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Understanding The Establishment Of HIV Reservoirs And Development Of HIV Eradication Strategies
Funder
National Health and Medical Research Council
Funding Amount
$380,891.00
Summary
Understanding why, when, how and at what pace the HIV virus hides and establishes itself in one's body will allow us to design new ways for preventing and eliminating this reservoir of hidden HIV. As a clinician scientist in HIV and infectious diseases, I will drive clinical studies to explore the kinetics of HIV in patients who recently acquired HIV, those who start HIV treatment early, and those chronically infected with HIV so as to investigate novel means to minimise HIV hiding spots.
Immune Modulatory Interventions In People With HIV And Cancer: Prevention, Treatment, And Implications For HIV Eradication.
Funder
National Health and Medical Research Council
Funding Amount
$344,644.00
Summary
People with HIV are at increased risk of many cancers. New therapies that target the immune system may be useful in treating these cancers, and may also target the cells where HIV persists thereby assisting in eradication of HIV. This research program includes three clinical studies in people with HIV and cancer: one to learn more about their immunity; one to prevent, and one to treat certain cancers by modulating the immune system. Each also explores any effect on HIV eradication.
Human Papillomavirus Infection In Gay Australian Men: Natural History Of The Serological Response And The Relationship Between Seropositivity, Risk Factors And Anal Disease
Funder
National Health and Medical Research Council
Funding Amount
$185,822.00
Summary
Anal cancer rates are increasing globally. Gay men are 20 times more likely than other men to develop anal cancer and for those people living with HIV, the risk is even higher. Human papillomaviruses (HPV) have been shown to cause anal cancer. This research explores the natural history of anal HPV infection and the relationship between HPV infection and anal cancer. These results will potentially inform the development of guidelines for an anal cancer screening program for gay Australian men.
Prevalence Of Genital HPV Infection In Males Following Introduction Of Universal Male HPV Vaccination
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
As Australia is the first and only country to implement a free universal school based male human papillomavirus (HPV) vaccination program (in 2013), this project has the unique opportunity to be first to study to assess the effectiveness of the male HPV vaccination program in Australia by measuring a change in the prevalence of HPV among young (aged 17-20) heterosexual and homosexual men following the implementation of the vaccination program.
Human Genetic Susceptibility To Bacterial Invasion And The Interaction With Chronic Helminth Infections
Funder
National Health and Medical Research Council
Funding Amount
$377,040.00
Summary
A genetic study will be undertaken to identify genes that increase an individual’s risk of developing a bloodstream bacterial invasion following severe pneumonia, a leading cause of infant death world-wide. The risk of getting a bacterial infection is increased in individuals already infected with parasitic intestinal worms. This may also reduce drug and vaccine efficacy. Research will be undertaken to investigate these relationships for future drug and vaccination development.
Reducing Disparities In Cervical Cancer Incidence For Aboriginal And Torres Strait Islander Women Through Screening And Vaccination
Funder
National Health and Medical Research Council
Funding Amount
$329,768.00
Summary
This program of research will aim to reduce cervical cancer incidence for Indigenous women by developing and trialling health systems interventions to increase cervical screening participation and HPV vaccination coverage. This research will be led by an Indigenous researcher with Indigenous people and for Indigenous people.