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Maternal And Neonatal Vaccination - How Early Can We Protect Infants?
Funder
National Health and Medical Research Council
Funding Amount
$196,331.00
Summary
Currently, only hepatitis B vaccine is routinely given at birth and for all other vaccines the earliest recommended administration is at 6 weeks old. This is too late to protect infants against pertussis and the most severe cases (hospitalisation or death) occur before 4 months. This research aims to assess if birth pertussis vaccination can protect infants earlier, measure the longevity of immunity following birth hepatitis B vaccination and examine the potential role for maternal vaccination
Prevalence Of Genital HPV Infection In Males Following Introduction Of Universal Male HPV Vaccination
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
As Australia is the first and only country to implement a free universal school based male human papillomavirus (HPV) vaccination program (in 2013), this project has the unique opportunity to be first to study to assess the effectiveness of the male HPV vaccination program in Australia by measuring a change in the prevalence of HPV among young (aged 17-20) heterosexual and homosexual men following the implementation of the vaccination program.
Studying The Function And Mechanism Of Histone ADP-ribosylation; (ii) Lipo-peptide--protein Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$496,076.00
Summary
(i) Histones, which act as DNA supports, are subject to modifications, which may be associated with disease (e.g. cancers). A better understanding of these modifications will provide access to new medicines (ii) The production of new vaccines requires new vaccine development tools. We propose to use fats to produce vaccines which can be delivered via the mouth or nose rather than by injection.
Applying Active Hospital-based Case Ascertainment To Assess Vaccine Effectiveness And Safety
Funder
National Health and Medical Research Council
Funding Amount
$258,741.00
Summary
Australia makes a considerable investment in vaccination, and the public are entitled to expect that vaccines are both safe and effective. The growing complexity of the vaccine schedule requires the development of new and flexible systems to monitor vaccine performance. This project aims to do this using surveillance nurses embedded in children's hospitals to actively find cases of diseases which are potentially vaccine-preventable as well as those which might have occurred as a side effect of v ....Australia makes a considerable investment in vaccination, and the public are entitled to expect that vaccines are both safe and effective. The growing complexity of the vaccine schedule requires the development of new and flexible systems to monitor vaccine performance. This project aims to do this using surveillance nurses embedded in children's hospitals to actively find cases of diseases which are potentially vaccine-preventable as well as those which might have occurred as a side effect of vaccination.Read moreRead less
Towards Improved Maternal And Childhood Vaccine Uptake: Managing The Challenge And Opportunity Of Complementary Medicine Practitioners
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Certain geographical areas with lower rates of vaccination pose considerable concern. Complementary medicine practitioners are often visited by vaccine-hesitant parents and are influential in their decisions about vaccination. This research provides the first examination of complementary medicine practitioner beliefs and practices regarding vaccination. Resources will be developed to help manage conversations between complementary medicine practitioners and vaccine-hesitant parents.
Population-based Data Linkage And Modelling Studies To Evaluate And Inform Australia’s Immunisation Program
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Despite the overall success of immunisation programs, outbreaks of preventable diseases continue and Indigenous children still suffer a higher burden of illness. We will study a cohort of infants in New South Wales and data about their illnesses and vaccinations to provide accurate measures program performance. The findings will aid development of strategies to target high risk children, and more realistic models about future outcomes, so that the benefits of immunisation are optimised.
Prevention Of Pertussis From Birth Through Maternal Immunisation
Funder
National Health and Medical Research Council
Funding Amount
$197,657.00
Summary
Whooping cough or pertussis is a significant cause of death in infants worldwide. Newborns remain at risk until they have received 1 to 2 doses of pertussis vaccine (around 4 months of age). My project involves investigating whether giving pertussis vaccine in the third trimester of pregnancy provides passive protection (via transplacental transfer of antibody) to the infant in sufficient levels for protection against whooping cough in early infancy.