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The Australian Study Of Child Health In Same-Sex Families
Funder
National Health and Medical Research Council
Funding Amount
$107,227.00
Summary
As a trainee public health physician concerned with the complete physical, mental and social wellbeing of children I will be investigating health outcomes for Australian children who live in families with same-sex attracted parents. This research will paint a picture of the current health status of these children and help to determine factors involved in determining their health outcomes. In particular the role of stigma and discrimination will be examined.
Anal Cancer Examination (ACE) Study - Annual Anal Examinations To Detect Early Anal Cancer In HIV Positive Men Who Have Sex With Men
Funder
National Health and Medical Research Council
Funding Amount
$60,926.00
Summary
Anal cancer is the most frequently occurring (non-AIDS defining) cancer in HIV positive men who have sex with men. There are still no guidelines for how to screen for this cancer. This research aims to determine the feasibility of implementing an annual anal examination to detect early anal cancer in HIV positive men who have sex with men.
Antiretroviral drugs reduce morbidity and mortality for people living with HIV however there is currently no cure for HIV. I will undertake a series of studies that will contribute to HIV cure research in Australia. This includes describing novel strategies to identify and measure residual dormant HIV in individuals on suppressive antiretroviral therapy, determining the effect of cancer drugs on dormant HIV, and exploring the attitudes of people living with HIV towards cure research.
Protocol Development For Study Design And Analysis In HIV Latency Research
Funder
National Health and Medical Research Council
Funding Amount
$73,836.00
Summary
This study will aim to improve the development and analysis of HIV research studies. Currently HIV studies looking at the virus that remains in the body even when taking medication for HIV are too small to produce consistent results. This research will look at the statistical methods used to analyse these studies and find the best method for analysis, as well as developing guidelines for choosing appropriate numbers of study participants in future studies to allow results to be more accurate.
The Role Of Chemokine Signalling In Maintenance Of The Latent HIV Reservoir
Funder
National Health and Medical Research Council
Funding Amount
$92,161.00
Summary
HIV cure research aims to eliminate cells with HIV in their DNA. These cells have higher levels of a receptor, CCR6, signalling through which causes migration to and concentration in the gut. This gut migration may help to maintain the HIV reservoir by bringing susceptible cells close to infected cells. We will assess the effect of blocking CCR6 signalling on the ability to infect these cells with HIV in the laboratory and its effect on the reservoir of an analogous virus in macaques.
The Impact Of The Identification And Inclusion Of Acceptable HLA-mismatches On The Transplant Potential Of Highly-sensitised Renal Transplant Candidates.
Funder
National Health and Medical Research Council
Funding Amount
$100,323.00
Summary
In Australia, allocation of donor kidneys are currently weighted largely on the degree of donor-recipient HLA compatibility. However, not all HLA mismatches leads to negative outcomes. Acceptable HLA-mismatches are antigen mismatches that can be considered compatible at a structural and functional level and have been applied to circumvent the problem of difficulty finding suitable donors for highly-sensitised transplant candidates. We apply this concept to the Australian kidney transplant popula ....In Australia, allocation of donor kidneys are currently weighted largely on the degree of donor-recipient HLA compatibility. However, not all HLA mismatches leads to negative outcomes. Acceptable HLA-mismatches are antigen mismatches that can be considered compatible at a structural and functional level and have been applied to circumvent the problem of difficulty finding suitable donors for highly-sensitised transplant candidates. We apply this concept to the Australian kidney transplant population.Read moreRead less
The Primary HIV Combined United Database (PCUD) is the largest database of patients with primary HIV infection in Australia. Dating back to 1983, it collects data from people with HIV seroconversion. Primary HIV infection, or seroconversion provides a unique opportunity to study HIV throughout its natural history. This study aims to link data on long term health outcomes such as AIDS, cancer and cardiovascular disease in this cohort, which can then be used to understand the determinants of progr ....The Primary HIV Combined United Database (PCUD) is the largest database of patients with primary HIV infection in Australia. Dating back to 1983, it collects data from people with HIV seroconversion. Primary HIV infection, or seroconversion provides a unique opportunity to study HIV throughout its natural history. This study aims to link data on long term health outcomes such as AIDS, cancer and cardiovascular disease in this cohort, which can then be used to understand the determinants of progression and complications of HIV infection.Read moreRead less
The Role Of Stellate Cells In Fibrosis And Liver Disease Progression In HIV-Hepatitis B Co-infection
Funder
National Health and Medical Research Council
Funding Amount
$157,292.00
Summary
Liver related mortality is the commonest cause of non-AIDS death in HIV infected individuals on treatment. With HIV, HBV liver damage is accelerated and liver-related mortality increased. Understanding how and why is critical to management. I will examine the role of hepatic stellate cells using in vitro models and directly ex vivo from infected patient biopsy tissue. I will investigate the activated of these cells by HIV and HBV infection, thus promoting scar formation with liver injury.
Evaluating The Burden And Aetiology Of Medical Comorbidities Among People With HIV In Australia: Towards The Optimal Management Of The Ageing HIV Positive Population
Funder
National Health and Medical Research Council
Funding Amount
$105,599.00
Summary
People with HIV are living longer due to better HIV medications. People with HIV also have more medical problems (like heart disease and cancer) than HIV negative persons. Therefore, treating these other medical conditions is becoming a larger part of caring for people with HIV. This research focuses on: 1) Understanding how common these medical conditions are among people with HIV; and 2) Identifying the reasons behind why people with HIV have more medical problems than HIV negative people.
Antigen-specific Regulatory T Cells And HLA Associations In Autoimmune Renal Disease
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Glomerulonephritis (GN), a common cause of kidney failure, usually results from an immune system attack on the kidneys. Current treatments suppress the whole immune system, making patients vulnerable to infection. We aim to harness the body’s protective immune cells (Tregs) as a potential GN treatment. Using mice genetically programmed to mimic a human GN, we will test if specifically targeted Tregs protect mice from disease. We will also test how they affect blood samples from humans with GN.