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Ink jet microfluidic spray drier for making high quality microencapsulated bioactive particles and nanosized particles. The proposal addresses National Research Priority area 3 (Frontier Technology). This work will develop a new, simple and effective method for producing designer smart particles that have better functional properties as well as improved uniformity for application in the food and pharmaceutical industries. The project will train graduates who will be able to make a high-level con ....Ink jet microfluidic spray drier for making high quality microencapsulated bioactive particles and nanosized particles. The proposal addresses National Research Priority area 3 (Frontier Technology). This work will develop a new, simple and effective method for producing designer smart particles that have better functional properties as well as improved uniformity for application in the food and pharmaceutical industries. The project will train graduates who will be able to make a high-level contribution to these Australian industries. This will also mark a development in Australia¡¯s nanotechnology capability in the bio-area.Read moreRead less
Molecular Interactions of Chemical Agents with Ion-Channel Proteins. With a minimal number of functional units (proteins) viruses are able to replicate. All of these proteins are possible antiviral targets. In this project we wil1 focus on a short protein called Vpu found in membranes of the HIV-1 virus and aim to analyse the interaction of potential pore blocking compounds. It is essential to know exactly where they sit and how the overall structure of Vpu is affected. For this enterprise we wi ....Molecular Interactions of Chemical Agents with Ion-Channel Proteins. With a minimal number of functional units (proteins) viruses are able to replicate. All of these proteins are possible antiviral targets. In this project we wil1 focus on a short protein called Vpu found in membranes of the HIV-1 virus and aim to analyse the interaction of potential pore blocking compounds. It is essential to know exactly where they sit and how the overall structure of Vpu is affected. For this enterprise we will use nuclear magnetic resonance (NMR) spectroscopy. This information will serve as a springboard for future investigations of virus membrane proteins.
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Metal-Based Anti-inflammatory Drugs with High Efficacy and Low Side-Effects. Non-steroidal anti-inflammatory drugs (NSAIDs) have widespread human and veterinary applications for the treatment of arthritis and other inflammatory diseases, but their utility is limited by often severe gastrointestinal, renal and cardiac side-effects. The recently heralded COX-2 inhibitors have not lived up to their expectations in terms of efficacy and side-effects, therefore, there is a need to develop new potent ....Metal-Based Anti-inflammatory Drugs with High Efficacy and Low Side-Effects. Non-steroidal anti-inflammatory drugs (NSAIDs) have widespread human and veterinary applications for the treatment of arthritis and other inflammatory diseases, but their utility is limited by often severe gastrointestinal, renal and cardiac side-effects. The recently heralded COX-2 inhibitors have not lived up to their expectations in terms of efficacy and side-effects, therefore, there is a need to develop new potent, but safer, NSAIDs. This project is aimed at using the results from new lead compounds to design NSAIDs with much greater efficacy and much less side effects than those currently available.Read moreRead less
Powder blending for dry powder inhalers: a new approach for direct control of powder structure. Over 80 per cent of pharmaceutical products involve the processing of powders. This project will generate new knowledge of how to assemble fine and cohesive particles into the structure required for dry powder inhaler products, leading to the development of new low-cost medicines in Australia and the Asia Pacific region.
