Immune Balance-regulating Interleukins As Targets For Immunotherapy
Funder
National Health and Medical Research Council
Funding Amount
$473,477.00
Summary
The immune balance is crucial to human health. Interleukins are a group of proteins secreted by immune cells to mediate their communication. They tune up or down immune responses, thus as attractive targets for immunotherapy to restore the immune balance to treat autoimmune diseases, allergies and infections. This fellowship will support translational research to develop Interleukin-2 (IL-2) and IL-21-based novel immunotherapies for autoimmune disease, infection and allergy.
The Role Of Interleukin (IL)-27 In The Germinal Centre Reaction During Normal And Autoimmune Responses
Funder
National Health and Medical Research Council
Funding Amount
$476,226.00
Summary
Protective immune responses depend on supportive interactions between different white blood cell types. Signalling proteins called _cytokines� are a key means of communication between cells. Abnormal cytokine production can lead to poor protection against infection or immune attack against the tissues (ie. autoimmune disease). This project aims to determine the importance of one such cytokine, called IL-27, in the production of antibodies in normal immune responses as well as in autoimmune disea ....Protective immune responses depend on supportive interactions between different white blood cell types. Signalling proteins called _cytokines� are a key means of communication between cells. Abnormal cytokine production can lead to poor protection against infection or immune attack against the tissues (ie. autoimmune disease). This project aims to determine the importance of one such cytokine, called IL-27, in the production of antibodies in normal immune responses as well as in autoimmune diseases like Lupus.Read moreRead less