectiveness of vaccines to improve protection against these infections. Our community research will determine the best ways to improve uptake of immunisation in children and in pregnant women to provide the best protection for infants and mothers.
Comparing Pneumococcal Vaccines In A High Risk Population: A Randomised Controlled Trial Of Immunogenicity, Safety And Impact On Carriage Of Pneumococcal Conjugate And Polysaccharide Vaccines In Infants In Papua New Guinea
Funder
National Health and Medical Research Council
Funding Amount
$1,042,670.00
Summary
Pneumococcal disease is a major cause of pneumonia and meningitis in infants in developing countries in particular resulting in an estimated 800,000 deaths each year. This project will study how well pneumococcal vaccines perform in 260 high-risk infants in Papua New Guinea. We will examine how well the vaccines stimulate protective immunity and reduce babies carrying the pneumococcal bacteria in their nose and how long this immunity lasts for. The study will inform global immunisation policy.
Immunisation Practice And Policy Development In Australia: Responding To Urgent Priorities In Prevention Of Endemic And Epidemic Infectious Diseases In Children.
Funder
National Health and Medical Research Council
Funding Amount
$401,361.00
Summary
Despite high immunisation coverage rates in Australia deaths still occur in young infants from vaccine preventable diseases such as whooping cough, meningitis and influenza. My research in vaccines and immunisation involves trialing new vaccines such as meningococcal B and H1N1 vaccine to ensure their safety and effectiveness in children and investigation of new ways to deliver vaccines to improve uptake of new vaccines in the community to ensure earlier and better protection for infants and chi ....Despite high immunisation coverage rates in Australia deaths still occur in young infants from vaccine preventable diseases such as whooping cough, meningitis and influenza. My research in vaccines and immunisation involves trialing new vaccines such as meningococcal B and H1N1 vaccine to ensure their safety and effectiveness in children and investigation of new ways to deliver vaccines to improve uptake of new vaccines in the community to ensure earlier and better protection for infants and children against severe infectious diseases.Read moreRead less