Circular Plant Proteins with Pharmaceutical Applications. The proposed research will develop methods for using plants as protein production factories. Initially I will use plants to create engineered cyclotides that incorporate peptides with proven therapeutic activity against cancer and multiple sclerosis. Successful production of therapeutic proteins in plants will benefit Australians by making treatments for these and other diseases more accessible. It also has the potential for a major econo ....Circular Plant Proteins with Pharmaceutical Applications. The proposed research will develop methods for using plants as protein production factories. Initially I will use plants to create engineered cyclotides that incorporate peptides with proven therapeutic activity against cancer and multiple sclerosis. Successful production of therapeutic proteins in plants will benefit Australians by making treatments for these and other diseases more accessible. It also has the potential for a major economic benefit from the sales of Australian-based drugs. This proposal will also provide outstanding research training for graduate students in multidisciplinary methods that constitute state-of the-art structural and plant molecular biology.Read moreRead less
Vortex fluidic mediated chemical transformations. This project aims to develop a continuous flow vortex fluidic device (VFD) for chemical and biochemical transformations. Vortex fluidic devices should lead to cleaner and faster ways of preparing complex molecules. Depending on the VFD’s operating parameters, including applying field effects such as Faraday waves, plasmas and light sources, reactions could have higher yields and selectivity than traditional batch processing. This will be translat ....Vortex fluidic mediated chemical transformations. This project aims to develop a continuous flow vortex fluidic device (VFD) for chemical and biochemical transformations. Vortex fluidic devices should lead to cleaner and faster ways of preparing complex molecules. Depending on the VFD’s operating parameters, including applying field effects such as Faraday waves, plasmas and light sources, reactions could have higher yields and selectivity than traditional batch processing. This will be translated into molecular assembly line syntheses in a single unit or a series. Such syntheses should provide a versatile toolbox for molecular transformations, under continuous flow conditions where scalability is addressed upfront. This will be attractive to industry and minimise effects on the environment.Read moreRead less
Modular Vortex Fluidic Mediated Molecular Transformations. The project aims to develop the use of electric and magnetic fields to control chemical and biochemical reactions in high shear thin films under readily scalable continuous flow conditions to then be able to precisely build complex functional molecules. Depending on the orientation, strength and frequency of external electric and magnetic fields, and novel shear stress induced electric fields in solution, rates of reactions can be enhanc ....Modular Vortex Fluidic Mediated Molecular Transformations. The project aims to develop the use of electric and magnetic fields to control chemical and biochemical reactions in high shear thin films under readily scalable continuous flow conditions to then be able to precisely build complex functional molecules. Depending on the orientation, strength and frequency of external electric and magnetic fields, and novel shear stress induced electric fields in solution, rates of reactions can be enhanced, with higher yields and tunable selectivity, and reduced waste and energy usage, which is not possible using traditional batch processing. This will be translated into molecular assembly line processing and the development of a new synthetic toolbox, with applications in preparing pharmaceuticals.
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