Randomised Controlled Evaluation Of A Complex Intervention To Promote Uptake Of School-based HPV Vaccination
Funder
National Health and Medical Research Council
Funding Amount
$750,911.00
Summary
Adolescents have little understanding and high levels of fear about HPV vaccination in the Australian school program. We plan to evaluate a multi-strategy intervention (incorporating an adolescent education intervention, a parental decision aid, and procedural facilitators) to promote uptake and informed participation in the school-based HPV vaccination program. The intervention will promote understanding, reduce fear, and have minimum impact on school and teacher resources.
Comparing Pneumococcal Vaccines In A High Risk Population: A Randomised Controlled Trial Of Immunogenicity, Safety And Impact On Carriage Of Pneumococcal Conjugate And Polysaccharide Vaccines In Infants In Papua New Guinea
Funder
National Health and Medical Research Council
Funding Amount
$1,042,670.00
Summary
Pneumococcal disease is a major cause of pneumonia and meningitis in infants in developing countries in particular resulting in an estimated 800,000 deaths each year. This project will study how well pneumococcal vaccines perform in 260 high-risk infants in Papua New Guinea. We will examine how well the vaccines stimulate protective immunity and reduce babies carrying the pneumococcal bacteria in their nose and how long this immunity lasts for. The study will inform global immunisation policy.
FluMum: A Prospective Cohort Study Of Mother-infant Pairs Assessing The Effectiveness Of Maternal Influenza Vaccination In Prevention Of Influenza In Early Infancy
Funder
National Health and Medical Research Council
Funding Amount
$2,598,377.00
Summary
Influenza is a serious illness for young babies. Currently there are no vaccines that can be given to babies under 6 months of age to protect them from infection. This study aims to determine whether influenza vaccine given in pregnancy can prevent infection in babies up to 6 months of age.
Preventing Early-onset Pneumonia In Indigenous Infants Through Maternal Immunisation: A Multi-centre Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$3,210,618.00
Summary
We plan a study where Indigenous pregnant women will be immunised with a licensed vaccine to determine if it prevents acute lung infections in their children. A randomised design will be used based on our previous work. We will also undertake 2 novel sub-studies on infant immune function and reasons why women refuse immunisation. If successful, this study will alter immunisation policy and prevent lung infections and future chronic lung diseases that are common in Indigenous children and adults.
BCG Immunisation To Prevent Allergy In Children: An Intervention Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,187,260.00
Summary
There has been a dramatic rise in allergic diseases (asthma, eczema, food allergy) worldwide and particularly in Australia, with up to 30% of children affected. There is evidence from small studies that BCG immunisation has beneficial effects that prevent an allergic type immune response later in life. In a large randomised trial we will determine whether BCG at birth prevents allergic disease by monitoring eczema and food sensitivity in infancy, both of which predict an allergic predisposition.
Developing Evidence Based Strategies For Addressing Childhood Vaccination Rejection
Funder
National Health and Medical Research Council
Funding Amount
$743,927.00
Summary
Parental rejection of vaccines is a global concern that threatens to undermine disease control. A lack of evidence hampers the responses to this complex and persistent problem. We will interview parents who don’t vaccinate their children to learn what influences their decisions. We will then hold community juries and a public engagement process to refine strategies for responding to vaccination rejection that are acceptable to a well informed citizenry, practical and ethically justified.
Enhancing Vaccine Efficacy By Harnessing Dendritic Cell Receptors And Their Unique Properties
Funder
National Health and Medical Research Council
Funding Amount
$687,519.00
Summary
Potent vaccination might be achieved by using monoclonal antibodies as magic bullets to target vaccines to special cells in the body. We show that targeting these special cells by using monoclonal antibodies that recognise Clec9A is effective, perhaps because it brings several different immune cells together so that they orchestrate very efficient immune responses. This application investigates how targeting Clec9A allows strong vaccination so that we can apply this to new generation vaccines.
Dynamics Of Haemophilus Haemolyticus And Nontypeable Haemophilus Influenzae Colonisation In Otitis-prone Children
Funder
National Health and Medical Research Council
Funding Amount
$358,790.00
Summary
A vaccine has been licenced that reduces ear disease. A harmless bacterium masquerades as the pathogen responsible for ear disease, nontypeable Haemophilus influenzae (NTHi), leading to inaccurate surveillance of ear disease. This project will measure the true proportion of NTHi in ears and noses to help policy decisions regarding the introduction of the vaccine to Western Australia. We will be able to assess the impact this vaccine has had in the Northern Territory since implementation in 2009.
Does Pneumococcal Vaccination Protect Against Cardiovascular Disease? A Randomised Placebo-controlled Double Blind Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,849,245.00
Summary
Australian researchers have set up a novel multi-centre trial to investigate the effects of the pneumococcal vaccination in reducing heart attacks and stroke. People aged 55 to 61 from 6 sites around Australia will be invited to participate in the study. The selected participants will attend a clinic in their area and will be randomly given the pneumococcal vaccine or a placebo vaccine. Outcomes on the expected 6000 participants will be ascertained by health record linkage with government databa ....Australian researchers have set up a novel multi-centre trial to investigate the effects of the pneumococcal vaccination in reducing heart attacks and stroke. People aged 55 to 61 from 6 sites around Australia will be invited to participate in the study. The selected participants will attend a clinic in their area and will be randomly given the pneumococcal vaccine or a placebo vaccine. Outcomes on the expected 6000 participants will be ascertained by health record linkage with government databases after 4 years.Read moreRead less
Falls Prevention In The Acute Hospital Setting: A Multi-centre Cluster Randomised Controlled Trial Of Efficacy, Cost Effectiveness And Sustainability Of The 6-PACK Program.
Funder
National Health and Medical Research Council
Funding Amount
$1,218,771.00
Summary
Older people commonly fall in hospital suffering injuries such as a broken hip which are costly for the faller and hospital. Falls can result in a nursing home stay as they reduce a person's confidence and ability to do simple tasks like showering. We have designed a program with the potential to reduce fall injuries, using an approach with promising results from one hospital. This project will evaluate this program that aims to improve the care of older people in hospital.