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Mechanisms Underlying The Effects Of Retinoic Acid Receptor Gamma In Haemopoiesis And Bone Homeostasis
Funder
National Health and Medical Research Council
Funding Amount
$366,801.00
Summary
My recent studies have demonstrated that a model of vitamin A deficiency results in impaired blood cell production and contributes to a blood cell disorder that can progress to leukaemia. There are also reduced numbers of blood stem cells (which give rise to all blood cells) and bone (which helps to regulate blood cell production) in this mouse model. In these studies I seek to understand more on how vitamin A deficiency causes these defects, which may lead to better treatment of such diseases.
Investigating The Mechanism And Consequences Of Cytotoxic Lymphocyte Detachment
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Killer cells are white blood cells that destroy cancerous cells. To move to their next target they must quickly detach from a dying target. Failure of detachment results in excessive inflammation and tumour escape. This project will discover the detachment signals required to ‘release’ a locked-on killer cell. This will lead to a deeper understanding of immune pathology and new ways of treating cancer.
Improving Patient Outcomes In Leukaemia By Targeting Cancer Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$294,763.00
Summary
Blood cancers such as acute myeloid leukaemia (AML) are among the most deadly types of cancer and new treatments are desperately needed to improve patient’s survival in these diseases. AML cancer-causing stem cells survive by turning on immortalization programs and we hope to specifically kill these AML stem cells by blocking these crucial pathways. This includes things that control the way the cells divide and the way they respond to genetic damage as well as other novel pathways.
Using Human 3D Engineered Heart Tissue For Discovery Of Novel Biology And Novel Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
The goal of this project is to develop a model of miniaturised 3D human heart tissue for research into cardiac biology and also drug discovery applications. This will hopefully result in better, cheaper drugs in the future with less reliance on animal testing.
Using Connective Tissue Stem Cells To Treat Human Disease.
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
In our recent Cell paper (January 15, 2015), we reported our discovery of two new adult stem cells. One of these, the osteochondroreticular (OCR) bone stem cell (pronounced “ocker” stem cell) has a particular affinity for developing cartilage. We are testing if this cell could be used as a new treatment for osteoarthritis. The second new stem cell we discovered, is called the iRSC, and lies within the intestine. We are studying this cell in the development and treatment of bowel cancer.
The Role Of CD1-restricted T Cells In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
The human immune system requires T cells for survival. Specialised populations of T cells exist that patrol the body and target unwanted lipid molecules expressed by bacteria or by cells that have become abnormal or cancerous. I will identify these T cells in human blood and skin and determine their role in protection against disease. I will explore the types of lipids molecules recognised by these T cells and use this information to help prevent human diseases.