Targeting particulate carriers to epithelial M cells. This project aims to develop and validate an advanced in vitro model of the human intestinal epithelium. The intestine-on-chip model should enable mechanistic studies of the uptake of nano- and micron-size particles by intestinal cells and deliver new insights into the way particulate carriers can be specifically targeted and transported across the intestinal epithelium. Project knowledge and technology are anticipated to generate new commerc ....Targeting particulate carriers to epithelial M cells. This project aims to develop and validate an advanced in vitro model of the human intestinal epithelium. The intestine-on-chip model should enable mechanistic studies of the uptake of nano- and micron-size particles by intestinal cells and deliver new insights into the way particulate carriers can be specifically targeted and transported across the intestinal epithelium. Project knowledge and technology are anticipated to generate new commercialisation opportunities in the oral delivery industry and ultimately, should drive the development of efficient oral formulations for biologics. The model should also reduce the need for animal studies.Read moreRead less
Targeted process development for drug delivery. Matrix assisted ball milling and continuous flow process intensification on rotating surfaces in the form of spinning discs and rotating tubes, and combinations of these, allow the fabrication of nanoparticles for the pharmaceutical industry, with the ability to fine tune the properties of the particles to improve their uptake profiles, while minimising side effects. The research will be conducted through the Centre for Strategic Nano-Fabrication w ....Targeted process development for drug delivery. Matrix assisted ball milling and continuous flow process intensification on rotating surfaces in the form of spinning discs and rotating tubes, and combinations of these, allow the fabrication of nanoparticles for the pharmaceutical industry, with the ability to fine tune the properties of the particles to improve their uptake profiles, while minimising side effects. The research will be conducted through the Centre for Strategic Nano-Fabrication with its science based attention to quality by design for product development at the inception of the science. This, coupled with the involvement of iCeutica which has a strong commercially focused R and D profile, provides a more innovative research culture, and excellent research training. Read moreRead less
The Development of New Carrier Technologies for Spray-Dried Fruit Extracts. This project aims to develop new carrier techniques for spray drying fruit extracts based on the use of natural fibres, with the aim of overcoming a key problem in the operation of spray dryers for producing powders, the deposition of particles on walls. Carriers are non-sticky materials that effectively dilute the stickiness of any materials. The significance is that it will use waste products from fruit processing (th ....The Development of New Carrier Technologies for Spray-Dried Fruit Extracts. This project aims to develop new carrier techniques for spray drying fruit extracts based on the use of natural fibres, with the aim of overcoming a key problem in the operation of spray dryers for producing powders, the deposition of particles on walls. Carriers are non-sticky materials that effectively dilute the stickiness of any materials. The significance is that it will use waste products from fruit processing (the fibres from skins) to overcome this problem, and it will also be possible to dry sticky materials using material from the fruit itself, rather than additives such as maltodextrin.Read moreRead less
Enhancing biopharmaceuticals: A disruptive bioseparation resin technology. This project aims to develop an innovative and disruptive platform technology for designing and manufacturing tailor-made high-performance bioseparation resins to enhance biopharmaceuticals manufacturing. Bacterial cell factories will be developed to enable biotechnological production of innovative polyester bead-based bioseparation resins, which will revolutionise manufacturing of biopharmaceuticals. Expected outcomes o ....Enhancing biopharmaceuticals: A disruptive bioseparation resin technology. This project aims to develop an innovative and disruptive platform technology for designing and manufacturing tailor-made high-performance bioseparation resins to enhance biopharmaceuticals manufacturing. Bacterial cell factories will be developed to enable biotechnological production of innovative polyester bead-based bioseparation resins, which will revolutionise manufacturing of biopharmaceuticals. Expected outcomes of this project are cost-effective and strongly enhanced approaches for biopharmaceuticals recovery, thereby providing significant benefits to accelerate research and development in early stage discovery and manufacture of biologics, therapeutic proteins and vaccines.Read moreRead less
Fundamentals and applications of continuous-flow microprocessing systems based on supercritical fluids and gas expanded liquids. Microchemical systems have considerable potential in the area of chemical discovery and development. Practical application of these systems requires fundamental understanding and strategies for conversion to appropriate scale. The aim of this project is to overcome such challenges in the development of microstructured continuous-flow technology.
Oral Insulin Delivery facilitated by Enteric Coating using Dense Gas Technologies. Insulin dependant diabetes is a rapidly growing disease. The current method for insulin delivery to the patient is by injection, which is inconvenient. Oral delivery of insulin is a more acceptable method. It is proposed to develop a dense gas technique to coat insulin with a pH sensitive polymer to protect it from the acidic environment of the stomach. Insulin can then be released at the high pH of the intestin ....Oral Insulin Delivery facilitated by Enteric Coating using Dense Gas Technologies. Insulin dependant diabetes is a rapidly growing disease. The current method for insulin delivery to the patient is by injection, which is inconvenient. Oral delivery of insulin is a more acceptable method. It is proposed to develop a dense gas technique to coat insulin with a pH sensitive polymer to protect it from the acidic environment of the stomach. Insulin can then be released at the high pH of the intestine when the polymer is dissolved. Particle size control is feasible by dense gas processes by manipulating operating parameters. Advantages include low residual solvent and manufacture at ambient temperatures.Read moreRead less